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The goal of clinical laboratories is to produce accurate information for clinical decision making in medicine. More than half of the medical decisions made depend on clinical laboratory tests. Patient safety represents an important and critical problem for laboratories. They need to assure that the information they deliver to physicians is accurate, and therefore safe for clinicians to use. Endogenous compounds can interfere with laboratory tests, decreasing accuracy and threatening patient safety. Elevated bilirubin (bilirubinemia) and elevated lipids (lipemia) are common conditions that cause significant interferences with laboratory results. Clinicians depend on laboratories to detect these endogenous interferences. Laboratories must have a means to detect these endogenous interferences, make decisions about reporting results, and evaluate their impact. Most clinical pathology books provide only an abbreviated introduction to the subject, or provide a long list of references, without the necessary foundation for evaluating their significance. Package inserts typically provide scant information. This book provides the empirical and theoretical foundation for these interferences, describes the clinical settings where they occur, and explains their evaluation and detection, allowing the laboratory to interpret the available data on interferences and make the appropriate decision to effectively report test results while protecting patient safety.

Bilirubin -- Isolation and purification. --- Clinical chemistry tests -- Methods. --- Lipids -- Isolation and purification. --- Patient safety. --- Laboratory Techniques and Procedures --- Epidemiologic Research Design --- Bile Pigments --- Investigative Techniques --- Chemicals and Drugs --- Diagnosis --- Pigments, Biological --- Tetrapyrroles --- Epidemiologic Methods --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Heterocyclic Compounds with 4 or More Rings --- Macrocyclic Compounds --- Biological Factors --- Pyrroles --- Heterocyclic Compounds --- Azoles --- Polycyclic Compounds --- Heterocyclic Compounds, 1-Ring --- Bilirubin --- Methods --- Lipids --- Specimen Handling --- Clinical Chemistry Tests --- Reproducibility of Results --- Medicine --- Health & Biological Sciences --- Pathology --- Face Validity --- Reliability (Epidemiology) --- Reliability of Results --- Reproducibility of Findings --- Test-Retest Reliability --- Validity (Epidemiology) --- Reliability and Validity --- Reliability of Result --- Reproducibility Of Result --- Reproducibility of Finding --- Validity of Result --- Validity of Results --- Finding Reproducibilities --- Finding Reproducibility --- Of Result, Reproducibility --- Of Results, Reproducibility --- Reliabilities, Test-Retest --- Reliability, Test-Retest --- Result Reliabilities --- Result Reliability --- Result Validities --- Result Validity --- Result, Reproducibility Of --- Results, Reproducibility Of --- Test Retest Reliability --- Validity and Reliability --- Validity, Face --- Chemistry Test, Clinical --- Clinical Chemistry Test --- Test, Clinical Chemistry --- Tests, Clinical Chemistry --- Chemistry Tests, Clinical --- Chemistry, Clinical --- Specimen Collection --- Collection, Specimen --- Collections, Specimen --- Handling, Specimen --- Handlings, Specimen --- Specimen Collections --- Specimen Handlings --- Lipid --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Bilirubin IX alpha --- Bilirubin, (15E)-Isomer --- Bilirubin, (4E)-Isomer --- Bilirubin, (4E,15E)-Isomer --- Bilirubin, Calcium Salt --- Bilirubin, Disodium Salt --- Bilirubin, Monosodium Salt --- Calcium Bilirubinate --- Hematoidin --- delta-Bilirubin --- Bilirubinate, Calcium --- Calcium Salt Bilirubin --- Disodium Salt Bilirubin --- Monosodium Salt Bilirubin --- Salt Bilirubin, Calcium --- delta Bilirubin --- Heterocyclic Cpds, 1-Ring --- 1-Ring Heterocyclic Compounds --- 1-Ring Heterocyclic Cpds --- Heterocyclic Compounds, 1 Ring --- Heterocyclic Cpds, 1 Ring --- Compounds, Polycyclic --- Hydrocarbons, Cyclic --- Azole --- Heterocyclic Compound --- Compound, Heterocyclic --- Compounds, Heterocyclic --- Pyrrole --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biologic Agent --- Biological Agent --- Biological Agents --- Agent, Biologic --- Agent, Biological --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Biological Products --- Macrocycle Compounds --- Spherands --- Torands --- Compounds, Macrocycle --- Compounds, Macrocyclic --- Bridged-Ring Compounds --- Five Ring Heterocyclic Compounds --- Four Ring Heterocyclic Compounds --- Fused Heterocyclic Compounds, Five-Ring --- Fused Heterocyclic Compounds, Four-Ring --- Heterocyclic Compounds with Four or More Rings --- Heterocyclic Compounds, 4-Ring --- Heterocyclic Compounds, 5-Ring --- Heterocyclic Cpds, 4 Ring --- Heterocyclic Cpds, 4 or More Rings --- Heterocyclic Cpds, 5 Ring --- 4-Ring Heterocyclic Compounds --- 5-Ring Heterocyclic Compounds --- Fused Heterocyclic Compounds, Five Ring --- Fused Heterocyclic Compounds, Four Ring --- Heterocyclic Compounds, 4 Ring --- Heterocyclic Compounds, 5 Ring --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Diagnose --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Disease --- Epidemiologic Method --- Epidemiological Methods --- Methods, Epidemiologic --- Epidemiological Method --- Method, Epidemiologic --- Method, Epidemiological --- Methods, Epidemiological --- Epidemiology --- Tetrapyrrole --- Biological Pigments --- Coloring Agents --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Bile Pigment --- Bilin --- Pigment, Bile --- Pigments, Bile --- Design, Epidemiologic Research --- Designs, Epidemiologic Research --- Epidemiologic Research Designs --- Epidemiological Research Design --- Research Design, Epidemiologic --- Research Designs, Epidemiologic --- Design, Epidemiological Research --- Designs, Epidemiological Research --- Epidemiological Research Designs --- Research Design, Epidemiological --- Research Designs, Epidemiological --- diagnosis --- methods --- Specimen Handling. --- Reproducibility of Results. --- Patient Safety. --- methods. --- isolation & purification. --- isolation & pruification. --- Patient Safeties --- Safeties, Patient --- Safety, Patient --- Risk Management --- Bilirubinemia. --- Clinical Pathology. --- Interference. --- Lipemia.