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Lasers --- Nevus --- Skin Diseases --- Skin --- Therapeutic use --- Atlases. --- Therapy --- Atlases. --- Therapy --- Atlases. --- Laser surgery --- Atlases.

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Melanocytes --- Melanoma --- Melanoma --- Nevus --- Skin Neoplasms --- pathology. --- Pathophysiology. --- pathology. --- pathology. --- pathology.

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Cell Movement --- Integrins --- Melanocytes --- Cell Adhesion --- Dysplastic Nevus Syndrome --- physiology --- physiology --- physiology --- pathology

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This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has deepened our understanding of hereditary mosaics, especially of multiple benign skin tumors. Moreover, recognition of the fundamental difference between the simple segmental and the superimposed types of mosaicism is important for the purpose of genetic counseling. In the third part, the various mosaic skin disorders are examined in depth, including nevi, didymotic disorders, other binary genodermatoses, mosaic manifestations of autosomal skin disorders, and nevoid skin disorders such as phenotypes reflecting functional X-chromosome mosaicism or a superimposed mosaic manifestation of common skin diseases with a polygenic background. Reader-friendly and clearly structured, Mosaicism in Human Skin will appeal to both experienced dermatologists and residents in training, as well as to medical geneticists and pediatricians. .

Paediatrics --- Human genetics --- Pathological dermatology --- Neuropathology --- Ophthalmology --- medische genetica --- hersenen --- dermatologie --- pediatrie --- oftalmologie --- Skin --- Mosaicism. --- Skin Neoplasms. --- Skin Diseases. --- Nevus. --- Diseases.

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Paul Gerson Unna’s “Abtropfung” theory that nevi develop through migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration based on newly acquired observations from histopathology and studies of embryogenesis. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of the aforementioned theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.

Medicine. --- Nevus -- Physiopathology. --- Skin neoplasms -- Physiopathology. --- Mole (Dermatology) --- Skin Diseases --- Neoplasms by Site --- Nevi and Melanomas --- Neoplasms by Histologic Type --- Neoplasms --- Skin and Connective Tissue Diseases --- Diseases --- Skin Neoplasms --- Nevus --- Medicine --- Health & Biological Sciences --- Dermatology --- Skin --- Melanoma. --- Diseases. --- Moles (Dermatology) --- Naevus --- Malignant melanoma --- Melanocytic tumor --- Cutaneous diseases --- Dermatoses --- Dermatology. --- Oncology. --- Medicine & Public Health. --- Cancer --- Neuroendocrine tumors --- Oncology  . --- Tumors