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Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to provide a greater understanding of the relevance of animal models of neuropsychiatric disorders and their role as translational tools for the discovery of CNS drugs being developed for the treatment of these disorders. The focus of this three-volume series of essays is to present a consensual picture of the translational value of animal models from leading experts actively involved in the use of animal models for

Animal models in research. --- Central Nervous System -- drug therapy. --- Disease Models, Animal. --- Drug Discovery. --- Mental Disorders -- drug therapy. --- Neuropharmacology -- methods. --- Neuropharmacology -- Research. --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Neuropharmacology --- Research.

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La question de la prescription excessive de médicaments psychiatriques en France comme en Belgique revient de plus en plus fréquemment sur la place publique. Dans ce contexte, cet ouvrage apporte une information sur chaque classe de médicaments à la fois très complète et indépendante de celle fournie par les firmes pharmaceutiques.Il replace la psychopharmacologie dans sa dimension historique, fait le point sur la réalité des connaissances actuelles en matière de psychotropes : leurs effets réels et leurs risques potentiels dans la pratique clinique. Certaines alternatives aux traitements médicamenteux sont également abordées. Adapté au lectorat francophone par une mise en concordance de la dénomination commune internationale des médicaments avec les noms de marques vendus en France, en Suisse, en Belgique et au Canada, cette traduction tient également compte des différences de pratique entre les mondes francophone et anglo-saxon. Il est destiné à la fois aux prescripteurs et aux professionnels qui travaillent avec les personnes prenant des médicaments psychiatriques.

Mental Disorders --- drug therapy --- Psychotropic Drugs --- Handbooks --- therapeutic use --- QV 77.2 Psychotropic drugs (General or not elsewhere classified) --- adverse effects --- Sleep Initiation and Maintenance Disorders --- Sexual Dysfunctions, Psychological --- Substance-Related Disorders --- Substance Withdrawal Syndrome --- Informed Consent --- Liability, Legal --- Drug Industry --- Psychopharmacology --- Mental Disorders - drug therapy

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Quatrième de couverture : "Cet ouvrage fournit un panorama exhaustif des médicaments du système nerveux qui décrit leurs effets pharmacologiques fondamentaux et cliniques pour justifier leur balance bénéfice/risque dans les principales maladies neurologiques et mentales. Après une introduction sur l'approche globale de modulation pharmacologique du système nerveux central l'ouvrage se décline en trois grandes parties : I. La pharmacologie des systèmes de neurotransmission. II. La pharmacologie des grandes fonctions cérébrales. III. La pharmacologie des principales classes médicamenteuses. Sous la forme de chapitres très illustrés l'ouvrage décrit : les principaux systèmes de neurotransmission et principalesfonctions cérébrales : fonctionnement ; rôles physiologiques et physiopathologiques ; modulation pharmacologiqueles classes pharmacologiques en détaillant selon les cas les pointssuivants : de la physiopathologie aux cibles pharmacologiques ; des cibles aux médicaments ; des médicaments à la pharmacodynamie clinique ; les indications ; la variabilité de la réponse ; le risque médicamenteux; le bon usage. Cet ouvrage offre au lecteur une vision claire et pratique grâce à la mise en exergue des principaux points à retenir et apporte les connaissances indispensables à l'utilisation des médicaments du système nerveux central selon le contexte physiopathologique du patient."

Neuropharmacology --- Neurotic Disorders --- Mental Disorders --- Central Nervous System Agents --- Agents du système nerveux central. --- Maladies du système nerveux --- Troubles mentaux --- Neuropharmacologie. --- Neuropsychopharmacologie. --- Médicaments du système nerveux. --- drug therapy --- traitement médicamenteux. --- Neurotic Disorders - drug therapy --- Mental Disorders - drug therapy --- Neuropharmacology. --- drug therapy. --- Neuropsychopharmacology

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Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the treatment of psychiatric disorders. This “Milestones in Drug Therapy” volume offers a unique, contemporary overview of preclinical and clinical evidence that modulating glutamatergic tone is an effective means of treating psychiatric disorders ranging from depression and anxiety to schizophrenia and drug abuse. The ability to treat diseases such as depression and schizophrenia through multiple, glutamate-based mechanisms offers a unique therapeutic opportunity, as described in this book.

Glutamic Acid -- Therapeutic use. --- Mental Disorders -- Drug therapy. --- Mental illness -- Chemotherapy. --- Mental illness -- Treatment. --- Psychopharmacology --- Glutamic acid --- Neuropsychiatry --- Glutamic Acid --- Excitatory Amino Acid Agents --- Psychiatry and Psychology --- Therapeutics --- Neurotransmitter Agents --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Amino Acids, Acidic --- Amino Acids, Dicarboxylic --- Drug Therapy --- Excitatory Amino Acid Antagonists --- Glutamates --- Mental Disorders --- Amino Acids --- Molecular Mechanisms of Pharmacological Action --- Physiological Effects of Drugs --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Chemical Actions and Uses --- Health & Biological Sciences --- Psychiatry --- Pharmacy, Therapeutics, & Pharmacology --- Psychopharmacotherapy --- Glutamic acid. --- Neuropsychiatry. --- Behavioral neurology --- Glutamate --- Medicine. --- Neurosciences. --- Pharmacology. --- Psychiatry. --- Psychopharmacology. --- Medicine & Public Health. --- Pharmacology/Toxicology. --- Biological psychiatry --- Neurology --- Excitatory amino acids --- Umami (Taste) --- Toxicology. --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Chemicals --- Medicine --- Poisoning --- Poisons --- Psychotropic effects --- Toxicology --- Drug effects --- Medical pharmacology --- Pharmacy --- Physiological effect

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Continuous rigorous research in basic neurosciences and in clinical studies has enormously increased our knowledge of the neurobiological basis of mental functions and of the neuronal dysfunctions underlying such diseases as schizophrenia, depression, attention deficit disorder, and Parkinson's disease. A transmitter system does not work in isolation, it interacts with other transmitters and the balance between several transmitter determines the outcome, either physiological or pathological. Such a critical balance exists between dopamine and glutamate, which in many brain areas play functionally opposing roles. In Dopamine and Glutamate in Psychiatric Disorders, a panel of neurochemists, pharmacologists, experimental psychologists, and clinicians summarizes our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and from that develops novel therapeutic strategies and possibilities for the future. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, on the origin, progression, and cognitive aspects of Parkinson's disease. Additional chapters offer illuminating insights into a variety of psychiatric diseases, including attention deficit hyperactivity disorder, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques. The authors also offer a critical selection and evaluation of relevant literature and a description of future directions for new therapy development. Path-breaking and insightful, Dopamine and Glutamate in Psychiatric Disorders offers behavioral pharmacologists, neurobiologists, and clinicians an enlightening review of the neurobiological basis and treatment strategies of today's most important psychiatric and neurological diseases.

Medicine & Public Health. --- Psychiatry. --- Medicine. --- Médecine --- Psychiatrie --- Antidepressive Agents -- pharmacology. --- Antipsychotic Agents -- pharmacology. --- Dopamine -- Pathophysiology. --- Glutamate -- Pathophysiology. --- Mental Disorders -- drug therapy. --- Mental Disorders -- etiology. --- Nervous System Diseases -- drug therapy. --- Nervous System Diseases -- etiology. --- Neuropsychiatry. --- Neurotransmitter receptors. --- Neuropsychiatry --- Dopamine --- Glutamate --- Neurotransmitter receptors --- Tranquilizing Agents --- Receptors, Catecholamine --- Amino Acids, Dicarboxylic --- Psychiatry and Psychology --- Psychotropic Drugs --- Excitatory Amino Acids --- Receptors, Amino Acid --- Diseases --- Amino Acids, Acidic --- Catecholamines --- Central Nervous System Agents --- Amino Acids --- Receptors, Biogenic Amine --- Central Nervous System Depressants --- Biogenic Monoamines --- Receptors, Neurotransmitter --- Receptors, G-Protein-Coupled --- Amines --- Amino Acids, Peptides, and Proteins --- Receptors, Cell Surface --- Biogenic Amines --- Organic Chemicals --- Physiological Effects of Drugs --- Therapeutic Uses --- Pharmacologic Actions --- Membrane Proteins --- Chemicals and Drugs --- Proteins --- Chemical Actions and Uses --- Antidepressive Agents --- Antipsychotic Agents --- Mental Disorders --- Glutamic Acid --- Receptors, Dopamine --- Receptors, Glutamate --- Nervous System Diseases --- Medicine --- Psychiatry --- Health & Biological Sciences --- Neurology --- Psychiatry - General --- Pathophysiology --- Glutamic acid --- Pathophysiology. --- Behavioral neurology --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Excitatory amino acids --- Umami (Taste) --- Biogenic amines --- Bromocriptine --- Neurotransmitters --- Biological psychiatry --- Cell receptors --- Hormone receptors --- Neural receptors