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Over the years there has been growing interest among the scientific community in investigating sleep and how it affects the memory and other brain functions. It is now well established that sleep helps in memory consolidation and induction of neural plasticity, and that short-term deprivation of either total sleep or rapid eye movement sleep alone can induce memory deficits very quickly. Quantitative and qualitative changes in sleep architecture after different training tasks further suggest that discrete memory types may require specific sleep stage/s for optimal memory consolidation, and studies indicate that sleep deprivation alters synaptic plasticity and membrane excitability in the hippocampal neurons and synaptic up-scaling in the cortical neurons. Further, sleep alteration during pregnancy may increase the risk of depression and adversely affect maternal-child relationships, parenting practices, family functioning, and children's development and general wellbeing. This book coherently discusses all these aspects, with a particular focus on the possible role of sleep in memory consolidation and synaptic plasticity. It also highlights the detrimental effects of sleep loss on mental health, the immune system and cognition. This book is a valuable reference resource for students and researchers working in the area of sleep, memory, or neuronal plasticity.

Human physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Neurobiology. --- Cell membranes . --- Cell physiology. --- Neuropsychology. --- Human Physiology. --- Membrane Biology. --- Cell Physiology. --- Neurophysiology --- Psychophysiology --- Cell function --- Cytology --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Neurosciences

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The study of the extracellular matrix has significantly expanded over the past decade. Although thoroughly researched, the complexity and the dynamic nature of the matrix are still under extensive investigation, yielding a growing number of methods of analysis. In Extracellular Matrix Protocols: Second Edition, expert researchers explore this developing field and provide a number of techniques which can be reproduced in most cell biology labs. This edition contains methods that represent cutting edge unique technologies which are well worth exposure to the broad field and may encourage collaboration with expert labs. Chapters include information on molecular biology techniques to study gene expression, biophysical and biochemical methods for the analysis of structure and composition, and cell biology methods for assessment of cell behavior, matrix assembly and tissue engineering applications. Composed in the highly successful Methods in Molecular Biology(tm) series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Extracellular Matrix Protocols: Second Edition investigates the diverse roles of the extracellular matrix, providing important tools for all researchers in the ECM community.

Human anatomy. --- Cytology. --- Cell membranes. --- Anatomy. --- Cell Biology. --- Membrane Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Anatomy, Human --- Anatomy --- Human biology --- Medical sciences --- Human body

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Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.

Human physiology. --- Toxicology. --- Cell membranes. --- Human Physiology. --- Pharmacology/Toxicology. --- Membrane Biology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Human biology --- Medical sciences --- Physiology --- Human body --- Toxicology

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With nearly one hundred years of intensive study, lipids have proven to be a vital and ever-more-promising area of cell biological research. In Liposomes: Methods and Protocols, leading experts in the related fields explore cutting-edge experimental methods involving all aspects of lipids as essential components of the cell membrane. Volume 2: Biological Membrane Models focuses on detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies. As a volume in the highly successful Methods in Molecular Biology™ series, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Liposomes: Methods and Protocols promises to be an essential source of practical know-how for every investigator, young and seasoned alike, whose research area involves in one way or another phospholipids, glycolipids, or cholesterol.

Toxicology. --- Cytology. --- Cell membranes. --- Lipids. --- Pharmacology/Toxicology. --- Cell Biology. --- Membrane Biology. --- Lipidology. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology

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Membrane proteins, representing nearly 40% of all proteins, are key components of cells involved in many cellular processes, yet only a small number of their structures have been determined. Membrane Protein Structure Determination: Methods and Protocols presents many detailed techniques for membrane protein structure determination used today by bringing together contributions from top experts in the field. Divided into five convenient sections, the book covers various strategies to purify membrane proteins, approaches to get three dimensional crystals and solve the structure by x-ray diffraction, possibilities to gain structural information for a membrane protein using electron microscopy observations, recent advances in nuclear magnetic resonance (NMR), and molecular modelling strategies that can be used either to get membrane protein structures or to move from atomic structure to a dynamic understanding of a molecular functioning mechanism. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Membrane Protein Structure Determination: Methods and Protocols serves as an ideal reference for scientists seeking to further our knowledge of these vital and versatile proteins as well as our overall understanding of the complicated world of cell biology.

Biochemistry. --- Cell membranes. --- Protein Science. --- Membrane Biology. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition