Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.

Technology: general issues --- Biotechnology --- biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.

Technology: general issues --- Biotechnology --- biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment.

cytotoxic activity --- NCI-60 cancer cell line --- pristimerin --- Salacia crassifolia --- Celastraceae --- Brazilian Cerrado biome --- Salacia elliptica --- Cheiloclinium cognatum --- Plenckia populnea --- Aspergillus fumigatus --- Cordyceps sinensis --- isochromanes --- chiral resolution --- ECD calculation --- cytotoxicity --- coronarin D --- JNK --- osteosarcoma --- Zeylenone --- gastric cancer --- invasion --- migration --- apoptosis --- anti-cancer agents --- anthraquinones --- glycosyltransferase --- Dendrobium officinale --- structure elucidation --- anti-tumor activity --- plantation mode --- AR --- Ganoderma tsugae --- lipogenesis --- prostate cancer --- SREBP-1 --- ursolic acid --- betulinic acid --- triterpenoids --- necrotic --- quercetin --- quercetagetin --- patuletin --- lichen --- secondary metabolites --- tumidulin --- stemness potential --- colorectal cancer cells --- oncogene --- transcriptional regulation --- neferine --- FAK/S6K1 --- autophagy --- human neuroblastoma cells --- natural yellow Monascus pigments --- water-soluble --- antioxidation --- MCF-7 cells --- phloretin --- cell proliferation --- inflammation --- glucose uptake --- Catalpa speciosa --- Taxus cuspidata --- Magnolia acuminata --- phenols --- antioxidants --- anticancer --- Colocasia esculenta --- food bioactive --- tarin --- stable nanocapsules --- entrapment efficiency --- no-toxicity --- preclinical tests --- antitumoral activity --- chemotherapeutic adjuvant --- grape leaves --- ASE --- TP --- Antioxidant activities --- Antiproliferative --- pro-apoptotic effects --- Gene expression --- Nutraceuticals --- Cucurbitacin B --- gefitinib-resistant NSCLC --- EGFR --- lysosomal degradation --- CIP2A --- zerumbone --- cancer --- NF-κB --- IL-6/JAK2/STAT3 --- Akt --- FOXO1 --- multiple myeloma --- quality control --- naringenin --- flavonoids --- traditional preparation --- cancer stem cells --- phytochemicals --- plant-derived foods --- fruit --- vegetable --- cell signaling --- Artemisia absinthium --- endoplasmic reticulum stress --- mitochondrial-dependent pathway --- melanoma --- bee venom --- melittin --- temozolomide --- AKT --- MAPK --- antrodin C --- mTOR --- metabolic stability --- capsazepine --- inflammatory diseases --- ROS --- TRPV1 --- PI3K/AKT/mTOR --- CLE-10 --- LC3 --- MDA-MB-231 --- lactoferrin hydrolysate --- copper --- manganese --- gastric cancer cells --- anti-cancer activity --- molecular mechanism --- natural product alkaloids --- cephalotaxine --- protein synthesis inhibition --- antiproliferation agents --- folk medicine --- DLD-1 cells --- doxorubicin --- chemotherapy --- drug resistance --- CrataBL --- glioblastoma --- mesenchymal stem cells --- microenvironment --- plant lectin --- protease inhibitor --- cryptolepine --- neocryptolepine --- isocryptolepine --- antiproliferative activity --- structure activity relationships --- Licochalcone A --- ATM-Chk2 --- 13-ethylberberine --- mitochondrial ROS --- RT-R breast cancer cells --- diallyl disulfide --- PI3K/Akt/mTOR pathway --- Pulsatilla saponin D --- SB365 --- glioblastoma multiforme --- autophagic flux inhibition --- lysosomal membrane permeabilization --- mitochondrial membrane potential --- CLEFMA --- p38 --- proanthocyanins --- TNF-α --- lung adenocarcinoma --- natural compounds --- cervical cancer --- cell cycle arrest --- dicentrine --- metastasis --- glioma --- semi-synthetic derivative --- ingenol --- Euphorbia tirucalli --- protein kinase C --- seaweed --- porphyran --- carrageenan --- anti-cancer --- natural products --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment.

cytotoxic activity --- NCI-60 cancer cell line --- pristimerin --- Salacia crassifolia --- Celastraceae --- Brazilian Cerrado biome --- Salacia elliptica --- Cheiloclinium cognatum --- Plenckia populnea --- Aspergillus fumigatus --- Cordyceps sinensis --- isochromanes --- chiral resolution --- ECD calculation --- cytotoxicity --- coronarin D --- JNK --- osteosarcoma --- Zeylenone --- gastric cancer --- invasion --- migration --- apoptosis --- anti-cancer agents --- anthraquinones --- glycosyltransferase --- Dendrobium officinale --- structure elucidation --- anti-tumor activity --- plantation mode --- AR --- Ganoderma tsugae --- lipogenesis --- prostate cancer --- SREBP-1 --- ursolic acid --- betulinic acid --- triterpenoids --- necrotic --- quercetin --- quercetagetin --- patuletin --- lichen --- secondary metabolites --- tumidulin --- stemness potential --- colorectal cancer cells --- oncogene --- transcriptional regulation --- neferine --- FAK/S6K1 --- autophagy --- human neuroblastoma cells --- natural yellow Monascus pigments --- water-soluble --- antioxidation --- MCF-7 cells --- phloretin --- cell proliferation --- inflammation --- glucose uptake --- Catalpa speciosa --- Taxus cuspidata --- Magnolia acuminata --- phenols --- antioxidants --- anticancer --- Colocasia esculenta --- food bioactive --- tarin --- stable nanocapsules --- entrapment efficiency --- no-toxicity --- preclinical tests --- antitumoral activity --- chemotherapeutic adjuvant --- grape leaves --- ASE --- TP --- Antioxidant activities --- Antiproliferative --- pro-apoptotic effects --- Gene expression --- Nutraceuticals --- Cucurbitacin B --- gefitinib-resistant NSCLC --- EGFR --- lysosomal degradation --- CIP2A --- zerumbone --- cancer --- NF-κB --- IL-6/JAK2/STAT3 --- Akt --- FOXO1 --- multiple myeloma --- quality control --- naringenin --- flavonoids --- traditional preparation --- cancer stem cells --- phytochemicals --- plant-derived foods --- fruit --- vegetable --- cell signaling --- Artemisia absinthium --- endoplasmic reticulum stress --- mitochondrial-dependent pathway --- melanoma --- bee venom --- melittin --- temozolomide --- AKT --- MAPK --- antrodin C --- mTOR --- metabolic stability --- capsazepine --- inflammatory diseases --- ROS --- TRPV1 --- PI3K/AKT/mTOR --- CLE-10 --- LC3 --- MDA-MB-231 --- lactoferrin hydrolysate --- copper --- manganese --- gastric cancer cells --- anti-cancer activity --- molecular mechanism --- natural product alkaloids --- cephalotaxine --- protein synthesis inhibition --- antiproliferation agents --- folk medicine --- DLD-1 cells --- doxorubicin --- chemotherapy --- drug resistance --- CrataBL --- glioblastoma --- mesenchymal stem cells --- microenvironment --- plant lectin --- protease inhibitor --- cryptolepine --- neocryptolepine --- isocryptolepine --- antiproliferative activity --- structure activity relationships --- Licochalcone A --- ATM-Chk2 --- 13-ethylberberine --- mitochondrial ROS --- RT-R breast cancer cells --- diallyl disulfide --- PI3K/Akt/mTOR pathway --- Pulsatilla saponin D --- SB365 --- glioblastoma multiforme --- autophagic flux inhibition --- lysosomal membrane permeabilization --- mitochondrial membrane potential --- CLEFMA --- p38 --- proanthocyanins --- TNF-α --- lung adenocarcinoma --- natural compounds --- cervical cancer --- cell cycle arrest --- dicentrine --- metastasis --- glioma --- semi-synthetic derivative --- ingenol --- Euphorbia tirucalli --- protein kinase C --- seaweed --- porphyran --- carrageenan --- anti-cancer --- natural products --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment.

Research & information: general --- Biology, life sciences --- cytotoxic activity --- NCI-60 cancer cell line --- pristimerin --- Salacia crassifolia --- Celastraceae --- Brazilian Cerrado biome --- Salacia elliptica --- Cheiloclinium cognatum --- Plenckia populnea --- Aspergillus fumigatus --- Cordyceps sinensis --- isochromanes --- chiral resolution --- ECD calculation --- cytotoxicity --- coronarin D --- JNK --- osteosarcoma --- Zeylenone --- gastric cancer --- invasion --- migration --- apoptosis --- anti-cancer agents --- anthraquinones --- glycosyltransferase --- Dendrobium officinale --- structure elucidation --- anti-tumor activity --- plantation mode --- AR --- Ganoderma tsugae --- lipogenesis --- prostate cancer --- SREBP-1 --- ursolic acid --- betulinic acid --- triterpenoids --- necrotic --- quercetin --- quercetagetin --- patuletin --- lichen --- secondary metabolites --- tumidulin --- stemness potential --- colorectal cancer cells --- oncogene --- transcriptional regulation --- neferine --- FAK/S6K1 --- autophagy --- human neuroblastoma cells --- natural yellow Monascus pigments --- water-soluble --- antioxidation --- MCF-7 cells --- phloretin --- cell proliferation --- inflammation --- glucose uptake --- Catalpa speciosa --- Taxus cuspidata --- Magnolia acuminata --- phenols --- antioxidants --- anticancer --- Colocasia esculenta --- food bioactive --- tarin --- stable nanocapsules --- entrapment efficiency --- no-toxicity --- preclinical tests --- antitumoral activity --- chemotherapeutic adjuvant --- grape leaves --- ASE --- TP --- Antioxidant activities --- Antiproliferative --- pro-apoptotic effects --- Gene expression --- Nutraceuticals --- Cucurbitacin B --- gefitinib-resistant NSCLC --- EGFR --- lysosomal degradation --- CIP2A --- zerumbone --- cancer --- NF-κB --- IL-6/JAK2/STAT3 --- Akt --- FOXO1 --- multiple myeloma --- quality control --- naringenin --- flavonoids --- traditional preparation --- cancer stem cells --- phytochemicals --- plant-derived foods --- fruit --- vegetable --- cell signaling --- Artemisia absinthium --- endoplasmic reticulum stress --- mitochondrial-dependent pathway --- melanoma --- bee venom --- melittin --- temozolomide --- AKT --- MAPK --- antrodin C --- mTOR --- metabolic stability --- capsazepine --- inflammatory diseases --- ROS --- TRPV1 --- PI3K/AKT/mTOR --- CLE-10 --- LC3 --- MDA-MB-231 --- lactoferrin hydrolysate --- copper --- manganese --- gastric cancer cells --- anti-cancer activity --- molecular mechanism --- natural product alkaloids --- cephalotaxine --- protein synthesis inhibition --- antiproliferation agents --- folk medicine --- DLD-1 cells --- doxorubicin --- chemotherapy --- drug resistance --- CrataBL --- glioblastoma --- mesenchymal stem cells --- microenvironment --- plant lectin --- protease inhibitor --- cryptolepine --- neocryptolepine --- isocryptolepine --- antiproliferative activity --- structure activity relationships --- Licochalcone A --- ATM-Chk2 --- 13-ethylberberine --- mitochondrial ROS --- RT-R breast cancer cells --- diallyl disulfide --- PI3K/Akt/mTOR pathway --- Pulsatilla saponin D --- SB365 --- glioblastoma multiforme --- autophagic flux inhibition --- lysosomal membrane permeabilization --- mitochondrial membrane potential --- CLEFMA --- p38 --- proanthocyanins --- TNF-α --- lung adenocarcinoma --- natural compounds --- cervical cancer --- cell cycle arrest --- dicentrine --- metastasis --- glioma --- semi-synthetic derivative --- ingenol --- Euphorbia tirucalli --- protein kinase C --- seaweed --- porphyran --- carrageenan --- anti-cancer --- natural products --- n/a