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Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms. Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Infertility, Male --- Spermatogenesis --- Genetic aspects --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Formation --- Diseases

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Taxonomie --- taxonomy --- Genitalia --- Fécondation --- Fertilization --- Parthénogénèse --- Parthenogenesis --- Développement biologique --- biological development --- Métamorphose --- Metamorphosis --- Gamétogénèse --- Gametogenesis --- Entomologie --- Entomology --- Traite --- milking --- Zoologie --- Zoology --- Insectes --- Reproduction. --- Reproduction (biologie)

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Developmental biology. --- Gametogenesis --- Morphogenesis --- Animals --- Embryology --- Growth and Development. --- Fertilization. --- Animaux --- Biologie du développement. --- Fécondation. --- Gamétogenèse. --- Morphogenèse. --- Embryologie. --- Cell recognition. --- Development. --- Développement.

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Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine. Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest. "This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm." Pawan K. Singal St. Boniface General Hospital Research Center .

Spermatogenesis. --- Proteomics. --- Molecular biology --- Proteins --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Formation --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology. --- Proteins. --- Protein Biochemistry. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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Developmental biology --- Embryology --- Biologie du développement --- Embryologie --- Developmental Biology --- Biologie du développement. --- Embryologie. --- Biologie du développement --- Monograph --- Gametogenesis --- Biological development --- Morphogenesis --- Fecundation --- Embryonic development --- Organogenesis --- Animals --- Development --- Cleavage stage, Ovum --- Cell differentiation --- Fertility --- Cells --- Cell recognition --- Interactions --- Genetics