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There is no question that loss of cell cycle checkpoint regulation is an intrinsic characteristic of cancer. However, many tumors retain parallel checkpoint pathways that are activated by antitumor agents and facilitate therapeutic response. Failures in these therapy-linked checkpoint controls are closely associated with cancers that are highly resistant to therapeutic interventions. Checkpoint Controls and Targets in Cancer provides present-day mechanistic understandings of how multiple sets of proteins orchestrate cell cycle progression, discusses critical checkpoint controls that are evaded for cancer development, focuses on checkpoint pathways associated with antitumor effects, and identifies specific checkpoint regulators for targeting with small molecules in the clinical management of cancer. These aspects of cell cycle checkpoints are articulated critically by renowned experts from both academia and industry, and new concepts are forwarded that challenge existing dogmas. Collectively, Checkpoint Controls and Targets in Cancer provides a unique collection of insightful contributions, which are timely and offer significant interest and appeal to basic, translational and clinical scientists.

Antineoplastic agents -- Development. --- Cancer cells -- Growth -- Regulation. --- Cellular control mechanisms. --- Drug Resistance, Neoplasm --- Cell Cycle --- Pharmacology --- Cell Cycle Proteins --- Antineoplastic Agents --- Neoplasms --- Drug Therapy --- Proteins --- Biological Science Disciplines --- Therapeutics --- Cell Physiological Processes --- Diseases --- Therapeutic Uses --- Drug Resistance --- Amino Acids, Peptides, and Proteins --- Pharmacologic Actions --- Pharmacological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Cell Physiological Phenomena --- Physiological Phenomena --- Chemicals and Drugs --- Disciplines and Occupations --- Phenomena and Processes --- Chemical Actions and Uses --- Oncology --- Public Health - General --- Animal Biochemistry --- Human Anatomy & Physiology --- Public Health --- Medicine --- Health & Biological Sciences --- Antineoplastic agents --- Cancer cells --- Development. --- Growth --- Regulation. --- Cell regulation --- Regulation of cancer cell growth --- Medicine. --- Cancer research. --- Pharmacology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Tumors --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Biological control systems --- Cell metabolism --- Cellular control mechanisms

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The cell cycle is tightly regulated on many different levels to ensure properly controlled proliferation. Deregulation of cell cycle regulation is a hallmark of cancer. In this book, many aspects of cell cycle regulation are discussed, which include G1, S, M phase control, ubiquitin-mediated degradation, DNA damage response, mitotic spindle checkpoint, the centrosome cycle, Retinoblastoma protein family, the Myc oncogene, and mouse models for tumor suppressors, cyclin-dependent kinases, and meiosis. These chapters written by experts provide an updated view on how the cell cycle is regulated in vivo and about the involvement of cell cycle regulators in cancer.

Cell Cycle. --- Cell Cycle Proteins --- Cell Proliferation. --- Tumor Suppressor Proteins. --- Cellular control mechanisms. --- Cell cycle --- Régulation cellulaire --- Cycle cellulaire --- physiology. --- Regulation. --- Régulation --- Tumor Suppressor Proteins --- Cell Cycle --- Cell Proliferation --- Neoplasm Proteins --- Cell Physiological Processes --- Proteins --- Cell Growth Processes --- Amino Acids, Peptides, and Proteins --- Growth --- Cell Physiological Phenomena --- Growth and Development --- Chemicals and Drugs --- Phenomena and Processes --- Physiological Processes --- Physiological Phenomena --- Cytology --- Biology --- Health & Biological Sciences --- Development and Growth --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Processes, Cell Growth --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Proteins, Neoplasm --- Cell Division Cycle Proteins --- Cell-Cycle Regulatory Proteins --- cdc Proteins --- Cell Cycle Regulatory Proteins --- Cell Multiplication --- Cell Number Growth --- Cell Growth in Number --- Cellular Proliferation --- Growth, Cell Number --- Multiplication, Cell --- Number Growth, Cell --- Proliferation, Cell --- Proliferation, Cellular --- Cell Division Cycle --- Cell Cycles --- Cell Division Cycles --- Cycle, Cell --- Cycle, Cell Division --- Cycles, Cell --- Cycles, Cell Division --- Division Cycle, Cell --- Division Cycles, Cell --- Growth Suppressor Proteins --- Metastasis Suppressor Proteins --- Proteins, Growth Suppressor --- Proteins, Metastasis Suppressor --- Proteins, Tumor Suppressor --- physiology --- Life sciences. --- Cancer research. --- Biochemistry. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Cancer Research. --- Biochemistry, general. --- Cytology. --- Oncology. --- Tumors --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cytologists --- Composition --- Cancer research