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This Special Issue contains review articles focusing on several lymphoma entities included in the current WHO classification. The aim of the book is to guide the readers in understanding the evolution of lymphoma classification. The clinicopathological entities described in this issue have been analyzed through the molecular mechanisms involved in their pathogenesis.

Medicine --- lymphomas in PLWH --- KSHV/HHV8 --- EBV --- lymphoma classification --- management --- cART --- HLX --- HOXB9 --- NFIB --- PBX1 --- STAT3 --- TLX2 --- autoimmune hemolytic anemia --- cold agglutinin --- B-cell lymphoproliferative disorder --- lymphomagenesis --- methylation --- histone modification --- indolent --- T-cell --- NK-cell --- lymphoproliferative disorder --- gastrointestinal tract --- genetics --- cell of origin --- T follicular helper cells --- TFH lymphoma --- angioimmunoblastic T-cell lymphoma --- follicular T-cell lymphoma --- peripheral T-cell lymphoma of T-follicular helper immunophenotype --- peripheral T-cell lymphoma --- primary cutaneous B-cell lymphoma --- primary cutaneous marginal zone B-cell lymphoma --- primary cutaneous follicle centre lymphoma --- primary cutaneous diffuse large B-cell lymphoma, leg-type --- primary cutaneous diffuse large B-cell lymphoma, not otherwise specified --- intravascular B-cell lymphoma --- EBV+ mucocutaneous ulcer --- Burkitt lymphoma --- epidemiology --- Plasmodium falciparum --- Epstein Barr virus --- registry studies --- multimodal cancer --- non-Hodgkin lymphoma --- HIV/AIDS --- follicular lymphoma --- in situ follicular neoplasia --- FL transformation --- FL in young patients --- diffuse large B-cell lymphoma NOS --- high grade B-cell lymphoma --- lymphoma --- gene expression profiling --- tumor microenvironment --- diagnostics --- centrocytic lymphoma --- intermediate lymphocytic lymphoma --- Jaffe --- mantle cell lymphoma --- mantle zone lymphoma --- cyclin D1 --- lymphomas --- people living with HIV --- tumor prevention in people living with HIV --- KSHV --- BCL2 rearrangement --- genetic alterations --- histological transformation --- targeted therapies --- transformed follicular lymphoma --- lymphoproliferative neoplasms of uncertain biological significance --- monoclonal B-cell lymphocytosis --- “in situ” follicular neoplasia --- “in situ” mantle cell neoplasia --- atypical germinal centers --- large B-cell lymphoma with IRF4 rearrangement --- “in situ” high-grade B lymphomas --- Hodgkin lymphoma

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Antiviral agents are used for the treatment of viral diseases. Antiviral drugs have been successfully developed and used clinically for a limited number of important human viral diseases notably caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), herpes, and influenza viruses. Despite the successes of these antiviral drugs, issues with drug resistance and toxicity remain challenging. These challenges are driving research to identify new drug candidates and to investigate novel drug targets to develop new mechanistic drug classes. Antiviral agents are not available against many viruses that cause human disease and economic burdens; in particular, the development of antiviral agents against emerging, re-emerging, and neglected viruses is increasingly becoming a priority. This book includes six review articles that discuss new antiviral strategies. The reviews either discuss advances relating to a specific virus or new therapeutic targets and approaches. The book includes 15 original research articles reporting new antiviral agents against a variety of clinically and economically important viruses and studies into the prevalence or acquisition of drug resistance. Overall, this book is an exciting collection of new research and ideas relating to the development of antiviral agents.

Research & information: general --- Biology, life sciences --- Zika virus --- nucleoside analogues --- antiviral agents --- NS5 --- prodrugs --- ProTides --- neural stem cells --- RNA-dependent RNA polymerase --- cytomegalovirus --- latent infection --- TALEN --- Surveyor nuclease mutation detection assay --- ie-1 gene --- quantitative real-time PCR --- Epstein-Barr virus --- herpes viruses --- lytic gene expression --- Burkitt lymphoma cells --- clozapine --- antipsychotic drug --- antiviral drug --- enteroviruses --- coxsackievirus B4 --- persistent infection --- fluoxetine --- resistance --- mutations --- herpes B virus --- macacine herpesvirus-1 --- genistein --- flavonoids --- acyclovir --- ganciclovir --- Plantago asiatica --- Clerodendrum trichotomum --- RSV --- therapeutic effects --- acteoside --- human antimicrobial peptides --- antiviral strategies --- defensins --- cathelicidins --- hepcidins --- transferrins --- influenza A virus --- brevilin A --- antiviral --- sesquiterpene lactone --- replication --- PRRSV --- polyethylenimine --- PEI --- virion internalization --- endocytosis --- HIV --- pediatrics --- Ethiopia --- pre-treatment drug resistance --- combination antiretroviral therapy (cART) --- dried plasma spots --- dried blood spots --- sphingolipids --- glycosphingolipids --- viruses --- lipid biosynthesis --- flavivirus --- Japanese encephalitis virus --- furin inhibitor --- precursor membrane protein --- measles virus --- central nervous system --- tropism --- treatments --- porcine reproductive and respiratory syndrome virus --- ginsenoside Rg1 --- antiviral activity --- pro-inflammatory factor --- NF-κB signaling pathway --- acute/latent infection --- congenital infection --- antiviral agent --- therapeutic strategies --- nucleic acid-based therapeutic approach --- HCMV vaccine --- adoptive cell therapy --- Rev response element --- chemical footprinting --- SHAPE --- drug discovery --- branched peptides --- herpesvirus --- immediate-early --- IE1 --- IE2 --- ribozyme --- RNA interference --- CRISPR/Cas --- small molecule --- orthohantavirus --- phenyl-benzotriazoles --- C-FRA --- Porcine circovirus type 2 --- epigallocatechin gallate --- heparan sulfate --- antiviral effect --- virus attachment --- microvirin --- lectin --- human immunodeficiency virus --- hepatitis C virus --- antiviral inhibitor --- non-immunogenic --- viral entry --- protein drugs --- LUMS1 --- oleanane-type derivatives --- influenza A virus (IAV) --- virus entry inhibitors --- hemagglutinin (HA) --- Zika virus --- nucleoside analogues --- antiviral agents --- NS5 --- prodrugs --- ProTides --- neural stem cells --- RNA-dependent RNA polymerase --- cytomegalovirus --- latent infection --- TALEN --- Surveyor nuclease mutation detection assay --- ie-1 gene --- quantitative real-time PCR --- Epstein-Barr virus --- herpes viruses --- lytic gene expression --- Burkitt lymphoma cells --- clozapine --- antipsychotic drug --- antiviral drug --- enteroviruses --- coxsackievirus B4 --- persistent infection --- fluoxetine --- resistance --- mutations --- herpes B virus --- macacine herpesvirus-1 --- genistein --- flavonoids --- acyclovir --- ganciclovir --- Plantago asiatica --- Clerodendrum trichotomum --- RSV --- therapeutic effects --- acteoside --- human antimicrobial peptides --- antiviral strategies --- defensins --- cathelicidins --- hepcidins --- transferrins --- influenza A virus --- brevilin A --- antiviral --- sesquiterpene lactone --- replication --- PRRSV --- polyethylenimine --- PEI --- virion internalization --- endocytosis --- HIV --- pediatrics --- Ethiopia --- pre-treatment drug resistance --- combination antiretroviral therapy (cART) --- dried plasma spots --- dried blood spots --- sphingolipids --- glycosphingolipids --- viruses --- lipid biosynthesis --- flavivirus --- Japanese encephalitis virus --- furin inhibitor --- precursor membrane protein --- measles virus --- central nervous system --- tropism --- treatments --- porcine reproductive and respiratory syndrome virus --- ginsenoside Rg1 --- antiviral activity --- pro-inflammatory factor --- NF-κB signaling pathway --- acute/latent infection --- congenital infection --- antiviral agent --- therapeutic strategies --- nucleic acid-based therapeutic approach --- HCMV vaccine --- adoptive cell therapy --- Rev response element --- chemical footprinting --- SHAPE --- drug discovery --- branched peptides --- herpesvirus --- immediate-early --- IE1 --- IE2 --- ribozyme --- RNA interference --- CRISPR/Cas --- small molecule --- orthohantavirus --- phenyl-benzotriazoles --- C-FRA --- Porcine circovirus type 2 --- epigallocatechin gallate --- heparan sulfate --- antiviral effect --- virus attachment --- microvirin --- lectin --- human immunodeficiency virus --- hepatitis C virus --- antiviral inhibitor --- non-immunogenic --- viral entry --- protein drugs --- LUMS1 --- oleanane-type derivatives --- influenza A virus (IAV) --- virus entry inhibitors --- hemagglutinin (HA)

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Cancer --- Viral carcinogenesis --- Burkitt Lymphoma --- Hepatitis B virus --- Leukemia --- Liver Neoplasms --- Nasopharyngeal Neoplasms --- Penile Neoplasms --- Sarcoma, Kaposi --- Uterine Cervical Neoplasms --- Cancer of Cervix --- Cancer of the Cervix --- Cancer of the Uterine Cervix --- Cervical Cancer --- Cervical Neoplasms --- Cervix Cancer --- Cervix Neoplasms --- Neoplasms, Cervical --- Neoplasms, Cervix --- Uterine Cervical Cancer --- Cancer, Cervix --- Cancer, Uterine Cervical --- Cancers, Cervix --- Cancers, Uterine Cervical --- Cervical Cancer, Uterine --- Cervical Cancers, Uterine --- Cervical Neoplasm --- Cervical Neoplasm, Uterine --- Cervical Neoplasms, Uterine --- Cervix Neoplasm --- Neoplasm, Cervical --- Neoplasm, Cervix --- Neoplasm, Uterine Cervical --- Neoplasms, Uterine Cervical --- Uterine Cervical Cancers --- Uterine Cervical Neoplasm --- Uterine Cervical Dysplasia --- Cervical Intraepithelial Neoplasia --- Kaposi's Sarcoma --- Multiple Idiopathic Pigmented Hemangiosarcoma --- Kaposi Sarcoma --- Kaposis Sarcoma --- Sarcoma, Kaposi's --- Cancer of the Penis --- Neoplasms, Penile --- Neoplasms, Penis --- Penis Cancer --- Penis Neoplasms --- Cancer of Penis --- Penile Cancer --- Cancer, Penile --- Cancer, Penis --- Cancers, Penile --- Cancers, Penis --- Neoplasm, Penile --- Neoplasm, Penis --- Penile Cancers --- Penile Neoplasm --- Penis Cancers --- Penis Neoplasm --- Cancer of the Nasopharynx --- Nasopharynx Cancer --- Nasopharynx Neoplasms --- Neoplasms, Nasopharyngeal --- Cancer of Nasopharynx --- Nasopharyngeal Cancer --- Cancer, Nasopharyngeal --- Cancer, Nasopharynx --- Cancers, Nasopharyngeal --- Cancers, Nasopharynx --- Nasopharyngeal Cancers --- Nasopharyngeal Neoplasm --- Nasopharynx Cancers --- Nasopharynx Neoplasm --- Neoplasm, Nasopharyngeal --- Neoplasm, Nasopharynx --- Neoplasms, Nasopharynx --- Cancer of the Liver --- Cancer, Hepatocellular --- Hepatic Neoplasms --- Hepatocellular Cancer --- Neoplasms, Hepatic --- Neoplasms, Liver --- Cancer of Liver --- Hepatic Cancer --- Liver Cancer --- Cancer, Hepatic --- Cancer, Liver --- Cancers, Hepatic --- Cancers, Hepatocellular --- Cancers, Liver --- Hepatic Cancers --- Hepatic Neoplasm --- Hepatocellular Cancers --- Liver Cancers --- Liver Neoplasm --- Neoplasm, Hepatic --- Neoplasm, Liver --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Hematologic Neoplasms --- Burkitt Leukemia --- Burkitt's Leukemia --- Burkitt's Lymphoma --- Burkitt's Tumor --- Leukemia, Lymphoblastic, Burkitt-Type --- Leukemia, Lymphocytic, L3 --- Lymphocytic Leukemia, L3 --- African Lymphoma --- Burkitt Cell Leukemia --- Burkitt Tumor --- Lymphoma, Burkitt --- Burkitts Leukemia --- Burkitts Lymphoma --- Burkitts Tumor --- L3 Lymphocytic Leukemia --- L3 Lymphocytic Leukemias --- Leukemia, Burkitt --- Leukemia, Burkitt Cell --- Leukemia, Burkitt's --- Leukemia, L3 Lymphocytic --- Lymphoma, African --- Lymphoma, Burkitt's --- Tumor, Burkitt --- Tumor, Burkitt's --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Congresses --- pathogenicity --- Oncology. Neoplasms --- Medical microbiology, virology, parasitology --- Africa --- Cancer, Cervical --- Cervical Cancers