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Bovine leukosis --- viruses. --- viruses --- monoclonal antibodies --- Virus blv

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Les virus HTLV (Human T-cell leukemia virus) et BLV (Bovine leukemia virus) sont des rétrovirus étroitement apparentés du genre Deltarétrovirus. Tous deux sont à l’origine de maladies hématologiques agressives et fatales ayant pour cibles les lymphocytes T (HTLV) et B (BLV). En outre, HTLV est également responsable d’une maladie inflammatoire (HAM/TSP). Ces virus ont pour particularité qu’ils présentent une période de latence au cours de laquelle les individus sont considérés comme porteurs asymptomatiques. Notre hypothèse de travail postule que les transcrits antisens sont impliqués dans la répression de la transcription sens, ce qui constitue une piste quant aux mécanismes associés à l’évasion immunitaire. Les objectifs de ce travail consistent à évaluer (1) l’interaction entre les ARNs rétroviraux antisens et la déméthylase spécifique de la lysine 1 (LSD1) et (2) leur effet sur la transactivation du promoteur viral par la protéine Tax. Les résultats révèlent l’existence d’une interaction entre LSD1 et les ARNs antisens de BLV et HTLV-2, ainsi qu’un effet répresseur de LSD1 et l’ARN antisens de HTLV-1 sur la transactivation du promoteur LTR. Ces recherches sont destinées à mieux comprendre les mécanismes associés à la latence virale. The viruses HTLV (Human T-cell leukemia virus) and BLV (Bovine leukemia virus) are closely related retroviruses classified in the genus Deltaretrovirus. Both are responsible for aggressive and fatal haematological diseases that target T-cells (HTLV) or B-cells (BLV). In addition, HTLV is also responsible for an inflammatory disease (HAM/TSP). Those viruses have the particular feature of having a latency stage during which individuals are considered as asymptomatic carriers. Our working hypothesis postulates that antisense transcripts are involved in the repression of the sense transcription, which constitutes a path of the mechanisms associated to immune escape. The objectives of this study are to evaluate (1) the interaction between the antisense retroviral RNAs and the lysine specific demethylase 1 (LSD1) and (2) their effect on the transactivation of the viral promoter by the viral protein Tax. Results show the existence of an interaction between LSD1 and the BLV/HTLV-2 antisense RNAs and a repressor effect of LSD1 and HTLV-1 antisense RNA on the transactivation of the LTR promoter. This research aims to lead to a better understanding of the mechanisms associated with viral latency.

HTLV --- BLV --- LSD1 --- RNA-immunoprecipitation --- Sciences du vivant > Biochimie, biophysique & biologie moléculaire

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AIDS (Disease) --- Acquired Immunodeficiency Syndrome --- Acquired Immune Deficiency Syndrome --- Acquired Immuno-Deficiency Syndrome --- AIDS --- Immunodeficiency Syndrome, Acquired --- Immunologic Deficiency Syndrome, Acquired --- Acquired Immuno Deficiency Syndrome --- Acquired Immuno-Deficiency Syndromes --- Acquired Immunodeficiency Syndromes --- Immuno-Deficiency Syndrome, Acquired --- Immuno-Deficiency Syndromes, Acquired --- Immunodeficiency Syndromes, Acquired --- Syndrome, Acquired Immuno-Deficiency --- Syndrome, Acquired Immunodeficiency --- Syndromes, Acquired Immuno-Deficiency --- Syndromes, Acquired Immunodeficiency --- Acquired Immunodeficiency Syndrome. --- Deltaretrovirus Infections. --- Deltaretrovirus. --- Retroviridae. --- Leukemogenic Viruses --- Leukoviruses --- Oncornaviruses --- Oncovirinae --- Oncoviruses --- Oncoviruses, Type C --- RNA Tumor Viruses --- Retroviruses --- Type C Oncoviruses --- C Oncovirus, Type --- C Oncoviruses, Type --- Leukemogenic Virus --- Leukovirus --- Oncornavirus --- Oncovirus --- Oncovirus, Type C --- RNA Tumor Virus --- Retrovirus --- Tumor Virus, RNA --- Tumor Viruses, RNA --- Type C Oncovirus --- Virus, Leukemogenic --- Virus, RNA Tumor --- Viruses, Leukemogenic --- Viruses, RNA Tumor --- Human T Cell Leukemia Lymphoma Viruses --- Human T Cell Leukemia Viruses --- Leukemia Viruses, Human T Cell --- T Cell Leukemia Viruses, Human --- BLV-HTLV Viruses --- HTLV Viruses --- HTLV-BLV Viruses --- Human T-Cell Leukemia Viruses --- Human T-Cell Leukemia-Lymphoma Viruses --- Leukemia Viruses, Human T-Cell --- T-Cell Leukemia Viruses, Human --- BLV HTLV Viruses --- HTLV BLV Viruses --- BLV Infections --- HTLV Infections --- HTLV-BLV Infections --- BLV Infection --- Deltaretrovirus Infection --- HTLV BLV Infections --- HTLV Infection --- HTLV-BLV Infection --- Infection, Deltaretrovirus --- Infections, Deltaretrovirus --- CD4-Positive T-Lymphocytes --- HIV-1 --- AIDS Arteritis, Central Nervous System --- Acquired immune deficiency syndrome --- Acquired immunodeficiency syndrome --- Acquired immunological deficiency syndrome --- HIV infections --- Immunological deficiency syndromes --- Virus-induced immunosuppression

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Retroviruses --- Retroviruses. --- Retrovirology. --- Retroviridae --- Retroviridae Infections --- Deltaretrovirus --- HIV --- C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- RNA tumor viruses --- Oncogenic viruses --- RNA viruses --- Acquired Immune Deficiency Syndrome Virus --- Acquired Immunodeficiency Syndrome Virus --- Human Immunodeficiency Virus --- Human T Cell Lymphotropic Virus Type III --- Human T Lymphotropic Virus Type III --- Human T-Cell Leukemia Virus Type III --- Immunodeficiency Virus, Human --- Immunodeficiency Viruses, Human --- Virus, Human Immunodeficiency --- Viruses, Human Immunodeficiency --- AIDS Virus --- HTLV-III --- Human Immunodeficiency Viruses --- Human T-Cell Lymphotropic Virus Type III --- Human T-Lymphotropic Virus Type III --- LAV-HTLV-III --- Lymphadenopathy-Associated Virus --- AIDS Viruses --- Human T Cell Leukemia Virus Type III --- Lymphadenopathy Associated Virus --- Lymphadenopathy-Associated Viruses --- Virus, AIDS --- Virus, Lymphadenopathy-Associated --- Viruses, AIDS --- Viruses, Lymphadenopathy-Associated --- Human Immunodeficiency Virus Proteins --- Human T Cell Leukemia Lymphoma Viruses --- Human T Cell Leukemia Viruses --- Leukemia Viruses, Human T Cell --- T Cell Leukemia Viruses, Human --- BLV-HTLV Viruses --- HTLV Viruses --- HTLV-BLV Viruses --- Human T-Cell Leukemia Viruses --- Human T-Cell Leukemia-Lymphoma Viruses --- Leukemia Viruses, Human T-Cell --- T-Cell Leukemia Viruses, Human --- BLV HTLV Viruses --- HTLV BLV Viruses --- Infections, Retroviridae --- Infections, Retrovirus --- XMRV Infection --- Xenotropic MuLV-related Virus Infection --- Xenotropic Murine Leukemia Virus-related Virus Infection --- Retrovirus Infections --- Infection, Retroviridae --- Infection, Retrovirus --- Infection, XMRV --- Infections, XMRV --- Retroviridae Infection --- Retrovirus Infection --- XMRV Infections --- Xenotropic MuLV related Virus Infection --- Xenotropic Murine Leukemia Virus related Virus Infection --- Leukemogenic Viruses --- Oncovirinae --- Oncoviruses, Type C --- RNA Tumor Viruses --- Type C Oncoviruses --- C Oncovirus, Type --- C Oncoviruses, Type --- Leukemogenic Virus --- Leukovirus --- Oncornavirus --- Oncovirus --- Oncovirus, Type C --- RNA Tumor Virus --- Retrovirus --- Tumor Virus, RNA --- Tumor Viruses, RNA --- Type C Oncovirus --- Virus, Leukemogenic --- Virus, RNA Tumor --- Viruses, Leukemogenic --- Viruses, RNA Tumor --- Agriculture Sciences --- Soil Chemistry, Microbiology, Fertility & Fertilizers