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Medicine --- Vascular Disease --- Aneurysm

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This guideline covers diagnosing and treating an aneurysmal (caused by a ruptured aneurysm) subarachnoid haemorrhage and its complications. It provides recommendations to improve diagnosis and ensure that the most effective treatments are offered. It includes guidance on follow-up care and information for people (aged 16 and over) who have had an aneurysmal subarachnoid haemorrhage, their families and carers.

Intracranial Aneurysm --- therapy.

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This dissertation explores novel treatment strategies for abdominal aortic aneurysm (AAA), a condition characterized by the weakening of the aortic wall due to inflammation and vascular remodeling. The author investigates cellular and molecular pathways involved in AAA, utilizing animal models and human biopsies. Key findings include the role of toll-like receptors in immune response, the protective effects of imatinib and adiponectin, and the contribution of periaortic adipose tissue inflammation. The research aims to develop drug-based therapies for AAA, a disease currently managed primarily through imaging and surgical techniques.

Abdominal aneurysm. --- Inflammation.

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Aortic Aneurysm, Abdominal --- Aortic Aneurysm, Abdominal --- diagnosis. --- radionuclide imaging.

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Aortic aneurysms are relatively common diseases characterized by a focal dilatation of the aorta to a size of 50% or greater than the normal diameter of the vessel. Based upon the location in can be divided in thoracic aorta aneurysms (TAA) and abdominal aortic aneurysms (AAA). Patients with aortic aneurysms generally have no symptoms; it progresses with time, resulting in rupture or dissection of the diseased aorta. These late presentations are associated with a high mortality rate, exceeding 50%. Therefore the therapeutic goal is prevention of rupture or dissection. The strongest predictor for these potentially fatal presentations is the diameter of the aneurysm, which will determine the clinical strategy. Surgical procedures are currently the only established therapeutic option for large aneurysms. The dilated aorta is then replaced with an artificial graft by open surgery or by endovascular repair whereby a coated stent is placed in the aorta through a catheter. In contrast there is no effective therapy for small aneurysms. Graft replacement or endovascular repair do not offer a survival benefit in these cases, and there is no proven medical therapy that stops progression of the dilatation. This thesis consists of four chapters dealing with a specific aspect of the treatment of aortic aneurysm. As new potential surgical therapies needs to be tested, different animal models were extrapolated in sheep. Secondly, electro-actuatable hydrogels were evaluated as these might be used for aneurysm sac occlusion. Thirdly a mechanical and histological study on the effects of external aneurysm support was performed. Finally, a potentially new drug therapy was evaluated in murine models.

Academic collection --- Theses --- Abdominal aneurysm