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Although angiogenesis-the formation of new blood vessels from pre-existing ones-has emerged as an exciting new target for the treatment of many varied disorders, fundamental aspects of this important biological process remain poorly understood. To address the needs of those working in such a dramatically advancing area, Cliff Murray and a panel of experienced investigators have brought together in Angiogenesis Protocols a comprehensive collection of key techniques for assessing the formation of new blood vessels in both whole tissues and cell culture. These readily reproducible methods range from low-cost in vitro assays to cutting-edge in vivo models, such as the dorsal window chamber, which demands high levels of surgical skill as well as relatively expensive, custom-made equipment. The authors have also included details of the associated techniques for the isolation, identification, and culture of microvessel endothelial cells from human adipose tissues and for the transfection and transduction of primary human endothelial cells. Timely and highly practical, Angiogenesis Protocols is a gold-standard resource for today's angiogenesis investigator, providing easy access to a wide variety of proven assays suitable for laboratories with greatly differing technical expertise, materials, and financial resources.

Neovascularization --- Blood-vessels --- Angiogenesis Factor --- Neovascularization, Physiologic. --- Growth --- Molecular aspects --- physiology. --- Blood-vessels -- Growth -- Molecular aspects -- Laboratory manuals. --- Electronic books. -- local. --- Neovascularization -- Laboratory manuals. --- Metaplasia --- Cardiovascular Physiological Processes --- Biological Science Disciplines --- Investigative Techniques --- Angiogenesis Modulating Agents --- Cardiovascular Physiological Phenomena --- Natural Science Disciplines --- Pathologic Processes --- Growth Substances --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Physiological Effects of Drugs --- Circulatory and Respiratory Physiological Phenomena --- Pathological Conditions, Signs and Symptoms --- Disciplines and Occupations --- Phenomena and Processes --- Pharmacologic Actions --- Diseases --- Chemical Actions and Uses --- Chemicals and Drugs --- Angiogenesis Inducing Agents --- Biological Assay --- Physiology --- Neovascularization, Physiologic --- Neovascularization, Pathologic --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Cytology --- Angiology --- Vascular system --- Vasculature --- Cardiovascular system --- Angiogenesis --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Neovascularization - Laboratory manuals --- Blood-vessels - Growth - Molecular aspects - Laboratory manuals

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In 1971, J. Folkman published in the "New England Journal of Medicine" a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis. Beginning in the 1980's, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy. This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.

Neovascularization inhibitors. --- Neovascularization. --- Tumors -- Blood-vessels -- Growth. --- Tumors. --- Tumors --- Neovascularization --- Neovascularization inhibitors --- Cardiovascular Physiological Processes --- Growth Inhibitors --- Metaplasia --- Metabolic Phenomena --- Antineoplastic Agents --- Growth Substances --- Diseases --- Science --- Physiological Effects of Drugs --- Pathologic Processes --- Therapeutic Uses --- Natural Science Disciplines --- Cardiovascular Physiological Phenomena --- Phenomena and Processes --- Pharmacologic Actions --- Circulatory and Respiratory Physiological Phenomena --- Disciplines and Occupations --- Pathological Conditions, Signs and Symptoms --- Chemical Actions and Uses --- Chemicals and Drugs --- Neoplasms --- Angiogenesis Inhibitors --- Angiogenesis Modulating Agents --- Neovascularization, Physiologic --- Neovascularization, Pathologic --- Research --- Metabolism --- Medicine --- Health & Biological Sciences --- Oncology --- Blood-vessels --- Growth --- Blood-vessels. --- Treatment. --- Cancer --- Tumours --- Medicine. --- History. --- Cancer research. --- Oncology. --- Pathology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- History of Science. --- Cell Biology. --- Pathology --- Cysts (Pathology) --- Oncology  . --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Annals --- Auxiliary sciences of history --- Cancer research

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Angiogenesis plays a key role in human physiology and pathophysiology. While necessary for tissue growth and development, uncontrolled angiogenesis plays a role in the progression of certain tumors as well as atherosclerosis. Lack of angiogenesis may be the basis of myocardial ischemia and stroke. Knowledge on the mechanisms of angiogenesis is growing very rapidly, and may lead to important drugs for therapy of a variety of clinical disorders. Experts from around the world have contributed a vast array of data on different aspects of angiogenesis in this volume edited by Professors Mehta and Dhalla. This information will be of immense help to basic scientists, clinicians and those involved in drug development.

Angiogenesis inducing agents. --- Neovascularization -- Therapeutic use. --- Neovascularization, Pathologic. --- Neovascularization. --- Neovascularization --- Metaplasia --- Biological Science Disciplines --- Cardiovascular Physiological Processes --- Growth Substances --- Natural Science Disciplines --- Pathologic Processes --- Cardiovascular Physiological Phenomena --- Physiological Effects of Drugs --- Disciplines and Occupations --- Circulatory and Respiratory Physiological Phenomena --- Pharmacologic Actions --- Pathological Conditions, Signs and Symptoms --- Phenomena and Processes --- Chemical Actions and Uses --- Diseases --- Chemicals and Drugs --- Neovascularization, Pathologic --- Physiology --- Angiogenesis Modulating Agents --- Neovascularization, Physiologic --- Human Anatomy & Physiology --- Health & Biological Sciences --- Anatomy --- Therapeutic use --- Blood-vessels. --- Cardiovascular system. --- Circulatory system --- Vascular system --- Angiology --- Vasculature --- Medicine. --- Cancer research. --- Human physiology. --- Molecular biology. --- Cardiology. --- Proteins. --- Stem cells. --- Biomedicine. --- Human Physiology. --- Cancer Research. --- Receptors. --- Molecular Medicine. --- Stem Cells. --- Blood --- Cardiovascular system --- Circulation --- Oncology. --- Cell receptors. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Tumors --- Heart --- Internal medicine --- Human body --- Health Workforce --- Proteins . --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics --- Cancer research --- Cancer. --- Medicine --- Biology --- Cancer Biology. --- Biomedical Research. --- Stem Cell Biology. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors