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Rapidly emerging at the intersection of nanotechnology, materials science, and molecular biology, the field of nanobiotechnology promises to elucidate many life processes at the molecular-level previously invisible to human inquiry, and thereby dramatically to transform diagnostics, therapy, and drug discovery in this postgenomic world. In Protein Nanotechnology: Protocols, Instrumentation, and Applications, leading experts in nanobiotechnology comprehensively review the most recent advances in instrumentation and methodology, as well as their applications in genomics and proteomics. The authors provide a wide variety of techniques and methods for dealing with protein functions and structures at the nanoscale level, including nanostructured systems, nanomaterials, carbon nanotubes and nanowires, optical nanosensors, and nanoelectrodes. Among the highlights are techniques for the in vivo tracking of biochemical processes using fluorescent molecular probes and nanosensors, and the exploration of biochemical processes and submicroscopic structures of living cells at unprecedented resolutions using near-field optics. Also discussed is the development of nanocarrier methodology for the targeted delivery of drugs whose shells are conjugated with antibodies for targeting specific antigens. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Protein Nanotechnology: Protocols, Instrumentation, and Applications provides investigators a wide variety of readily reproducible techniques and methods for exploring both protein functions and structures at the nanoscale level and their powerful new biological and medical applications.

Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Proteomics --- Proteins --- Genomics --- Nanotechnology --- 577.122 --- Molecular biology --- 577.122 Protein metabolism --- Protein metabolism --- Molecular technology --- Nanoscale technology --- High technology --- Genome research --- Genomes --- Molecular genetics --- Proteids --- Biomolecules --- Polypeptides --- methods --- Research

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Biological Transport. --- Proteins --- 577.112 --- 577.122 --- Biologic Transport --- Transport, Biological --- Transport, Biologic --- Transport Vesicles --- Membrane Transport Proteins --- metabolism. --- secretion. --- Protein metabolism --- BIOLOGICAL TRANSPORT --- PROTEINS --- metabolism --- secretion --- 577.122 Protein metabolism --- 577.112 Proteins --- Metabolism --- Secretion --- Biological transport --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Physiological transport --- Congresses --- Protein --- Biological Transport --- Cells --- Cell Membrane --- Carrier proteins --- Cell nuclei

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"The book aims to provide the reader with a detailed description of protein structure and dynamics, combined with an in-depth discussion of the relationship between both these aspects and protein function. Adopting the structural-biophysical approach, we discuss these in relation to molecular interactions and thermodynamic changes that transpire in this highly complex system. There are several types of textbooks describing protein structure and function. Biochemistry textbooks emphasize the functional aspect of proteins and provide a rather general description of structure and structure-function relationship (SFR). Structural Biology textbooks provide an extensive description of protein structure and also refer to SFR with varying degrees of detail. However, energy-related aspects are often avoided. Molecular biophysics textbooks focus on molecular interactions and thermodynamic aspects of protein structure, but tend to lack detailed description of structural and dynamic aspects, as well as SFR. Our book refers to all of the aforementioned aspects and attempts to provide a unified view. Our energy-oriented approach is manifested throughout the book, whether we discuss structure, dynamics or specific functions of proteins. An extensive discussion of the energetics of protein structure is also given in a chapter dedicated to this topic."--

Proteins --- Physical biochemistry --- Amino Acid Sequence --- Protein Conformation --- Structure-activity relationships --- physiology --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Amino Acid Sequences --- Sequence, Amino Acid --- Sequences, Amino Acid --- Protein Structure, Primary --- Primary Protein Structure --- Primary Protein Structures --- Protein Structures, Primary --- Structure, Primary Protein --- Structures, Primary Protein --- Peptides --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Biophysical chemistry --- Biochemistry --- Physical organic chemistry --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Proteins - Structure-activity relationships --- Proteins - physiology

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Concentrating on the aspects of protein function that are common to the majority of proteins, this collection of methods is brought together for reseachers who are without access to expensive equipment. Using these protocols researchers will be able to get information about the functional properties of any protein. A companion volume, "Protein Structure: A Practical Approach" also edited by Thomas Creighton, provides the methods necessary for the study of protein strucutre.

biochemie --- General biochemistry --- biochemistry --- proteïnen --- Relations structure-activité --- Affinity labeling --- Structure-activity relationships --- Affinity labeling. --- Structure-activity relationships. --- Relations structure-activité --- Biochemistry --- Proteins --- #WSCH:WBIO --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Protein affinity labeling --- Protein binding --- Technique --- Analysis --- physiology --- Basic Sciences. Chemistry --- Technique. --- Analysis. --- physiology. --- Proteins and Enzymes. --- Biochimie --- Protéines --- Analyse --- Electrophoresis. --- Molecular cloning. --- DNA. --- Physiology. --- Biochemistry - Technique --- Proteins - Structure-activity relationships --- Proteins - Affinity labeling --- Proteins - physiology --- DNA --- Genes --- Molecular structure-biological activity relationship

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Proteins --- Nucleic acids --- Plant proteins --- Botanical chemistry --- Plant viruses --- Synthesis --- Congresses --- 577.122 <063> --- 577.123 <063> --- -Nucleic acids --- -Plant proteins --- -Plant viruses --- -Proteins --- -Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Phytopathogenic viruses --- Plant virology --- Phytopathogenic microorganisms --- Viruses --- Virus diseases of plants --- Plant polymers --- Polynucleotides --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Protein metabolism--Congressen --- Nucleic acid metabolism--Congressen --- -Congresses --- Congresses. --- -Protein metabolism--Congressen --- 577.123 <063> Nucleic acid metabolism--Congressen --- 577.122 <063> Protein metabolism--Congressen --- Proteins - Synthesis - Congresses --- Nucleic acids - Synthesis - Congresses --- Plant proteins - Congresses --- Botanical chemistry - Congresses --- Plant viruses - Congresses --- CONFERENCES --- PLANTS --- NUCLEIC ACID SYNTHESIS --- PROTEIN SYNTHESIS