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The purpose of this book is to provide information on apoptotic processes involved in major neoplastic diseases and their translations into emerging anti-cancer strategies. The book is divided into 15 chapters, each of which will be focused on one particular cancer (breast, bladder, cervical, colorectal, esophageal, gastric, laryngeal, liver, lung, nasopharyngeal, pancreatic, prostate, thyroid, leukemia and cutaneous malignant melanoma). A number of established leaders in the field have critically summarized the recent discoveries concerning apoptosis in a particular cancer and its potential for anti-cancer treatment. The book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer, and critically discusses how the emerging anti-cancer strategy can be built by the utilization of the specific carcinogen-related apoptotic pathway. Therefore, this book will be not only for laboratory-based molecular and cell biologists and biochemists in cancer research but also for clinical oncologists and those working in the pharmaceutical and biotechnological industries.

Apoptosis. --- Cancer --Chemotherapy. --- Carcinogenesis. --- Carcinogenesis --- Apoptosis --- Cancer --- Neoplastic Processes --- Cell Death --- Diseases --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cell Physiological Processes --- Pathologic Processes --- Pathological Conditions, Signs and Symptoms --- Cell Physiological Phenomena --- Phenomena and Processes --- Cell Transformation, Neoplastic --- Neoplasms --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Chemotherapy --- Cell death. --- Cell degeneration --- Medicine. --- Cancer research. --- Pharmacology. --- Oncology. --- Surgical oncology. --- Biomedicine. --- Cancer Research. --- Surgical Oncology. --- Pharmacology/Toxicology. --- Cell death --- Cells --- Death (Biology) --- Oncology  . --- Cytology. --- Toxicology. --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Tumors --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Excision --- Treatment --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Drugs --- Pharmacy --- Cancer research --- Physiological effect

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Due to the possibility that petroleum supplies will be exhausted in the next decades to come, more and more attention has been paid to the production of bacterial pl- tics including polyhydroxyalkanoates (PHA), polylactic acid (PLA), poly(butylene succinate) (PBS), biopolyethylene (PE), poly(trimethylene terephthalate) (PTT), and poly(p-phenylene) (PPP). These are well-studied polymers containing at least one monomer synthesized via bacterial transformation. Among them, PHA, PLA and PBS are well known for their biodegradability, whereas PE, PTT and PPP are probably less biodegradable or are less studied in terms of their biodegradability. Over the past years, their properties and appli- tions have been studied in detail and products have been developed. Physical and chemical modifications to reduce their cost or to improve their properties have been conducted. PHA is the only biopolyester family completely synthesized by biological means. They have been investigated by microbiologists, molecular biologists, b- chemists, chemical engineers, chemists, polymer experts, and medical researchers for many years. PHA applications as bioplastics, fine chemicals, implant biomate- als, medicines, and biofuels have been developed. Companies have been est- lished for or involved in PHA related R&D as well as large scale production. It has become clear that PHA and its related technologies form an industrial value chain in fermentation, materials, feeds, and energy to medical fields.

General microbiology --- Histology. Cytology --- Molecular biology --- Medical microbiology, virology, parasitology --- Biotechnology --- toegepaste microbiologie --- microbiologie --- bacteriologie --- biotechnologie --- genetische manipulatie

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Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.

Apoptosis. --- Carcinogenesis -- Molecular aspects. --- Medicine. --- Pathology, Cellullar. --- Apoptosis --- Carcinogenesis --- Cell Death --- Biological Science Disciplines --- Intracellular Signaling Peptides and Proteins --- Neoplastic Processes --- Therapeutic Uses --- Biology --- Neoplasms --- Pathologic Processes --- Cell Physiological Processes --- Proteins --- Natural Science Disciplines --- Pharmacologic Actions --- Peptides --- Chemical Actions and Uses --- Amino Acids, Peptides, and Proteins --- Pathological Conditions, Signs and Symptoms --- Cell Physiological Phenomena --- Diseases --- Disciplines and Occupations --- Phenomena and Processes --- Chemicals and Drugs --- Cell Transformation, Neoplastic --- Antineoplastic Agents --- Apoptosis Regulatory Proteins --- Pharmacology --- Genetics --- Health & Biological Sciences --- Cytology --- Molecular aspects --- Molecular aspects. --- Molecular carcinogenesis --- Entomology. --- Biomedicine. --- Biomedicine general. --- Medicine/Public Health, general. --- Pathology, Molecular --- Cell death --- Insects --- Zoology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.

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Human histology. Human cytology --- Human biochemistry --- Pharmacology. Therapy --- Oncology. Neoplasms --- medische biochemie --- apoptose --- farmacologie --- biochemie --- toxicologie --- oncologie

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Democratization --- Elections --- Taiwan --- Politics and government