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This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

Farmacologia experimental --- Farmacologia clínica --- Bioassaigs --- Assaigs biològics --- Proves biològiques --- Química analítica qualitativa --- Efecte dels medicaments en els éssers humans --- Efectes dels medicaments en els éssers humans --- Farmacologia --- Medicina clínica --- Assaigs clínics de medicaments --- Placebos --- Farmacoepidemiologia --- Efecte dels medicaments sobre els diferents sistemes orgànics dels animals --- Efectes dels medicaments sobre els diferents sistemes orgànics dels animals --- Experimentació humana en medicina --- Pharmacology. --- Medical sciences. --- Drug development. --- Toxicology. --- Pharmacovigilance. --- Preclinical Research. --- Drug Safety and Pharmacovigilance. --- Pharmacoepidemiology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Development of drugs --- Drugs --- New drug development --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Life sciences --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Toxicology --- Development --- Physiological effect

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This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery . There are several advantages for plant-derived therapeutics, including wide availability, diverse pharmacological actions, and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying the efficacy and safety of medicinal plants and phytochemicals in treating human diseases. A plethora of basic studies has also unraveled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products, and drug interactions remain to be systematically documented. Bioprospecting of Tropical Medicinal Plants represents a comprehensive analysis of natural products, mainly medicinal plants and phytochemicals. It includes detailed medicinal properties and pharmacological action from in vitro models to clinical trials. The goal is to present the readers a carefully curated collection of plant-derived natural products and their underlying molecular mechanisms.

Botany. --- Agriculture --- Alternative medicine. --- Pharmacology. --- Agronomy. --- Agriculture. --- Plant Science. --- Agricultural Economics. --- Complementary and Alternative Medicine. --- Economic aspects. --- Farming --- Husbandry --- Industrial arts --- Life sciences --- Food supply --- Land use, Rural --- Crops --- Soil management --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Complementary medicine --- Healing systems --- Systems, Healing --- Systems, Therapeutic --- Therapeutic systems --- Medicine --- Integrative medicine --- Agrarian question --- Agribusiness --- Agricultural economics --- Agricultural production economics --- Production economics, Agricultural --- Botanical science --- Floristic botany --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Biology --- Natural history --- Plants --- Physiological effect --- Economic aspects --- Geobotanical prospecting. --- Materia medica, Vegetable --- Medicinal plants --- Analysis.

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Botany --- History of human medicine --- Physiotherapy. Alternative treatments --- Agronomy --- Agriculture. Animal husbandry. Hunting. Fishery --- farmacologie --- landbouw --- landbouwbeleid --- alternatieve geneeswijzen --- botanie --- planten