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Aufsatzsammlung. --- FC-Rezeptor. --- Fc receptors. --- Fc receptors.

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This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.

Fc receptors. --- Immunology. --- Oncology. --- Emerging infectious diseases. --- Cancer Research. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Tumors --- Immunobiology --- Life sciences --- Serology --- Cancer research. --- Infectious diseases. --- Cancer research

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This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.

Cell receptors --- Fc receptors --- Structure-activity relationships. --- Research. --- Immunology. --- Cell receptors. --- Medicine. --- Receptors. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Immunobiology --- Serology --- Health Workforce --- Receptors, Fc --- Lymphocytes --- Macrophages --- Structure-activity relationships (Biochemistry) --- Proteins . --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics --- Proteins. --- Medicine --- Biology --- Biomedical Research. --- Biological research --- Biomedical research

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This comprehensive volume, written by experts in the field, covers nearly all aspects of ongoing research related to the CD137 pathway. Recent research has shown that the manipulation of CD137 pathway molecules is very promising in the treatment of cancer, viral infection, transplantation rejection and autoimmune diseases in experimental animal models. The volume includes research related to the identification and understanding of functional consequences of CD137 receptor and ligand molecules which represents a major effort in the field of immunology. CD137 Pathway: Immunology and Diseases is an ideal book for immunologists, microbiologists, cancer researchers, molecular biologists, biochemists, and pharmaceutical and biotechnology company scientists.

CD antigens. --- Cell surface antigens. --- Immunological surface markers --- Surface antigens --- Surface markers, Immunological --- Antigens, CD --- CD glycoproteins --- CD molecules --- CD receptors --- CD surface immunoglobulin ligands --- Differentiation antigens, Human leukocyte --- Human leukocyte differentiation antigens --- Leukocyte differentiation antigens, Human --- Medicine. --- Immunology. --- Molecular biology. --- Microbiology. --- Biomedicine. --- Molecular Medicine. --- Tissue-specific antigens --- Cell surface antigens --- Fc receptors --- Glycoproteins --- Microbial biology --- Biology --- Microorganisms --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Immunobiology --- Serology --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Antigens, CD. --- B-Lymphocytes. --- Cluster of Differentiation Antigens --- Cluster of Differentiation Markers --- Differentiation Antigens, Leukocyte, Human --- Leukocyte Differentiation Antigens, Human --- CD Antigens --- B cells --- CD antigens --- Antigens, CD --- B-Lymphocytes --- Congresses. --- congresses. --- B-Cells --- Bursa-Dependent Lymphocytes --- B Cells --- B Lymphocytes --- B-Cell --- B-Lymphocyte --- Bursa Dependent Lymphocytes --- Bursa-Dependent Lymphocyte --- Lymphocyte, Bursa-Dependent --- Lymphocytes, Bursa-Dependent --- CD glycoproteins --- CD molecules --- CD receptors --- CD surface immunoglobulin ligands --- Differentiation antigens, Human leukocyte --- Human leukocyte differentiation antigens --- Leukocyte differentiation antigens, Human --- Cell surface antigens --- Fc receptors --- Glycoproteins --- B lymphocytes --- Bone marrow derived cells --- Bursa equivalent cells --- Antigen presenting cells --- Lymphocytes --- Congresses --- B cells - Congresses. --- CD antigens - Congresses. --- B Cell --- B Lymphocyte --- CD Antigen --- Cluster of Differentiation Antigen --- Cluster of Differentiation Marker --- Antigen Cluster, Differentiation --- Antigen, CD --- Differentiation Antigen Cluster --- Differentiation Marker Cluster --- Marker Cluster, Differentiation --- B-Cells, Lymphocyte --- B Cells, Lymphocyte --- B-Cell, Lymphocyte --- Lymphocyte B-Cell --- Lymphocyte B-Cells