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The search for the most favorable therapeutic ratio – at which ablation of cancer is achieved while normal tissues are conserved – has been modern radiation oncology’s equivalent of the quest for the Holy Grail. Our awareness of the late effects of radiation grew during the past century as new modalities were introduced. Heightened normal tissue reactions accompanied the higher rates of cancer ablation achieved by escalation of radiation doses, accelerated fractionated radiotherapy, and aggressive concurrent chemotherapy and radiation regimens. This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. Written by experts in the field, it addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that it will assist the reader in understanding how to prevent and treat the long-term side-effects of irradiation.

Cancer --- Radiotherapy --- Radiation injuries --- Complications --- Side effects --- Radiation disease --- Radiation sickness --- Radiation syndrome --- Radiation --- Wounds and injuries --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Toxicology --- Radiological services

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Radiation injuries --- Emergency medicine --- Medical emergencies --- Emergency medicine. --- Medical emergencies. --- Radiation injuries. --- Radiation Injuries. --- Emergency Medicine. --- Emergencies. --- Emergency --- Emergency Treatment --- Medicine, Emergency --- Injuries, Radiation --- Radiation Sickness --- Radiation Syndrome --- Injury, Radiation --- Radiation Injury --- Radiation Sicknesses --- Radiation Syndromes --- Sickness, Radiation --- Sicknesses, Radiation --- Syndrome, Radiation --- Syndromes, Radiation --- Atomic Bomb Survivors --- Radioactive Hazard Release --- Emergencies --- First aid in illness and injury --- Medicine --- Critical care medicine --- Disaster medicine --- Radiation disease --- Radiation sickness --- Radiation syndrome --- Radiation --- Wounds and injuries --- Toxicology --- Paramedicine

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Accidents, Occupational. --- Radiation Injuries. --- Sterilization --- Injuries, Radiation --- Radiation Sickness --- Radiation Syndrome --- Injury, Radiation --- Radiation Injury --- Radiation Sicknesses --- Radiation Syndromes --- Sickness, Radiation --- Sicknesses, Radiation --- Syndrome, Radiation --- Syndromes, Radiation --- Radioactive Hazard Release --- Industrial Accidents --- Occupational Accidents --- Accidents, Industrial --- Accident, Industrial --- Accident, Occupational --- Industrial Accident --- Occupational Accident --- Occupational Diseases --- Occupational Injuries --- instrumentation. --- El Salvador. --- Accidents, Occupational --- Radiation Injuries --- instrumentation --- Atomic Bomb Survivors

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Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques: Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node provides a thoroughly illustrated review of the tissue damage and reparative changes associated with standardized irradiation doses in rhesus macaques. In addition to time-sequenced, routinely stained histologic sections, the book presents results of numerous histochemical, immunohistochemical and chromogenic in-situ stains that provide insights into the pathogenesis of radiation-associated tissue injury and repair. This book is compiled and written by a board-certified veterinary pathologist with more than 40 years of experience in the interpretation of experimentally induced tissue alterations in laboratory animals.

Radiation injuries. --- Toxicology --- Histology, Pathological. --- Animal models. --- Histopathology --- Pathological histology --- Histology --- Pathology --- Animal models in research --- Toxicology, Experimental --- Alternative toxicity testing --- Radiation disease --- Radiation sickness --- Radiation syndrome --- Radiation --- Wounds and injuries --- Rhesus monkey --- Histology, Pathological --- Acute Radiation Syndrome --- Macaca mulatta --- Radiation Injuries, Experimental --- Toxicology.

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This book covers all aspects of chronic radiation syndrome (CRS) based on observations in a unique sample of residents of the Techa riverside villages in the southern Urals who were exposed to radioactive contamination in the 1950s owing to releases of liquid radioactive wastes from Mayak Production Association, which produced plutonium for weapons. In total, 940 cases of CRS were diagnosed in this population and these patients were subjected to detailed analysis. The opening chapters address the definition and classification of CRS, epidemiology and pathogenesis, covering molecular and cellular mechanisms, radioadaptation, and the role of tissue reactions. The pathoanatomy of CRS during the development and recovery stages is discussed for all organ systems. Clinical manifestations of CRS at the different stages are then described in detail and the dynamics of hematopoietic changes are thoroughly examined. In the following chapters, principles of diagnosis (including assessment of the exposure doses to critical organs) and differential diagnosis from a wide range of other conditions are discussed and current and potential treatment options, described. The medical and social rehabilitation of persons with CRS is also covered. This book, which casts new light on the condition, will be of value for all practitioners and researchers with an interest in CRS.

Hematology. --- Medicine. --- Nuclear medicine. --- Radiation -- Physiological effect. --- Radiotherapy. --- Disease Attributes --- Wounds and Injuries --- Radiation Effects --- Pathologic Processes --- Radiologic Health --- Diseases --- Public Health --- Pathological Conditions, Signs and Symptoms --- Environment and Public Health --- Health Care --- Chronic Disease --- Radiation Injuries --- Radiation injuries. --- Haematology --- Radiation therapy --- Radiation disease --- Radiation sickness --- Radiation syndrome --- Medicine & Public Health. --- Internal medicine --- Blood --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Radiological services --- Radiation --- Wounds and injuries --- Toxicology