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Blood flow --- Blood Flow Velocity --- Measurement
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This dissertation by Hanna Jonasson presents a model-based quantitative assessment of skin blood flow and oxygen saturation using combined diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF). The research aims to develop an optical method for accurately measuring oxygen saturation, red blood cell (RBC) tissue fraction, and speed-resolved perfusion in absolute units. The study evaluates different calibration methods and model assumptions in optical phantoms and skin measurements. The integrated system demonstrates potential clinical applications for assessing microvascular function in both healthy individuals and patients with type 2 diabetes, showing reduced RBC tissue fraction and nutritive blood flow in patients compared to controls.
Microcirculation. --- Blood flow. --- Microcirculation --- Blood flow
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This dissertation by Arpan Ghosh focuses on the mathematical modeling of fluid flow through thin, curved pipes, with particular application to hemodynamics, the study of blood flow in the circulatory system. The work aims to develop simplified models that can aid medical practitioners in diagnosing abnormalities in blood flow. It is composed of four articles, each addressing different aspects of the modeling process. The first article presents a model for the elastic behavior of the pipe walls, considering their laminate structure and interaction with surrounding materials. The second article models blood flow through moderately curved and elastic blood vessels using linearized Navier-Stokes equations. The third article derives a simplified model for a false aneurysm, while the final article discusses a modified Reynolds equation for fluid flow through narrow, curvilinear tubes. The thesis is intended for researchers and practitioners in mathematics and applied sciences, particularly those interested in fluid dynamics and biomedical engineering.
Hemodynamics. --- Blood flow. --- Hemodynamics --- Blood flow
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