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Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of

Nitric oxide --- Nitrogen compounds. --- Chemicals --- Pathophysiology.

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"This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical applications of these concepts. The book comprises in-depth reviews by leading experts in several major areas: recent basic science discoveries about angiogenesis modifiers (semaphorins, ephrins and nitric oxide, for which the Nobel Prize was awarded); arterial guidance; clinical applications of new angiogenic factors (HGF, HIF and eNOS); and basic and clinical advancement of anti-angiogenic molecules for the treatment of cancer and macular degeneration (tyrosine kinase inhibitors and NO). These topics, especially their unique combination presented in this volume, are not found in any other current books on angiogenesis. This makes the book a must-read for readers both interested and actively involved in the most recent advances in basic principles and clinical applications of angiogenesis."

Neovascularization. --- Vascular endothelial growth factors. --- Vascular endothelial growth factors --- Neovascularization inhibitors. --- Angiogenesis inhibitors --- Tumor angiogenesis inhibitors --- Antineoplastic agents --- Angiogenic factors --- Angiogenic proteins --- Endothelial growth factors, Vascular --- VEGFs (Proteins) --- Growth factors --- Blood-vessels --- Therapeutic use. --- Growth

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Gel permeation chromatography --- Chromatographie sur gel --- Chromatography, Gel permeation --- Chromatography, Size exclusion --- Gel filtration chromatography --- SEC (Chromatographic analysis) --- Size exclusion chromatography --- Steric exclusion liquid chromatography --- Chromatographic analysis --- Gel permeation chromatography.

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Advances in genetics, molecular biology and gene delivery technologies in recent years have lead to new gene therapy strategies to treat a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems, as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field.

Gene therapy --- Genetic Therapy --- trends --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Human genetics. --- Cancer research. --- Oncology  . --- Neurology . --- Molecular biology. --- Virology. --- Human Genetics. --- Cancer Research. --- Oncology. --- Neurology. --- Molecular Medicine. --- Microbiology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medicine --- Nervous system --- Neuropsychiatry --- Tumors --- Cancer research --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Diseases --- Gene therapy - Congresses --- Genetic Therapy - trends - congresses --- Therapie genique