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Peroxisomes are cell organelles that have functions for the provision of homeostasis and sustainable cellular health. They are indispensable for lipid metabolism and free radical detoxification. A disruption in the peroxisomal pathway can cause irreparable problems or death for the organism. This book provides a comprehensive overview of peroxisomes, including their role in cell health and diseases such as cancer.
Peroxisomes. --- Peroxidosomes --- Peroxysoma --- Microbodies
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Human histology. Human cytology --- General biochemistry --- Animal biochemistry --- Peroxidosomes --- Peroxisoma --- Peroxisomen --- Peroxisomes --- Péroxisomes --- Biologie cellulaire --- Celbiologie --- Peroxisomes.
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Peroxisomes --- Glyoxysomes --- Cytochemistry --- Congresses --- 576.311.344 --- #WPLT:dd.prof.J.Vendrig --- Lysosomes. Peroxisomes. --- 576.311.344 Lysosomes. Peroxisomes. --- Peroxidosomes --- Peroxysoma --- Microbodies --- Cell organelles --- Cell chemistry --- Biochemistry --- Cytology --- Lysosomes. Peroxisomes --- Peroxisomes - Congresses --- Glyoxysomes - Congresses --- Cytochemistry - Congresses
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This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.
Neurosciences. --- Medicine. --- Proteins . --- Biology—Technique. --- Biomedicine, general. --- Protein Science. --- Biological Techniques. --- Health Workforce --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Peroxisomes. --- Peroxidosomes --- Peroxysoma --- Microbodies
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In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.
Peroxisomes. --- Life sciences. --- Cytology. --- Biosciences --- Sciences, Life --- Science --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Peroxidosomes --- Peroxysoma --- Microbodies --- Cytology --- Cell membranes. --- Cell Biology. --- Biological Techniques. --- Membrane Biology. --- Research --- Methodology. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Cell biology. --- Biology—Technique. --- Cell membranes .
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Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. Today it is known that fatty acid β-oxidation is a general feature of virtually all types of peroxisomes, but in higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid α-oxidation, and glyoxylate detoxification, and in humans peroxisomes are associated with several important genetic diseases. Among the different new roles for human peroxisomes discovered in recent years are antiviral innate immunity, peptide hormone metabolism, brain aging and Alzheimer’s disease, and age-related diseases. In fungi, new findings have broadened the number of secondary metabolites that are synthesized in peroxisomes, such as antibiotics and several toxins, and have evidenced their involvement in biotin biosynthesis, fungal development and plant pathogenesis. In plants, peroxisomes carry out different functions, apart from fatty acid β-oxidation, mainly including photorespiration, metabolism of reactive oxygen, nitrogen and sulfur species, photomorphogenesis, biosynthesis of phytohormones, senescence, and defense against pathogens and hervibores. Two important characteristics of peroxisomes are their metabolic plasticity and capacity of sharing metabolic pathways with other cell compartments. In recent years, a function for peroxisomes as key centers of the cellular-signaling apparatus which could influence the regulatory network of the cell has been postulated. The diverse key physiological functions that have been demonstrated for peroxisomes from different origins strongly indicate the interest of studying the role of peroxisomes as a cellular source of different signaling molecules. This book presents recent advances in the function and metabolism of peroxisomes from human, animal, fungal and plant origin and their metabolic interconnection with other cell compartments, showing the central role played by peroxisomes as cell generators of different signaling molecules involved in distinct processes of high physiological importance.
Cellular signal transduction. --- Gene expression. --- Metabolism. --- Peroxisomes. --- Peroxisomes --- Cellular signal transduction --- Metabolism --- Peroxidosomes --- Peroxysoma --- Medicine. --- Biochemistry. --- Plant biochemistry. --- Proteomics. --- Cell biology. --- Cell physiology. --- Biomedicine. --- Biomedicine general. --- Cell Biology. --- Cell Physiology. --- Animal Biochemistry. --- Plant Biochemistry. --- Microbodies --- Cytology. --- Molecular biology --- Proteins --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell function --- Cytology --- Physiology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Health Workforce --- Biomedicine, general. --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Medicine --- Botanical chemistry. --- Proteins. --- Biomedical Research. --- Chemical Biology. --- Protein Biochemistry. --- Research. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Biological research --- Biomedical research
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All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described. As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.
Life sciences. --- Peroxisome proliferator-Activated receptors. --- Peroxisomes -- Receptors. --- Peroxisomes --- Biological Science Disciplines --- Receptors, Cytoplasmic and Nuclear --- DNA-Binding Proteins --- Natural Science Disciplines --- Disciplines and Occupations --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Peroxisome Proliferator-Activated Receptors --- Physiology --- Pharmacology --- Chemistry --- Biology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Biochemistry --- Biology - General --- Receptors --- Peroxisomes. --- Hormone receptors. --- Hormones --- Receptors, Hormone --- Peroxidosomes --- Peroxysoma --- Biochemistry. --- Proteins. --- Life Sciences. --- Biochemistry, general. --- Receptors. --- Cell receptors --- Microbodies --- Cell receptors. --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Composition --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics
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Peroxisomes --- Peroxisomal disorders --- Peroxisomal Disorders. --- Peroxysomes. --- Pathologie peroxysomale. --- Peroxisomal disorders. --- Peroxisomes. --- Metabolism. --- Molecular Biology. --- Peroxidosomes --- Peroxysoma --- Adrenoleukodystrophy, Autosomal Neonatal Form --- Adrenoleukodystrophy, Autosomal, Neonatal Form --- Hyperpipecolatemia --- Neonatal Adrenoleukodystrophy --- Peroxisomal Dysfunction, General --- Peroxisomal Dysfunction, Multiple --- Peroxisomal Dysfunction, Single --- Adrenoleukodystrophy, Neonatal --- Hyperpipecolic Acidemia --- Acidemia, Hyperpipecolic --- Acidemias, Hyperpipecolic --- Adrenoleukodystrophies, Neonatal --- Dysfunction, General Peroxisomal --- Dysfunction, Multiple Peroxisomal --- Dysfunction, Single Peroxisomal --- Dysfunctions, General Peroxisomal --- Dysfunctions, Multiple Peroxisomal --- Dysfunctions, Single Peroxisomal --- General Peroxisomal Dysfunction --- General Peroxisomal Dysfunctions --- Hyperpipecolic Acidemias --- Multiple Peroxisomal Dysfunction --- Multiple Peroxisomal Dysfunctions --- Neonatal Adrenoleukodystrophies --- Peroxisomal Disorder --- Peroxisomal Dysfunctions, General --- Peroxisomal Dysfunctions, Multiple --- Peroxisomal Dysfunctions, Single --- Single Peroxisomal Dysfunction --- Single Peroxisomal Dysfunctions --- Peroxisomal diseases --- Peroxysomal disorders --- Diseases --- Peroxisomal Disorders --- PPAR alpha --- PPAR-beta --- PPAR delta --- PPAR gamma --- peroxisome proliferator-activated receptors --- Microbodies --- Central nervous system --- Metabolism, Inborn errors of --- Pediatric neurology --- Human physiology --- Life Sciences --- Biology --- ppar alpha --- ppar-beta --- ppar delta --- ppar gamma --- Peroxysomes --- Pathologie peroxysomale --- Glycosomes --- Glycosome --- Microbody --- Peroxisome Proliferators
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This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.
Human physiology. --- Cell biology. --- Cell physiology. --- Biochemistry. --- Human Physiology. --- Cell Biology. --- Cell Physiology. --- Animal Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell function --- Cytology --- Physiology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Human biology --- Human body --- Composition --- Peroxisomes. --- Peroxidosomes --- Peroxysoma --- Microbodies --- Bioquímica --- Malalties --- Malaltia --- Medicina --- Discapacitat física --- Malalties cardiovasculars --- Malalties constitucionals --- Malalties de l'aparell digestiu --- Malalties de l'aparell genital --- Malalties de l'aparell respiratori --- Malalties de la pell --- Malalties del sistema nerviós --- Malalties dels animals --- Malalties hematològiques --- Malalties hereditàries --- Malalties de l'aparell locomotor --- Malalties d'origen nutricional --- Malalties iatrogèniques --- Malalties immunitàries --- Malalties otorrinolaringològiques --- Malalties rares --- Oftalmopaties --- Serveis d'urgències mèdiques --- Síndromes --- Trastorns de la nutrició --- Trastorns del metabolisme --- Epidemiologia --- Química biològica --- Química fisiològica --- Biologia --- Química --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica clínica --- Bioquímica física --- Bioquímica quàntica --- Biosíntesi --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Metabolisme --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química clínica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Histoquímica
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