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This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

Parasitology. --- Biomechanics. --- Proteins . --- Bioinformatics. --- Protein Science. --- Protein Structure. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Biological mechanics --- Mechanical properties of biological structures --- Biophysics --- Mechanics --- Contractility (Biology) --- Data processing --- Actin. --- Actomyosin --- Enginyeria de proteïnes --- Disseny de proteïnes --- Tecnologia de proteïnes --- Enginyeria bioquímica --- Enginyeria genètica

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This book provides practical guidance on all aspects of reverse phase protein array (RPPA) technology, which permits the quantification of protein levels in cell or tissue lysates. In addition, the latest results are presented from laboratories across the world where experts are successfully running the challenging RPPA data platform. After an introductory chapter by the inventor of the RPPA technique, the demanding task of lysate preparation is explained. Subsequent chapters review printing platforms and analytical platforms and discuss antibody screening in detail. The role of RPPA data in integrative analyses is thoroughly examined, and the various applications of RPPA, for example to identify molecular targeting drugs or evaluate cancer drug efficacy, are discussed with reference to the latest knowledge. It is hoped that the book will foster the implementation of RPPA by documenting the practical details of the technology and by revealing its great potential. It will be of high value for researchers who plan to build an RPPA platform in their institute and for researchers, clinicians, and companies who use RPPA through collaboration with an existing RPPA facility.

Proteins. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Molecular biology. --- Cancer research. --- Proteins . --- Biomedical engineering. --- Microarrays. --- Pharmaceutical technology. --- Molecular Medicine. --- Cancer Research. --- Protein Science. --- Biomedical Engineering/Biotechnology. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Systems biology --- Enginyeria de proteïnes --- Tecnologia farmacèutica --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia --- Disseny de proteïnes --- Tecnologia de proteïnes --- Enginyeria bioquímica --- Enginyeria genètica