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Rats with quinolinic acid lesions of the medial or lateral caudate-putamen (CPu) and controls were tested for performance of a previously learned auditory conditional response association task. The task involved the selection of two possible responses when presented with one of two different tones. Results indicated that lesions of either the medial or the lateral CPu produced a sustained deficit in the auditory conditional response association task. Only the lateral Cpu lesioned rats exhibited transient motor problems immediately following surgery but these problems did not interfere with the execution of the appropriate responses. It is suggested that both the medial and the lateral CPu are involved in response selection and response separation within egocentric space. (C) 2001 Academic Press
Acquisition. --- Association. --- Auditory. --- Basal ganglia. --- City. --- Control. --- Dorsal striatum. --- Impairments. --- Induced lesions. --- Lesion. --- Lesions. --- Memory. --- Nucleus. --- Performance. --- Prefrontal cortex. --- Rat. --- Rats. --- Response. --- Responses. --- Selection. --- Separation. --- Space. --- Surgery. --- Task. --- Time. --- Triple dissociation.
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The present experiments investigated the role of the prelimbic-infralimbic areas in behavioral flexibility using a place-response learning paradigm. All rats received a bilateral cannula implant aimed at the prelimbic-infralimbic areas. To examine the role of the prelimbic-infralimbic areas in shifting strategies, rats were tested on a place and a response discrimination in a cross-maze. Some rats were tested on the place version first followed by the response version. The procedure for the other rats was reversed. Infusions of 2% tetracaine into the prelimbic-infralimbic areas did not impair acquisition of the place or response discriminations. Prelimbic-infralimbic inactivation did impair learning when rats were switched from one discrimination to the other (cross-modal shift). To investigate the role of the prelimbic-infralimbic areas in intramodal shifts (reversal learning), one group of rats was tested on a place reversal and another group tested on a response reversal. Prelimbic-infralimbic inactivation did not impair place or response intramodal shifts. Some rats that completed testing on a particular version in the cross-modal and intramodal experiments were tested on the same version in a new room for 3 d. The transfer tests revealed that rats use a spatial strategy on the place version and an egocentric response strategy on the response version. Overall, these results suggest that the prelimbic-infralimbic areas are important for behavioral flexibility involving crossmodal but not intramodal shifts
Acquisition. --- Animal-models. --- Anterior cingulate. --- Area. --- Attentional set shifting. --- Cannula. --- Caudate-nucleus. --- City. --- Cortex. --- Discrimination. --- Double dissociation. --- Electrolytic lesions. --- Experiment. --- Experiments. --- Flexibility. --- Group. --- Hippocampal. --- Infralimbic. --- Involvement. --- Learning. --- Prefrontal cortex. --- Prelimbic. --- Rat. --- Rats. --- Response. --- Reversal learning. --- Rodent. --- Spatial. --- Strategies. --- Strategy. --- Tasks. --- Test. --- Tests. --- Tetracaine. --- Working-memory.
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