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Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions - from molecules in gene regulatory networks to species in ecological networks - and the often-incomplete state of system knowledge, such as the unknown values of kinetic parameters for biochemical reactions. Boolean networks have emerged as a powerful tool for modeling these systems. This Element provides a methodological overview of Boolean network models of biological systems. After a brief introduction, the authors describe the process of building, analyzing, and validating a Boolean model. They then present the use of the model to make predictions about the system's response to perturbations and about how to control its behavior. The Element emphasizes the interplay between structural and dynamical properties of Boolean networks and illustrates them in three case studies from disparate levels of biological organization.
Systems biology --- Bioinformatics. --- Mathematical models.
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This second edition provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Drug Discovery and Design, Second Edition aims to effectively utilize computational methodologies in discovery and design of novel drugs.
Pharmacology. --- Chemistry --- Bioinformatics. --- Computational Chemistry. --- Data processing.
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This book constitutes the refereed proceedings of the 20th International Symposium on Bioinformatics Research and Applications, ISBRA 2024, held in Kunming, China, in July 19–21, 2024. The 93 full papers included in this book were carefully reviewed and selected from 236 submissions. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications.
Bioinformatics --- Bioinformatics. --- Artificial intelligence. --- Computer engineering. --- Computer networks. --- Artificial Intelligence. --- Computer Engineering and Networks.
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This book constitutes the refereed proceedings of the 20th International Symposium on Bioinformatics Research and Applications, ISBRA 2024, held in Kunming, China, in July 19–21, 2024. The 93 full papers included in this book were carefully reviewed and selected from 236 submissions. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications.
Bioinformatics --- Bioinformatics. --- Artificial intelligence. --- Computer engineering. --- Computer networks. --- Artificial Intelligence. --- Computer Engineering and Networks.
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This book constitutes the refereed proceedings of the 20th International Symposium on Bioinformatics Research and Applications, ISBRA 2024, held in Kunming, China, in July 19–21, 2024. The 93 full papers included in this book were carefully reviewed and selected from 236 submissions. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications.
Bioinformatics --- Bioinformatics. --- Research. --- Artificial intelligence. --- Computer engineering. --- Computer networks. --- Artificial Intelligence. --- Computer Engineering and Networks.
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This two-volume set LNBI 14881-14882 constitutes - in conjunction with the 13-volume set LNCS 14862-14874 and the 6-volume set LNAI 14875-14880 - the refereed proceedings of the 20th International Conference on Intelligent Computing, ICIC 2024, held in Tianjin, China, during August 5-8, 2024. The total of 863 regular papers were carefully reviewed and selected from 2189 submissions. The intelligent computing annual conference primarily aims to promote research, development and application of advanced intelligent computing techniques by providing a vibrant and effective forum across a variety of disciplines. This conference has a further aim of increasing the awareness of industry of advanced intelligent computing techniques and the economic benefits that can be gained by implementing them. The intelligent computing technology includes a range of techniques such as Artificial Intelligence, Pattern Recognition, Evolutionary Computing, Informatics Theories and Applications, Computational Neuroscience & Bioscience, Soft Computing, Human Computer Interface Issues, etc. .
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This two-volume set LNBI 14881-14882 constitutes - in conjunction with the 13-volume set LNCS 14862-14874 and the 6-volume set LNAI 14875-14880 - the refereed proceedings of the 20th International Conference on Intelligent Computing, ICIC 2024, held in Tianjin, China, during August 5-8, 2024. The total of 863 regular papers were carefully reviewed and selected from 2189 submissions. The intelligent computing annual conference primarily aims to promote research, development and application of advanced intelligent computing techniques by providing a vibrant and effective forum across a variety of disciplines. This conference has a further aim of increasing the awareness of industry of advanced intelligent computing techniques and the economic benefits that can be gained by implementing them. The intelligent computing technology includes a range of techniques such as Artificial Intelligence, Pattern Recognition, Evolutionary Computing, Informatics Theories and Applications, Computational Neuroscience & Bioscience, Soft Computing, Human Computer Interface Issues, etc. .
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This book presents cutting-edge research and developments in the field of biomedical engineering, with a special emphasis on results achieved in Vietnam and neighboring low- and middle-income countries. Covering both fundamental and applied research, and focusing on the theme of “Translational Healthcare Technology from Advanced to Low and Middle Income Countries in the Era of Covid and Digital Transformation”, it reports on the design, fabrication, and application of low-cost and portable medical devices, biosensors, and microfluidic devices, on improved methods for biological data acquisition and analysis, on nanoparticles for biological applications, and on new achievements in biomechanics, tissue engineering, and regeneration. It describes the developments of molecular and cellular biology techniques, neuroengineering techniques, and statistical and computational methods, including artificial intelligence, for biomedical applications. It also discusses strategies to addresssome relevant issues in biomedical education and entrepreneurship. Gathering the proceedings of the 9th International Conference on The Development of Biomedical Engineering in Vietnam, BME 9, held on December 27-29, 2022, in Ho Chi Minh, Vietnam, the book offers important answers to current challenges in the field and a source of inspiration for scientists, engineers, and researchers with various backgrounds working in different research institutes, companies, and countries.
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