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This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Cancer—Animal models. --- Tumors—Classification. --- Tumors—Immunological aspects. --- Cancer Models. --- Cancer Staging. --- Tumour Immunology.

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Our knowledge of the ancient theatre is limited by the textual and iconographic character of the evidence available to us: we cannot watch or otherwise experience an Athenian tragedy or comedy. These essays, by a distinguished group of international scholars, bridge the gap between the surviving literary and iconographic evidence and the realities of performance on the ancient Greek stage. This ambitious goal is reached by means of a detailed examination of several case-studies: the construction of dramatic space in Sophocles’ Antigone; the significance of the use of deictic pronouns in Sophocles’ Trachiniae; the theatrical and religious dynamics of the appearance of divine figures on stage; the relationship between the victory celebrations at the end of Aristophanic comedies and their counterparts in the after-performance real world; the investigation of nude or semi-nude female characters in Aristophanes; the staging of Clouds and the opening scene of Acharnians; the meditation on the metapoetics of the use of props in 5th-century comedy; the relationship between performance context and text through a close reading of a number of Aristophanic fragments; the way the scholia vetera on Frogs imagine and use questions of staging practice; and the potential Aeschylean authorship of some of stage-direction traceable in Aeschylus’ Eumenides and Diktoulkoi.

Greek dram --- Theater --- History and criticism. --- History --- Greek Drama. --- performance. --- staging. --- text.