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The purpose of this primer is to provide students, teachers as well as academic and industry researchers with a succinct account of the chemical and structural features of chromatin and the role that these features play in the maintenance and function of the genetic material. It is universally accepted that DNA is the carrier of the genetic information that is transmitted from parents to their offspring and that it is responsible for the anatomy, physiology and behavior of all individuals throughout development and adult life. Yet, how this information is retrieved and used selectively to allow a fertilized egg to become an organism made up of myriads of different cells and tissues is not as evident and easily understood. Dr Lucchesi, an internationally known researcher and teacher, provides an easily opened window into the role that the complex of proteins and nucleic acids that are associated with the DNA play in mediating gene expression and in responding to environmental circumstances.

Chromatin --- Gene Expression

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This book covers various state-of-the-art techniques regarding the associations between transcription factors (TFs) and genes, with a focus on providing methodological and practical references for researchers. The contents cover diverse protocols and summaries of TFs including screening of TF-DNA interactions, detection of open chromatin regions, identification of epigenetic regulations, engineering TFs with genome editing tools, detection of transcriptional activities, computational analysis of TF networks, functions and druggabilities of TFs in biomedical research, and much more. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice from the experts to ensure successful research results. Authoritative and cutting-edge, Transcription Factor Regulatory Networks aims to benefit readers who are interested in using state-of-the-art techniques to study TFs and their myriad effects in cellular life.

Genetic transcription. --- Biology—Technique. --- Gene expression. --- Gene Transcription. --- Gene Expression Analysis. --- Transcription (Genetics) --- Genetic code --- Genes --- Genetic regulation --- Expression

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"Computational Intelligence in Cancer Diagnosis: Progress and Challenges provides insights into the current strength and weaknesses of different applications and research findings on computational intelligence in cancer research. The book improves the exchange of ideas and coherence among various computational intelligence methods and enhances the relevance and exploitation of application areas for both experienced and novice end-users. Topics discussed include neural networks, fuzzy logic, connectionist systems, genetic algorithms, evolutionary computation, cellular automata, self-organizing systems, soft computing, fuzzy systems, and hybrid intelligent systems.The book's chapters are written by international experts from both cancer research, oncology and computational sides to cover different aspects and make it comprehensible for readers with no background on informatics. Key Features: Contains updated information about advanced computational intelligence, spanning the areas of neural networks, fuzzy logic, connectionist systems, genetic algorithms, evolutionary computation, cellular automata, self-organizing systems, soft computing, fuzzy systems, and hybrid intelligent systems in diagnosing cancer diseases. Discusses several cancer types, including their detection, treatment and prevention. Presents case studies that illustrate the applications of intelligent computing in data analysis to help readers to analyze and advance their research in cancer"--Provided by publisher.

Computational intelligence. --- Artificial Intelligence. --- Neoplasms --- Gene Expression Profiling. --- diagnosis. --- Intelligence, Computational --- Artificial intelligence --- Soft computing --- Gene Expression Monitoring --- Transcriptome Analysis --- Gene Expression Analysis --- Gene Expression Pattern Analysis --- Transcript Expression Analysis --- Transcriptome Profiling --- Transcriptomics --- mRNA Differential Display --- Analyses, Gene Expression --- Analyses, Transcript Expression --- Analyses, Transcriptome --- Analysis, Gene Expression --- Analysis, Transcript Expression --- Analysis, Transcriptome --- Differential Display, mRNA --- Differential Displays, mRNA --- Expression Analyses, Gene --- Expression Analysis, Gene --- Gene Expression Analyses --- Gene Expression Monitorings --- Gene Expression Profilings --- Monitoring, Gene Expression --- Monitorings, Gene Expression --- Profiling, Gene Expression --- Profiling, Transcriptome --- Profilings, Gene Expression --- Profilings, Transcriptome --- Transcript Expression Analyses --- Transcriptome Analyses --- Transcriptome Profilings --- mRNA Differential Displays --- Gene Expression --- Oligonucleotide Array Sequence Analysis --- Transcriptome --- Subtractive Hybridization Techniques --- Computational Intelligence --- AI (Artificial Intelligence) --- Computer Reasoning --- Computer Vision Systems --- Knowledge Acquisition (Computer) --- Knowledge Representation (Computer) --- Machine Intelligence --- Acquisition, Knowledge (Computer) --- Computer Vision System --- Intelligence, Artificial --- Intelligence, Machine --- Knowledge Representations (Computer) --- Reasoning, Computer --- Representation, Knowledge (Computer) --- System, Computer Vision --- Systems, Computer Vision --- Vision System, Computer --- Vision Systems, Computer --- Heuristics --- Cancer --- Artificial Intelligence --- Diagnosis --- Data processing. --- diagnosis

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'Females are Mosaics' focuses on the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease.

X chromosome. --- Mosaicism. --- Sex determination, Genetic. --- Sex-linkage (Genetics) --- Linkage (Genetics) --- Sex chromosomes --- Chromosomal sex determination --- Determination of sex, Genetic --- Genetic determination of sex --- Genotypic sex determination --- Sex --- Sex determination, Genetic --- Gene expression --- Sex determination --- Chromosomal mosaicism --- Chromosome mosaics --- Mosaics (Genetics) --- Mosaics, Chromosome --- Genetics --- Chromosome X --- Cause and determination --- X Chromosome Inactivation --- Genetic Diseases, X-Linked. --- Sex Factors. --- physiology. --- Genetic sex determination.