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This book illustrates the importance and advances of the disease model for malaria, a globally affected public health problem. This book provides comprehensive information on the malaria biology in a liver and all in vitro platforms for liver-stage malaria, including principles, protocols, applications for disease modeling and drug screening, and their limitations. The initial chapter describes the basis of stem cells in liver generation during development and in adults. The subsequent chapters highlight recent and emerging advances in liver organoid and liver-on-a-chip in modeling malaria. The book presents current protocols and methods to generate liver organoid and liver-on-a-chip together with their advantages and limitations. Toward the end, the book examines the humanized mouse model of liver-stage malaria using ectopic artificial livers regarding novel readout modalities. The recent advancement and challenges in combining liver-on-a-chip technology with biosensors are highlighted for assessing hepatocyte development viability and functions. The book elucidates the potential of these 3D models to understand the biological complexity of cellular and molecular mechanisms involved in Plasmodium development in the liver, toolboxes to investigate parasite deployment in the 3D models, and to implement in drug discovery. Finally, the book discusses the future directions and challenges in the applications of liver organoids and liver on-chip in the biology of live-stage malaria. This book is helpful for researchers and scientists in the field of parasitology, cell biology, tissue engineering, and pharmacology.

Parasitology. --- Medical microbiology. --- Stem cells. --- Medical Microbiology. --- Stem Cell Biology. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Biology --- Medical Microbiology --- Cytology --- Medical Parasitology --- Medical --- Science

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This book is quick guide on the hematopoietic stem cell transplant (SCT), also called bone marrow transplant (BMT) - an evolving field of hematology and hemato-oncology. This book covers the various types of stem cell transplants like autologous and allogeneic stem cell transplants, indications, ways of doing a transplant, and stem cell transplants basic principles. Written in a question-answer format, readers will find it more interesting as one question sequentially leads to another. This book explains the complications of SCT in individual chapters along with the biology of T cells which are the most important cells involved in the success of SCT This book is beneficial to the budding hematologists, oncologists, and postgraduates interested in SCT and helps students in their exams. The book would be helpful for readers globally as SCT is a procedure done worldwide and is an ever-increasing field for treating various benign and malignant hematological diseases.

Hematology. --- Hematopoietic system. --- Stem cells. --- Haematopoietic System. --- Stem Cell Biology. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Hemopoietic system --- Hematopoiesis --- Haematology --- Internal medicine --- Blood --- Diseases

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This book focuses on the recent innovations and therapeutic potentials of regenerative medicine and discusses the applications of stem cells, biomaterials, and tissue engineering in regenerative medicine. The book covers essential aspects of regenerative medicine, including tissue microenvironment, immunological perspectives, stem, and non-stem cell-mediated approaches, imaging techniques, biomarkers, and 3D printing technology. It also reviews the applications of biosensing technologies in regenerative medicine, including biomanufacturing, organ-on-a-chip technologies, and as indicators of therapeutic efficacy. Further, it focuses on the regenerative medicine approaches for diseases of the central nervous system. It also provides the therapeutic potential of regenerative medicine to improve soft tissue and wound healing, cardiovascular, neural, bone, and orofacial regeneration.

Regenerative medicine. --- Stem cells. --- Nervous system—Regeneration. --- Biomaterials. --- Cells. --- Regenerative Medicine and Tissue Engineering. --- Stem Cell Biology. --- Regeneration and Repair in the Nervous System. --- Biomaterials-Cells. --- Organisms --- Cytology --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Medicine --- Regeneration (Biology)

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This book reviews the cellular and non-cellular components of human breast milk and their contribution to infant growth and development. It also discusses various cellular growth factors in breast milk, including stem cells and their significance in promoting optimal growth, immunity and regeneration in neonates and in mitigating several neonatal diseases. Further, the book examines variations in the macronutrient concentrations of human milk in different lactation stages and maternal factors. It also describes the potential of antimicrobial proteins/peptides in human milk to provide innate immunity to infants. Lastly, it explores the regenerative therapeutic applications of breast milk cells in feeding infants.

Stem cells. --- Gynecology. --- Immunology. --- Human physiology. --- Stem Cell Biology. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Immunobiology --- Life sciences --- Serology --- Gynaecology --- Medicine --- Generative organs, Female --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Diseases

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Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 18th volume of a continuing series.

Cytology. --- Stem cells. --- Regenerative medicine. --- Molecular biology. --- Epigenetics. --- Cell Biology. --- Stem Cell Biology. --- Regenerative Medicine and Tissue Engineering. --- Molecular Biology. --- Genetics --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medicine --- Regeneration (Biology) --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Cell biology --- Cellular biology --- Biology --- Tissue engineering. --- Tissues --- Differentiation. --- Histology --- Organs (Anatomy) --- Biomedical engineering --- Regenerative medicine --- Tissue culture