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The recent advances in the field of molecular diagnostic techniques have led to the identification of targetable alterations prompting a paradigm shift in the management of non-small cell lung cancer (NSCLC) and an era of precision oncology. This text highlights the most clinically relevant oncogenic drivers other than EGFR, their management and current advancements in treatment. It also examines the different challenges in resistance to targeted therapies and diagnostic dilemmas for each oncogenic driver and the future direction of NSCLC management.

Lungs --- Cancer --- Treatment. --- Molecular aspects.

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"This book delves into several topics related to photosynthesis. It is the diversity of topics that makes this book special. The authors have also included the latest developments in the field. The book contains chapters from diverse areas such as a broad and inclusive definition of the "photosynthesis" including latest trends in the field i.e. artificial photosynthesis in Chapter One. The diversity of topics serves to generate inquisitiveness in the reader e.g. there are three chapters on stress (drought, light and nitric oxide) that will guide a UG/PG student into reading about more stresses e.g. salt, pesticides, heat, oxidant, toxic gases etc. and compare the molecular mechanisms of them. Furthermore, we have included chapters on the effect of various modifiers of CHL biosynthesis, nanomaterials, omics and senescence and the use of technology to enhance photosynthesis. The book is in sync with the UN- Sustainable Developmental Goals"--

Photosynthesis --- Plants --- Research. --- Molecular aspects. --- Effect of stress on

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Cancer - Genetic aspects. --- Cancer - Molecular aspects. --- Cancer cells. --- Cancer --- Genetic aspects. --- Molecular aspects. --- Cellules cancéreuses --- Aspect moléculaire --- Aspect génétique

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This, our third book on the Biochemistry and Cell Biology of Ageing in the Subcellular Biochemistry series, expands on the content of Part I, by covering additional biomedical topics. The 16 chapters included here, contributed by international knowledgeable scientists, review these further interesting topics at an advanced level. Following an Introductory chapter, these topics are included: Chromatin Structure from Development to Ageing, the Nuclear Envelope in Ageing and Progeria, Mitochondrial DNA Mutations and Ageing, the Proteasome and Ageing, Gap Junctions and Ageing, Cellular Senescence and Ageing, Therapeutic Opportunities Presented by Modulation of Cellular Senescence, Ageing at Molecular Level: Role of MicroRNAs, CircRNA and Ageing, Extracellular Vesicles and Cellular Ageing,Fibrinogen, Coagulation and Ageing, An Insight into Platelets at Older Age: Cellular and Clinical Perspectives, Ageing Skeletal Muscle: The Ubiquitous Muscle Stem Cell, Age-related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and its Potential effects on the Regulation of Lifespan, and Systems Biology of Ageing. The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers and academics in the field of Ageing. A further companion volume of the series (Part IV) covering the more Clinical Science aspects will be published soon. The seemingly endless expansion of ageing research continues to throw up important areas, that may well be covered in future volumes, together with updates of rapidly moving subjects. Thus, a further book on Anti-ageing Interventions (Part V) is under production.

Aging --- Clinical biochemistry. --- Molecular aspects. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Molecular aging --- Molecular biology

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These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.

Virology. --- Medicine—Research. --- Biology—Research. --- Biomedical Research. --- Microbiology --- Arboviruses --- History. --- Molecular aspects. --- Pathogenesis. --- Research.