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In this Special Issue, we present the state of the art in the field of pig genetics and genomics, including the identification of gene candidates linked to important pig traits and to nutritional modifications, with the aim of collecting the most recent advances. The published manuscripts focused on high-throughput methodologies, such as RNA sequencing, ATAC-seq, MACE-seq, chip-seq, and RRBS, and covered other fields of pig genetics. The pig (Sus scrofa) is the most common large mammal in the world. The Sus genus includes domestic pig and wild boar. Since the draft reference genome sequence of S. scrofa was assembled in 2012, the processes of identification of genes related to important phenotypic traits and of search of genetic markers for pig selection have been significantly refined. In addition, the newest wide-range high-throughput techniques, including microarrays, next-generation sequencing, and the recent PacBio sequencing platform providing ultra-long sequencing reads, allow identifying gene mutations and gene candidates throughout the whole genome, transcriptome, or epigenome and estimating quantitative traits important for breeding as well as the genetic backgrounds of inherited diseases.
Research & information: general --- Biology, life sciences --- Zoology & animal sciences --- HMOX1 gene --- promoter --- transcriptional regulation --- Hezuo Tibetan pig --- AQP3 --- pig --- intramuscular fat --- adipogenesis --- proliferation --- litter size --- total number born alive --- SNP (single nucleotide polymorphism) --- GWAS (Genome-Wide Association Studies) --- heat stress --- Duroc --- RNA-Seq --- NMR --- metabolome --- fatness --- obesity --- extracellular matrix --- fat deposition --- lipid metabolism --- NGS --- genetically modified pigs --- genome modifications --- transgenic pigs --- genetic engineering --- disease models --- recombinant proteins --- xenotransplantation --- xenoantigen --- coagulation system dysregulation --- CRISPR/Cas9 system --- non-homologous DNA ends joining (NHEJ) --- TIDE analysis --- off-target --- skeletal muscle fiber --- meat quality --- metabolic diseases --- lncRNA --- RNA-seq --- porcine β-defensin 2 --- CRISPR/Cas9 --- antimicrobial peptide --- disease-resistant animals --- porcine alveolar macrophages --- DNMT3B --- DNA methylation --- isoform --- TNF-α --- pigs --- fatty acids --- 3′quant mRNA-seq --- nutrigenomics --- TRIM26 --- antiviral response --- IFN-β --- poly (I:C) --- VSV --- PRRSV --- seminal plasma --- endometrium --- global gene expression --- microarray --- alternative splicing --- transcript --- protein --- domain --- single nucleotide polymorphism --- hypothalamus --- puberty --- circRNAs --- pubertal genes --- Duroc pigs --- growth traits --- weighted single-step GWAS --- SNP --- gene expression --- congenital defects --- transcriptomics --- swine --- Sus scrofa --- precision medicine --- lymphatic system --- whole-genome sequencing --- SNP array genotyping --- n/a --- 3'quant mRNA-seq
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A kaleidoscopic history of a world city over two eventful decadesWaterloo Sunrise is a panoramic and multifaceted account of modern London during the transformative years of the sixties and seventies, when a city still bearing the scars of war emerged as a vibrant yet divided metropolis. John Davis paints lively and colorful portraits of life in the British capital, covering topics as varied as the rise and fall of boutique fashion, Soho and the sex trade, eating out in London, cabbies and tourists, gentrification, conservation, suburbia and the welfare state.With vivid and immersive scene-setting, Davis traces how ‘swinging London’ captured the world’s attention in the mid-sixties, discarding postwar austerity as it built a global reputation for youthful confidence and innovative music and fashion. He charts the slow erosion of mid-sixties optimism, showing how a newly prosperous city grappled with problems of deindustrialisation, inner-city blight and racial friction. Davis reveals how London underwent a complex evolution that reflected an underlying tension between majority affluence and minority deprivation. He argues that the London that had taken shape by the time of Margaret Thatcher’s election as prime minister in 1979 already displayed many of the features that would come to be associated with ‘Thatcher’s Britain’ of the eighties.Monumental in scope, Waterloo Sunrise draws on a wealth of archival evidence to provide an evocative, engrossing account of Britain’s ever-evolving capital city.
London (England) --- History --- Social change --- Nineteen sixties. --- Nineteen seventies. --- 1970s --- 70s (Twentieth century decade) --- Seventies (Twentieth century decade) --- Twentieth century --- 1960s --- 60s (Twentieth century decade) --- Sixties (Twentieth century decade) --- Change, Social --- Cultural change --- Cultural transformation --- Societal change --- Socio-cultural change --- Social history --- Social evolution --- Activism. --- Advertising. --- Annual report. --- Authoritarianism. --- Battersea North (UK Parliament constituency). --- Behavior. --- Boosterism. --- Boutique. --- Brigitte Bardot. --- Canonbury. --- Carnaby Street (radio programme). --- Carnaby Street. --- Central London. --- Cess. --- Chairman. --- Clothing. --- Community development. --- Community politics. --- Competition. --- Correspondent. --- Council house. --- Councillor. --- Customer. --- Deckchair. --- Deindustrialization. --- Designer. --- Employment. --- Eviction. --- Feminism (international relations). --- Figurehead. --- Gentrification. --- Greater London Council. --- Greater London. --- Harrods. --- Headstone Manor. --- Homelessness. --- Hostel. --- Immigration. --- Income. --- Indication (medicine). --- Individualism. --- Inner London. --- John Stephen. --- Journalism. --- Kings Cross, London. --- Labour council. --- Leeds Permanent Building Society. --- Legislation. --- Local government. --- London boroughs. --- Mary Quant. --- Meal. --- Minority group. --- North Sea oil. --- Notting Hill. --- Patrick Geddes. --- Permanent revolution. --- Politics. --- Port of London Authority. --- Post-industrial society. --- Predictability. --- Prosecutor. --- Public housing in the United Kingdom. --- Public housing. --- Public inquiry. --- Racism. --- Real estate economics. --- Red tape. --- Red wine. --- Redevelopment. --- Renovation. --- Restaurant. --- Retail. --- Romford. --- Ronan Point. --- Royal Town Planning Institute. --- Shortage. --- Simon Jenkins. --- Slum. --- Social Security System (Philippines). --- South London Press. --- Spaghetti alle vongole. --- Strip club. --- Structure plan. --- Student protest. --- Suburb. --- Suede. --- Suggestion. --- Swinging (sexual practice). --- Swinging London. --- Thatcherism. --- Tourism. --- Trafalgar Square. --- Trattoria. --- Unemployment. --- Unilever. --- Urban planning. --- Wealth. --- Welfare state. --- White paper.
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