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"Neuroplasticity: From Bench to Bedside, Volume 184 in the Handbook of Clinical Neurology series, provides a comprehensive multidisciplinary guide to neuroplasticity. Sections summarize the basic mechanisms of neuroplasticity, focus on neuroplasticity in movement disorders, discuss brain oscillations in neurological disorders, segue into plasticity in neurorehabilitation, and cover issues of inflammation and autoimmunity in neuroplasticity. The book concludes with a section on neuroplasticity and psychiatric disorders"--

Neuroplasticity. --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Adaptation (Physiology) --- Neurophysiology --- Developmental neurobiology --- Neuronal Plasticity

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Synaptic plasticity, defined as the modification of synaptic strength, plays a very important role in
many mechanisms such as memory or learning. There are several types of synaptic plasticity, the best known and most studied being homosynaptic plasticity where a synapse strength is modified by its own activity. However, this type of plasticity cannot explain all phenomena and other types of plasticity are needed. Heterosynaptic plasticity is defined as changes in the synaptic strength induced by the activity of adjacent synapses. Until now, only scarce data, either experimental or computational, have been generated to study heterosynaptic plasticity. Yet, this type of plasticity is necessary, especially to study pain-related phenomena.
Pain may be triggered by various causes. Moreover, following an injury, one can notice an increase in sensitivity to touch on and around the wound. Thus, a caress, no matter how gentle, will cause a sensation of pain. This phenomenon is known as allodynia. Studies have shown that central sensitization, an increase in the excitation of synapses in the spinal cord, has a role to play in the induction of allodynia. Both homosynaptic and heterosynaptic plasticities are involved.
The aim of this thesis is to establish a new model of heterosynaptic plasticity with the subsidiary
goal of modeling allodynia. To do so, we started with two homosynaptic plasticity models (calcium-based and pair-based spike-timing dependent plasticity (STDP)) to which we added a heterosynaptic dimension by modeling two presynaptic neurons and one postsynaptic neuron. In the calcium-based model, this has been done through the integration of a new parameter α, intervening when presynaptic neurons spike, which could represent the distance between two presynaptic neurons or the amount of calcium diffusing (or being released) through the postsynaptic neuron. In the pair-based model, this has been done through the integration of two new parameters α, governing the potentiation, and Ahet governing the depression of synaptic weights. Both parameters intervene when the presynaptic neurons spike. We studied the dependency between α and Ahet which shows that when they are independent of each other, a phenomenon of pruning, the mechanism by which some neuronal connections are eliminated after some time, can be inferred with the right set of parameters. Our new calcium-based heterosynaptic models were evaluated in the same experimental conditions previously
reported by Chistiakova et al. and we were able to reproduce a Mexican hat pattern where the
induction of homosynaptic long-term potentiation (LTP) provokes weaker LTP at the closest neighbor
synapses, long-term depression (LTD) at further neighbor synapses and no modification at the furthest neighbor synapses. Finally, we were able to customize our new models to reproduce a mechanism of heterosynaptic central sensitization causing allodynia. However, our models have shown a certain fragility that may be related to suboptimal physiological modeling.
In conclusion, our new models introduced for the first time two new parameters namely α and Ahet which, in our view, could contribute to better model heterosynaptic plasticity. However, further work will be needed to flesh out our models in the future.

Heterosynaptic plasticity --- Allodynia --- Biological neuron model --- synaptic plasticity --- Ingénierie, informatique & technologie > Multidisciplinaire, généralités & autres

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Neural plasticity--the brain's ability to change in response to normal developmental processes, experience, and injury--is a critically important phenomenon for both neuroscience and psychology. This book is a unique contribution to research and to the literature on clinical neuroscience.

Developmental neurophysiology. --- Neuroplasticity. --- Cerebral cortex. --- Developmental neurobiology --- Neurophysiology --- Brain mantle --- Cortex, Cerebral --- Cortex cerebri --- Mantle of brain --- Pallium (Brain) --- Telencephalon --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Adaptation (Physiology)

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"Handbook of Rheological Additives covers how these additives are commonly applied in a wide range of industries, providing readers with information on over 300 organic and inorganic additives. [...] Discusses the various applications of rheological additives, polymer processing methods that require rheological agents, and health, safety, and environmental considerations in their use."--

Rheology. --- Colloids --- Deformations (Mechanics) --- Elasticity --- Plasticity --- Viscosity --- Rheology --- Organic compounds --- Inorganic compounds --- Additives

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Plastics production comprises the main process steps "synthesis (reaction)", "preparation/compounding" at the raw material manufacturer and compounder, and "processing" (shaping into semi-finished or finished products). In this handbook, the central middle step, preparation and compounding, is discussed. The preparation tasks include the removal of components, the incorporation of additives, and the change of particle size. Compounding is the incorporation of additives into a polymer or plastic. The process engineering fundamentals and the specific equipment and machines used are described. The specialist authors impart their knowledge from the fields of research, polymer production, and equipment/machine production with applications in plastics technology.

Plastics --- Mixing --- Plastic materials --- Plastic products --- Polymers --- Synthetic products --- Condensation products (Chemistry) --- Elastomers --- Plasticity --- Polymerization