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2022 (4)

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Book
Strategies to Improve Antineoplastic Activity of Drugs in Cancer Progression
Author:
ISBN: 3036559272 3036559280 Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies.

Keywords

Research & information: general --- Biology, life sciences --- EGR-1 --- flavonoid --- (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile --- MDA-MB-231 --- MMP9 --- TNFα --- pancreatic ductal adenocarcinoma --- cyclodextrin inclusion complex --- phase solubility studies --- preformulation studies --- biphenylnicotinamide derivatives --- dual inhibitor --- EGFR --- VEGFR2 --- ligand-based pharmacophore --- molecular docking --- molecular dynamics --- leukemias --- doxorubicin --- inflammation --- drug delivery --- tumor targeting --- elastin-like polypeptide --- cell penetrating peptide --- matrix metalloproteinase --- doxorubicin resistance --- photosensitizer delivery system --- PAMAM dendrimer --- photodynamic therapy --- cytotoxicity --- phototoxicity --- colorectal adenocarcinoma --- dicarboximides --- chemical synthesis --- apoptosis --- kinases --- anticancer --- gene profiling --- SAR --- biomarkers --- colorectal cancer --- early detection examination --- liquid biopsy --- personalized medicine --- tumor treatment --- exosomes --- ctDNA --- CTC --- cytotoxic activity --- pyrazole derivatives --- MTT assay --- ADMET analysis --- single-crystal diffraction --- FTIR spectroscopy --- NMR spectroscopy thermogravimetric analysis --- acute myelogenous leukemia --- platelets --- microparticles --- γδ T cells --- immunotherapy --- tumor resistance --- combination therapy --- tumor microenvironment --- immune checkpoint inhibitor --- neuroblastoma --- molecular iodine --- cyclophosphamide --- xenografts --- metronomic therapy --- tamoxifen --- CYP2D6 --- MCF-7 --- Ishikawa cells --- SERM --- TNBC --- uterotrophic --- α-mangostin --- poly(amidoamine) dendrimer --- targeted drug delivery --- biotin targeting --- glioblastoma multiforme --- squamous cell carcinoma --- antiparasitic therapy --- diclofenac --- indomethacin --- oleanolic acid derivative conjugates --- NF-κB --- Nrf2 --- MAPKs --- PSN-1 cells --- reactive oxygen species --- glioblastoma --- brain tumor --- extracellular vesicles --- pancreatic cancer --- paclitaxel --- clathrin --- endocytosis --- sulforaphane --- nicotine --- metalloproteinase-9 --- gastric cancer --- cell invasion --- Arylquin 1 --- colon cancer --- tumor progression --- azelastine --- oxidative stress --- autophagy --- mitotic catastrophe --- chronic myeloid leukemia --- imatinib --- tyrosine kinase --- ketoconazole --- P-glycoprotein --- drug efflux transporter --- non-small-cell lung cancer --- cisplatin resistance --- aldehyde dehydrogenase --- isothiocyanates --- disulfiram --- epithelial to mesenchymal transition --- aminopeptidase N --- acetamidophenones --- Schiff bases --- semicarbazones --- thiosemicarbazones --- inhibition of proliferation


Book
Celebrating 120 Years of Butantan Institute Contributions for Toxinology
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This is collection of original and review articles selected in recognition of the contribution of Instituto Butantan to the field of toxinology and its continued and relevant role in this field in the 120 years since its foundation. Congratulations to the Butantan Institute, its house scientists, and collaborators on its 120th anniversary!

Keywords

Research & information: general --- Biology, life sciences --- mass spectrometry --- proteome --- snake venom --- Bothrops jararaca --- breast cancer --- HF3 --- human plasma --- proteolysis --- snake venom metalloproteinase --- Bothrops atrox --- blister --- local damage --- DAMPs --- antivenom --- snakebite --- Bothrops --- metalloproteases --- inflammation --- microcirculation --- adhesion molecules --- leukocyte-endothelium interactions --- individual variability --- venom heterogeneity --- STEC --- Stx2 --- antibody fragment --- monoclonal antibody --- neurodegenerative disease --- neurodegeneration --- IL-17 --- glial cells --- crotoxin --- epithelial-mesenchymal transition --- spheroid model --- tumor stroma --- Lonomia --- envenoming --- innovation --- Tityus serrulatus --- venom components --- hypotensins --- NEP inhibition --- cytokines --- toxins --- venoms --- skin secretion --- drug discovery --- scorpion accidents --- lactation --- maternal care --- seizure threshold --- leech --- Haementeria vizottoi --- cysteine proteases inhibitor --- recombinant cystatin --- cathepsin L --- Cryptops iheringi --- centipede --- venom --- toxin --- transcriptome --- recombinant protein --- venomics --- chilopoda --- oral tolerance --- ELISA --- Bothrops phospholipases A2 --- lipid mediators --- signaling pathways --- fish venoms --- cytolysins --- multifunctionality --- pore formation --- Bitis arietans venom (BaV) --- Kn-Ba --- cytokines and chemokines --- PGE2 --- THP-1 macrophages --- analgesic peptide --- protein kinase C --- hyperalgesia --- cell-signaling --- Hyalomma dromedarii --- salivary glands --- serpin --- anticoagulants --- thrombin inhibitor --- β-defensins --- snakes --- antimicrobial activity --- bioisosterism --- peptides --- Thalassophryne --- nattectin --- reverse-phase HPLC --- MALDI-ToF --- hemagglutinating activity --- antibacterial activity --- toxinology --- animal toxins --- mass spectrometry --- proteome --- snake venom --- Bothrops jararaca --- breast cancer --- HF3 --- human plasma --- proteolysis --- snake venom metalloproteinase --- Bothrops atrox --- blister --- local damage --- DAMPs --- antivenom --- snakebite --- Bothrops --- metalloproteases --- inflammation --- microcirculation --- adhesion molecules --- leukocyte-endothelium interactions --- individual variability --- venom heterogeneity --- STEC --- Stx2 --- antibody fragment --- monoclonal antibody --- neurodegenerative disease --- neurodegeneration --- IL-17 --- glial cells --- crotoxin --- epithelial-mesenchymal transition --- spheroid model --- tumor stroma --- Lonomia --- envenoming --- innovation --- Tityus serrulatus --- venom components --- hypotensins --- NEP inhibition --- cytokines --- toxins --- venoms --- skin secretion --- drug discovery --- scorpion accidents --- lactation --- maternal care --- seizure threshold --- leech --- Haementeria vizottoi --- cysteine proteases inhibitor --- recombinant cystatin --- cathepsin L --- Cryptops iheringi --- centipede --- venom --- toxin --- transcriptome --- recombinant protein --- venomics --- chilopoda --- oral tolerance --- ELISA --- Bothrops phospholipases A2 --- lipid mediators --- signaling pathways --- fish venoms --- cytolysins --- multifunctionality --- pore formation --- Bitis arietans venom (BaV) --- Kn-Ba --- cytokines and chemokines --- PGE2 --- THP-1 macrophages --- analgesic peptide --- protein kinase C --- hyperalgesia --- cell-signaling --- Hyalomma dromedarii --- salivary glands --- serpin --- anticoagulants --- thrombin inhibitor --- β-defensins --- snakes --- antimicrobial activity --- bioisosterism --- peptides --- Thalassophryne --- nattectin --- reverse-phase HPLC --- MALDI-ToF --- hemagglutinating activity --- antibacterial activity --- toxinology --- animal toxins


Book
Natural and Synthetic Bioactives for Skin Health, Disease and Management
Authors: --- ---
ISBN: 3036560688 303656067X Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

In recent years, researchers have shown a special interest in natural products as alternative methods for the prevention, treatment, and/or management of various skin illnesses and disorders, primarily due to their natural availability, efficacity, reduced cost, and minimal toxicity. In a similar vein, synthetic bioactives, as well as small molecules, have been studied in vitro, in vivo, and in clinical studies as potential drugs or supplements. This Special Issue of Nutrients comprises an array of literature reviews, original communications, and studies on the roles of natural products, synthetic bioactives, and small molecules in a variety of skin disorders and diseases, such as aging, atopic dermatitis, cutaneous T-cell lymphomas, melanoma, allergies, hyperpigmentation, inflammation, and more, which were investigated through in vitro and ex vivo approaches, preclinical trials, cell-based assays, and animal models. The mechanisms of action of certain compounds are proposed, while others are currently under investigation. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of skin disorders, the wealth of information published in this Special Issue can act as a springboard for the development of new preventive and therapeutic modalities for the management of skin diseases.

Keywords

Research & information: general --- Biology, life sciences --- keratinocytes --- rutin --- ascorbic acid --- UV radiation --- proteomics --- 3D cell culture --- borage oil --- triacylglycerol metabolism --- acyl-ceramide --- corneocyte lipid envelope --- epidermis --- anti-melanogenesis --- B16/F10 melanoma cell --- hydroxyoctadecadienoic acid --- Sorghum bicolor --- 3-isobutyl-1-methylxanthine --- mycosis fungoides --- atopic dermatitis --- cutaneous lymphomas --- cornified envelope proteins --- FLG --- microalgae --- Planktochlorella nurekis --- skin cells --- proliferation --- senescence --- holothuroids --- glycosaminoglycans --- inflammation --- ear-inflammation --- whey --- Lactobacillus helveticus --- melanin --- α-melanocyte-stimulating hormone --- tyrosinase --- tyrosinase-related protein 1 --- dopachrome tautomerase --- microphthalmia-associated transcription factor --- cosmetics --- black cumin --- Nigella sativa --- Thymocid® --- skin aging --- glycation --- collagen --- collagenase --- elastase --- melanogenesis --- cosmeceutical --- konjac glucomannan --- ultraviolet B --- human epidermal primary melanocytes --- human embryonic fibroblasts --- anti-inflammatory activity --- antioxidant activity --- Cornus officinalis --- molecular docking --- human high-affinity IgE receptors --- α-MSH --- UVB irradiation --- lotus seedpod extract --- epigallocatechin --- propolis --- skin --- matrix metalloproteinase-1 --- UV --- phosphoinositide 3-kinase --- skin care --- skin health --- bioactive substances --- phytonutrients --- antioxidants --- nutraceuticals --- Perilla frutescens --- cell proliferation --- ultraviolet radiation --- DNA repair --- Lactobacillus plantarum CJLP55 --- acne vulgaris --- sebum --- hydration --- urine bacterial extracellular vesicles --- fungal infections --- nanohydrogel --- polysaccharide --- essential oils --- eggshell membrane --- keratinocyte differentiation --- TRPV --- skin thickness --- Lithospermum erythrorhizon --- NC/Nga --- Th1 --- Th2 --- Th17 --- Th22 --- immune balance --- skin barrier function --- n/a


Book
Celebrating 120 Years of Butantan Institute Contributions for Toxinology
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

This is collection of original and review articles selected in recognition of the contribution of Instituto Butantan to the field of toxinology and its continued and relevant role in this field in the 120 years since its foundation. Congratulations to the Butantan Institute, its house scientists, and collaborators on its 120th anniversary!

Keywords

mass spectrometry --- proteome --- snake venom --- Bothrops jararaca --- breast cancer --- HF3 --- human plasma --- proteolysis --- snake venom metalloproteinase --- Bothrops atrox --- blister --- local damage --- DAMPs --- antivenom --- snakebite --- Bothrops --- metalloproteases --- inflammation --- microcirculation --- adhesion molecules --- leukocyte-endothelium interactions --- individual variability --- venom heterogeneity --- STEC --- Stx2 --- antibody fragment --- monoclonal antibody --- neurodegenerative disease --- neurodegeneration --- IL-17 --- glial cells --- crotoxin --- epithelial–mesenchymal transition --- spheroid model --- tumor stroma --- Lonomia --- envenoming --- innovation --- Tityus serrulatus --- venom components --- hypotensins --- NEP inhibition --- cytokines --- toxins --- venoms --- skin secretion --- drug discovery --- scorpion accidents --- lactation --- maternal care --- seizure threshold --- leech --- Haementeria vizottoi --- cysteine proteases inhibitor --- recombinant cystatin --- cathepsin L --- Cryptops iheringi --- centipede --- venom --- toxin --- transcriptome --- recombinant protein --- venomics --- chilopoda --- oral tolerance --- ELISA --- Bothrops phospholipases A2 --- lipid mediators --- signaling pathways --- fish venoms --- cytolysins --- multifunctionality --- pore formation --- Bitis arietans venom (BaV) --- Kn-Ba --- cytokines and chemokines --- PGE2 --- THP-1 macrophages --- analgesic peptide --- protein kinase C --- hyperalgesia --- cell-signaling --- Hyalomma dromedarii --- salivary glands --- serpin --- anticoagulants --- thrombin inhibitor --- β-defensins --- snakes --- antimicrobial activity --- bioisosterism --- peptides --- Thalassophryne --- nattectin --- reverse-phase HPLC --- MALDI-ToF --- hemagglutinating activity --- antibacterial activity --- toxinology --- animal toxins --- n/a --- epithelial-mesenchymal transition

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