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Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.
Technology: general issues --- Biotechnology --- biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine --- biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine
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Developing new materials is usually a time-demanding and meticulous process, but at the same time, it is one of the more promising solutions to obtain a cleaner, safer, and smart future. More in detail, referring to nanomaterials, an increasingly successfully tool of nanotechnologies, nanoparticles are categorized as materials in which at least one dimension is less than 100 nm in diameter. Among the various nanoparticles’ categories, metal and metal oxides nanoparticles stand as an emerging nanotechnological solution for a wide range of biological and medical physio/pathological open questions. This Special Issue covers the fundamental science, design, characterization, and biomedical applications of metal and metal oxide nanomaterials. The articles here presented will embrace all the aspects determining the performance of these systems, ranging from their synthesis, design, chemical, physical, and biological functionalization, to their characterization and successful applications.
Technology: general issues --- mesoporous zinc oxide --- polyHEMA --- hydrogel --- drug-eluting stent --- pH-triggered drug release --- self-assembly --- nanoshells (hollow spheres) --- janus particles --- pickering emulsion --- bismuth oxide --- nanoparticles --- radiopacity --- chemotherapy --- theragnostic --- metal nanoparticles --- iron oxide nanoparticles --- silver nanoparticles --- gold nanoparticles --- titanium dioxide nanoparticles --- zinc nanoparticles --- reactive oxygen species --- photodynamic therapy --- photothermal therapy --- sonodynamic therapy --- magnetite nanoparticles --- magnetic nanoparticles --- immobilization --- protein --- polymer coating --- n/a
Choose an application
Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.
Technology: general issues --- Biotechnology --- biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine
Choose an application
Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.
biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine
Choose an application
Developing new materials is usually a time-demanding and meticulous process, but at the same time, it is one of the more promising solutions to obtain a cleaner, safer, and smart future. More in detail, referring to nanomaterials, an increasingly successfully tool of nanotechnologies, nanoparticles are categorized as materials in which at least one dimension is less than 100 nm in diameter. Among the various nanoparticles’ categories, metal and metal oxides nanoparticles stand as an emerging nanotechnological solution for a wide range of biological and medical physio/pathological open questions. This Special Issue covers the fundamental science, design, characterization, and biomedical applications of metal and metal oxide nanomaterials. The articles here presented will embrace all the aspects determining the performance of these systems, ranging from their synthesis, design, chemical, physical, and biological functionalization, to their characterization and successful applications.
mesoporous zinc oxide --- polyHEMA --- hydrogel --- drug-eluting stent --- pH-triggered drug release --- self-assembly --- nanoshells (hollow spheres) --- janus particles --- pickering emulsion --- bismuth oxide --- nanoparticles --- radiopacity --- chemotherapy --- theragnostic --- metal nanoparticles --- iron oxide nanoparticles --- silver nanoparticles --- gold nanoparticles --- titanium dioxide nanoparticles --- zinc nanoparticles --- reactive oxygen species --- photodynamic therapy --- photothermal therapy --- sonodynamic therapy --- magnetite nanoparticles --- magnetic nanoparticles --- immobilization --- protein --- polymer coating --- n/a
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Hydrogels are a class of soft materials with crosslinked network structures. They show good biocompatibility, biodegradability, hydrophilicity, and mechanical properties similar to those of tissue, so they have a wide range of applications. In recent years, a variety of multifunctional hydrogels with excellent performance have been developed, greatly expanding the depth and breadth of their applications. This book is the reprint of the Special Issue “Advances in Hydrogels”, which focused on the recent advances regarding hydrogels, aiming to provide reference for researchers in related fields. This book included one editorial, thirteen original research articles, and three valuable reviews from thirteen different countries including Canada, China, Thailand, Mexico, India, Saudi Arabia, Chile, Germany, the Czech Republic, Colombia, Romania, Israel, and the USA.
Research & information: general --- Physics --- molecularly imprinted polymeric hydrogels --- synthetic receptors --- zearalenone --- glucuronic acid --- fluorescent sensors --- PEG-PLA --- thermoresponsive hydrogel --- redox-sensitive --- hydrogel --- superabsorbent --- e-beam --- swelling --- crosslinking --- carboxymethyl cellulose --- drying --- RW --- CHD --- radiation penetration depth --- lecithin --- rheology --- scanning electron microscopy --- drying and swelling --- extracellular matrix --- mesh size --- hydrogels --- photopolymers --- volume holography --- photo curing --- multifunctional biomedical biomaterials --- light-responsive materials --- novel formulations --- natural polymer --- synthetic polymer --- topical application --- cryoconcentrated blueberry juice --- stability --- storage --- bioactive compounds content --- antioxidant activity --- water gel --- photocrosslinking --- natural polymer modification --- biomedical-engineering applications --- vitamin D --- nanoemulsion --- gelled matrices --- texture analysis --- gelatin --- sensory evaluation --- gummy --- thermosensitive --- P(OEGMA-co-MEO2MA) --- microgel --- scaffold --- 3D culture --- commercial copper sulfide (CuS) --- alginate --- photothermal therapy (PTT) --- near-infrared II windows --- cancer --- glioblastoma --- mechanobiology --- mechanoreceptor --- mechanotransduction --- quercetin --- cyclodextrin --- polyvinyl alcohol --- inclusion complex --- photo-polymerization --- potassium acrylate-co-acrylamide --- swelling capacity --- multistructured --- adhesive strength --- hydrogen bonding --- n/a
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New approaches to deal with the growing concern associated with antibiotic-resistant bacteria are in great demand. For many years, antibiotics have widely been employed to treat infections. However, their excessive consumption and misuse have accelerated the rise of antibiotic-resistant microorganisms, which constitute a major challenge to global health. The antibiotic crisis is now a general concern; therefore, alternative biomolecules or drug delivery systems to treat infections are urgently needed. From natural extracts to traditional medicine remedies, to newly engineered nanocapsules and nanoparticles, to bio-based, biodegradable delivery platforms, many systems to fight infections are explored in this book.
nanoparticles --- 4-Nerolidylcatechol --- antifungals --- Microsporum canis --- polycaprolactone --- nanoprecipitation --- silver nanoparticles --- green synthesis method --- Catharanthus roseus --- Azadirachta indica --- multidrug-resistant bacteria --- wound healing --- nosocomial infection --- plant extract --- grapefruit seed extract --- antibacterial activity --- fiber–hydrogel composite --- biodegradable polymers --- skin regeneration --- drug delivery platforms --- controlled release --- tetramycin --- antimicrobial activity --- kiwifruit disease --- conventional antibiotics --- storage quality --- gold nanoparticles --- flavonoids --- Gram-negative bacteria --- DNA gyrase --- in silico --- multidrug-resistant Acinetobacter baumannii (MDR-AB) --- hypertonic saline --- antibiotics --- biofilm --- aerosol delivery --- ultrahigh-throughput screening --- live biosensors --- antibiotic discovery --- gram-negative pathogens --- microfluidic droplet cocultivation --- efficient promoters --- polymyxins --- colistin biosynthetic gene cluster --- single cell --- multi-omics --- quercetin --- magnesium-doped calcium silicate --- osteogenic activity --- bone regeneration and nanofiber scaffold --- bulk-tank milk --- mastitis --- methicillin --- milk --- goat --- somatic cell counts --- staphylococcus --- tetracycline --- total bacterial counts --- prosthetic joint infection --- local prevention --- allicin --- chitosan --- Sphaerotheca sp. --- antibiotic --- Rosa roxburghii --- cyclic diphenylphosphonate --- quinoline --- DNA gyrase inhibitor --- molecular docking --- magnesium ion --- n/a --- fiber-hydrogel composite
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This book highlights novel nano-engineering advances that enable enhanced bone formation at the implant/biomaterial and bone tissue interface, towards bone tissue engineering applications. Spanning a variety of biomaterial categories, from nanofibrous scaffolds (natural and synthetic) to the nanoscale modification of metallic implants, novel bioactive and therapeutic modifications have made it possible to enhance new bone formation, which could be particularly useful for the management of compromised sites.
Technology: general issues --- History of engineering & technology --- human tooth powder --- bioceramics --- biocompatibility --- bone regeneration --- vascularization --- nano-composite --- microstructure --- nanoindentation --- bone implants --- powder metallurgy --- calcium orthophosphates --- nano-hydroxyapatite --- eggshell --- cuttlefish bone --- mussel shell --- amorphous calcium carbonate --- hydrogel --- tissue engineering --- biphasic calcium phosphate nanoparticle (BCP-NP) --- biodegradable --- gelatin methacryloyl (GelMA) --- visible light --- inorganic nanomaterials --- nano hydroxyapatites --- nano silica --- metallic nanomaterials --- magnesium and its alloys --- hydroxyapatite --- surface modifications --- titanium implants --- corrosion analysis --- bioactivity --- biomaterial --- bone substitute --- apatite --- microwave-assisted hydrothermal synthesis --- microgeometry --- mechanobiology --- global DNA methylation --- osteoblast mechanosensing --- human tooth powder --- bioceramics --- biocompatibility --- bone regeneration --- vascularization --- nano-composite --- microstructure --- nanoindentation --- bone implants --- powder metallurgy --- calcium orthophosphates --- nano-hydroxyapatite --- eggshell --- cuttlefish bone --- mussel shell --- amorphous calcium carbonate --- hydrogel --- tissue engineering --- biphasic calcium phosphate nanoparticle (BCP-NP) --- biodegradable --- gelatin methacryloyl (GelMA) --- visible light --- inorganic nanomaterials --- nano hydroxyapatites --- nano silica --- metallic nanomaterials --- magnesium and its alloys --- hydroxyapatite --- surface modifications --- titanium implants --- corrosion analysis --- bioactivity --- biomaterial --- bone substitute --- apatite --- microwave-assisted hydrothermal synthesis --- microgeometry --- mechanobiology --- global DNA methylation --- osteoblast mechanosensing
Choose an application
Developing new materials is usually a time-demanding and meticulous process, but at the same time, it is one of the more promising solutions to obtain a cleaner, safer, and smart future. More in detail, referring to nanomaterials, an increasingly successfully tool of nanotechnologies, nanoparticles are categorized as materials in which at least one dimension is less than 100 nm in diameter. Among the various nanoparticles’ categories, metal and metal oxides nanoparticles stand as an emerging nanotechnological solution for a wide range of biological and medical physio/pathological open questions. This Special Issue covers the fundamental science, design, characterization, and biomedical applications of metal and metal oxide nanomaterials. The articles here presented will embrace all the aspects determining the performance of these systems, ranging from their synthesis, design, chemical, physical, and biological functionalization, to their characterization and successful applications.
Technology: general issues --- mesoporous zinc oxide --- polyHEMA --- hydrogel --- drug-eluting stent --- pH-triggered drug release --- self-assembly --- nanoshells (hollow spheres) --- janus particles --- pickering emulsion --- bismuth oxide --- nanoparticles --- radiopacity --- chemotherapy --- theragnostic --- metal nanoparticles --- iron oxide nanoparticles --- silver nanoparticles --- gold nanoparticles --- titanium dioxide nanoparticles --- zinc nanoparticles --- reactive oxygen species --- photodynamic therapy --- photothermal therapy --- sonodynamic therapy --- magnetite nanoparticles --- magnetic nanoparticles --- immobilization --- protein --- polymer coating --- mesoporous zinc oxide --- polyHEMA --- hydrogel --- drug-eluting stent --- pH-triggered drug release --- self-assembly --- nanoshells (hollow spheres) --- janus particles --- pickering emulsion --- bismuth oxide --- nanoparticles --- radiopacity --- chemotherapy --- theragnostic --- metal nanoparticles --- iron oxide nanoparticles --- silver nanoparticles --- gold nanoparticles --- titanium dioxide nanoparticles --- zinc nanoparticles --- reactive oxygen species --- photodynamic therapy --- photothermal therapy --- sonodynamic therapy --- magnetite nanoparticles --- magnetic nanoparticles --- immobilization --- protein --- polymer coating
Choose an application
This book highlights novel nano-engineering advances that enable enhanced bone formation at the implant/biomaterial and bone tissue interface, towards bone tissue engineering applications. Spanning a variety of biomaterial categories, from nanofibrous scaffolds (natural and synthetic) to the nanoscale modification of metallic implants, novel bioactive and therapeutic modifications have made it possible to enhance new bone formation, which could be particularly useful for the management of compromised sites.
human tooth powder --- bioceramics --- biocompatibility --- bone regeneration --- vascularization --- nano-composite --- microstructure --- nanoindentation --- bone implants --- powder metallurgy --- calcium orthophosphates --- nano-hydroxyapatite --- eggshell --- cuttlefish bone --- mussel shell --- amorphous calcium carbonate --- hydrogel --- tissue engineering --- biphasic calcium phosphate nanoparticle (BCP-NP) --- biodegradable --- gelatin methacryloyl (GelMA) --- visible light --- inorganic nanomaterials --- nano hydroxyapatites --- nano silica --- metallic nanomaterials --- magnesium and its alloys --- hydroxyapatite --- surface modifications --- titanium implants --- corrosion analysis --- bioactivity --- biomaterial --- bone substitute --- apatite --- microwave-assisted hydrothermal synthesis --- microgeometry --- mechanobiology --- global DNA methylation --- osteoblast mechanosensing --- n/a
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