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Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI-Based Approach exposes readers to the various existing mathematical models that define the dynamics of glucose-insulin for Type 1 diabetes patients. After providing insights into the mathematical model of patients, the authors discuss the need and emergence of new control techniques that can lead to further development of an artificial pancreas. The book presents various nonlinear control techniques to address the challenges that Type 1 diabetic patients face in maintaining their blood glucose level in the safe range (70-180 mg/dl). The closed-loop solution provided by the artificial pancreas depends mainly on the effectiveness of the control algorithm, which acts as the brain of the system. APS control algorithms require a mathematical model of the gluco-regulatory system of the T1D patients for their design. Since the gluco-regulatory system is inherently nonlinear and largely affected by external disturbances and parametric uncertainty, developing an accurate model is very difficult.

Blood Glucose --- Pancreas, Artificial --- Glucose Metabolism Disorders --- Glucose Metabolic Disorder --- Glucose Metabolic Disorders --- Glucose Metabolism Disorder --- Disorder, Glucose Metabolic --- Disorder, Glucose Metabolism --- Disorders, Glucose Metabolic --- Disorders, Glucose Metabolism --- Metabolic Disorder, Glucose --- Metabolic Disorders, Glucose --- Metabolism Disorder, Glucose --- Metabolism Disorders, Glucose --- Artificial Pancreas --- Blood Sugar --- Glucose, Blood --- Sugar, Blood --- Glucose --- Glycemic Index --- blood --- Blood glucose monitoring --- Nonlinear control theory. --- Technological innovations. --- Control theory --- Nonlinear theories --- Blood glucose self-monitoring --- Blood sugar monitoring --- Monitoring, Blood glucose --- Blood glucose --- Patient monitoring --- Analysis --- Diabetes. --- Artificial pancreas. --- Diabetes Mellitus --- Models, Theoretical --- Mathematical models.

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Agir sur notre courbe glycémique est le geste le plus efficace que nous puissions faire pour notre santé. Près de 90% de la population souffre d'un dérèglement du glucose et la plupart l'ignore ! Les symptômes ? Fringales, fatigue, acné, vieillissement prématuré, infertilité... et, au fil du temps, des maladies inflammatoires comme le diabète de type 2, les cancers ou les problèmes cardiaques. S'appuyant sur 300 études scientifiques récentes et sur ses propres recherches, Jessie Inchauspé vous explique le rôle crucial du glucose dans votre organisme et propose 10 conseils simples et surprenants en matière d'alimentation et de mode de vie pour faire disparaître ces symptômes sans faire de régime ni renoncer aux aliments que vous aimez.

Blood Glucose. --- Glycemic Control. --- Sugars. --- Diabetes Mellitus --- Diet Therapy. --- Glucose sanguin. --- Glucides. --- Diétothérapie. --- Diabètes --- diet therapy. --- Diétothérapie.

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Insulin resistance is a key player in the pathology of cardiometabolic diseases - obesity, hypertension, dyslipidaemia, type 2 diabetes and NAFLD. These diseases are commonly associated with a peripheral insulin resistance, but an important role of insulin is played at brain circuitries that control food behaviour and autonomic activity. Brain insulin resistance is also associated with cognition impairment and Alzheimer Disease and other neurodegenerative diseases. Disruptions in diet composition, e.g. hypercaloric diets, and patterns, as well as nutritional status contribute to the genesis of insulin resistance. In contrast, hypocaloric diets, different feed regimens and some nutrients have beneficial impacts on insulin resistance and disease development. This special issue “Impact of diet composition on insulin resistance” is developed to compile studies that highlight the beneficial or deleterious impact of different nutritional plans on insulin sensitivity and metabolism and that unravel mechanistic links between diet composition and nutritional status and the development of insulin resistance, both periphery and centrally.

Research & information: general --- Biology, life sciences --- Food & society --- caffeine --- obstructive sleep apnea --- apnea/hipopnea index --- sleep architecture catecholamines --- dysmetabolism --- vegetarian diet --- vegan diet --- insulin resistance --- insulin sensitivity --- insulin signaling --- metabolic disorders --- hypercaloric diets --- neurodegeneration --- carob --- inositols --- D-Pinitol --- medicinal activities --- antidiabetic --- insulin regulator --- mechanismof action --- diabetes --- diagnosis --- fasting plasma glucose --- impaired fasting glycemia --- impaired glucose tolerance ---  

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Recently, the attention paid to self-care tests and the easy and large screening of a high number of people has dramatically increased. Indeed, easy and affordable tools for the safe management of biological fluids together with self-diagnosis have emerged as compulsory requirements in this time of the COVID-19 pandemic, to lighten the pressure on public healthcare institutions and thus limiting the diffusion of infections. Obviously, other kinds of pathologies (cancer or other degenerative diseases) also continue to require attention, with progressively earlier and more widespread diagnoses. The contribution to the development of this research field comes from the areas of innovative plastic and 3D microfluidics, smart chemistry and the integration of miniaturized sensors, going in the direction of improving the performances of in vitro diagnostic (IVD) devices. In our Special Issue, we include papers describing easy strategies to identify diseases at the point-of-care and near-the-bed levels, but also dealing with innovative biomarkers, sample treatments, and chemistry processes which, in perspective, represent promising tools to be applied in the field.

Research & information: general --- Biology, life sciences --- light-emitting e-textiles --- alternating current electroluminescent devices --- light emitting diodes --- light electrochemical cells --- polymeric optical fibers --- fetal stem cells --- amniotic epithelial cells --- isolation protocol --- quality control --- label-free sorting --- diagnostic tool --- glucose --- glucose oxidase --- amperometric biosensor --- body fluids --- sweat --- wearable sensor --- oral cancer --- circulating tumor cells --- micromixers --- 3D microfluidics --- biodetection --- plastic microfluidics --- microfabrication --- cornea regeneration --- tissue engineering --- nanotechnology --- molecular mechanisms --- light-emitting e-textiles --- alternating current electroluminescent devices --- light emitting diodes --- light electrochemical cells --- polymeric optical fibers --- fetal stem cells --- amniotic epithelial cells --- isolation protocol --- quality control --- label-free sorting --- diagnostic tool --- glucose --- glucose oxidase --- amperometric biosensor --- body fluids --- sweat --- wearable sensor --- oral cancer --- circulating tumor cells --- micromixers --- 3D microfluidics --- biodetection --- plastic microfluidics --- microfabrication --- cornea regeneration --- tissue engineering --- nanotechnology --- molecular mechanisms

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This Special Issue contributes original research and review articles on the role of new protein, molecular, and genetic markers used for the diagnosis and progression of civilization diseases, as well as biomarkers useful in the monitoring the effects of the implemented treatment.

Medicine --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment