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IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a frequent cause of kidney failure. Better understanding of the pathogenesis of IgAN and the related genetic, immunological, and cellular susceptibility factors are needed to enable the development of effective disease-specific therapy. This book brings together international experts to provide clinical and experimental studies and reviews with an emphasis on early diagnosis, prognosis, disease pathogenesis, determination of disease activity, and new strategies for treatment for IgAN.

Medicine --- obesity --- mesangial matrix expansion --- body mass index --- IgA nephropathy --- IgA Vasculitis --- IgA Nephropathy --- adults --- children --- presentation --- physiopathology --- genetics --- prognosis --- treatment --- IgA --- clinical trials --- kidney mesangium --- mouse model --- aberrantly glycosylated IgA1 --- galactose-deficient IgA1 --- glycosylation of IgA1 --- biomarker --- complement C3 --- O-glycosylation --- IgA1 --- autoantibody --- immune complex --- complement --- kidney --- nephrology --- IgA vasculitis --- nephritis --- kidney biopsy --- plasma cells --- CD38 --- renal pathology --- urinary galactose-deficient IgA1 --- KM55 --- crescents --- proteinuria --- glomerular filtration rate --- Oxford score --- n/a

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This reprint includes contributions from leaders in the field of personalized medicine in ophthalmology. The contributions are diverse and cover pre-clinical and clinical topics. We hope you enjoy reading the articles.

Research & information: general --- Biology, life sciences --- subthreshold micropulse laser --- 577-nm laser --- laser fixed parameters --- diabetic retinopathy --- diabetic macular edema --- optical coherence tomography --- autofluorescence --- real-life --- diabetic macular oedema --- visual prognosis --- indicators --- personalized medicine --- age-related macular degeneration --- choroidal neovascularization --- classification --- machine learning --- type 2 diabetes --- retinopathy --- ethnicity --- general practice --- risk factors --- progression --- glycemic gap --- glucose variability --- ETDRS classification --- biomarkers --- phenotypes --- anti-vascular endothelial growth factor --- diabetic retinopathy severity scale --- panretinal leakage index --- neovascular age-related macular degeneration --- anti-VEGF therapy --- retinal thickness --- visual acuity --- variability --- leakage index --- microaneurysms --- intravitreal aflibercept --- neovascularization --- ultra-widefield fluorescein angiography --- retinal imaging --- quantitative biomarkers --- precision medicine --- autoantibodies --- AT1-receptor --- PAR1 --- VEGF-A --- VEGF-B --- VEGF-receptor 2 --- AMD --- complement system --- semi-quantitative multiplex profilin --- mass spectrometry --- C4 --- vitronectin --- factor I --- genetic variants --- metabolites --- HDL --- central area thickness --- biomarker --- microRNA --- anti-VEGF --- retina --- edema --- OCT --- tomography --- microphysiological systems --- blood-neural barriers --- neurovascular unit --- disease modeling --- 3D models --- organ-on-a-chip --- inner blood-retinal barrier --- n/a

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This reprint includes contributions from leaders in the field of personalized medicine in ophthalmology. The contributions are diverse and cover pre-clinical and clinical topics. We hope you enjoy reading the articles.

Research & information: general --- Biology, life sciences --- subthreshold micropulse laser --- 577-nm laser --- laser fixed parameters --- diabetic retinopathy --- diabetic macular edema --- optical coherence tomography --- autofluorescence --- real-life --- diabetic macular oedema --- visual prognosis --- indicators --- personalized medicine --- age-related macular degeneration --- choroidal neovascularization --- classification --- machine learning --- type 2 diabetes --- retinopathy --- ethnicity --- general practice --- risk factors --- progression --- glycemic gap --- glucose variability --- ETDRS classification --- biomarkers --- phenotypes --- anti-vascular endothelial growth factor --- diabetic retinopathy severity scale --- panretinal leakage index --- neovascular age-related macular degeneration --- anti-VEGF therapy --- retinal thickness --- visual acuity --- variability --- leakage index --- microaneurysms --- intravitreal aflibercept --- neovascularization --- ultra-widefield fluorescein angiography --- retinal imaging --- quantitative biomarkers --- precision medicine --- autoantibodies --- AT1-receptor --- PAR1 --- VEGF-A --- VEGF-B --- VEGF-receptor 2 --- AMD --- complement system --- semi-quantitative multiplex profilin --- mass spectrometry --- C4 --- vitronectin --- factor I --- genetic variants --- metabolites --- HDL --- central area thickness --- biomarker --- microRNA --- anti-VEGF --- retina --- edema --- OCT --- tomography --- microphysiological systems --- blood-neural barriers --- neurovascular unit --- disease modeling --- 3D models --- organ-on-a-chip --- inner blood-retinal barrier --- subthreshold micropulse laser --- 577-nm laser --- laser fixed parameters --- diabetic retinopathy --- diabetic macular edema --- optical coherence tomography --- autofluorescence --- real-life --- diabetic macular oedema --- visual prognosis --- indicators --- personalized medicine --- age-related macular degeneration --- choroidal neovascularization --- classification --- machine learning --- type 2 diabetes --- retinopathy --- ethnicity --- general practice --- risk factors --- progression --- glycemic gap --- glucose variability --- ETDRS classification --- biomarkers --- phenotypes --- anti-vascular endothelial growth factor --- diabetic retinopathy severity scale --- panretinal leakage index --- neovascular age-related macular degeneration --- anti-VEGF therapy --- retinal thickness --- visual acuity --- variability --- leakage index --- microaneurysms --- intravitreal aflibercept --- neovascularization --- ultra-widefield fluorescein angiography --- retinal imaging --- quantitative biomarkers --- precision medicine --- autoantibodies --- AT1-receptor --- PAR1 --- VEGF-A --- VEGF-B --- VEGF-receptor 2 --- AMD --- complement system --- semi-quantitative multiplex profilin --- mass spectrometry --- C4 --- vitronectin --- factor I --- genetic variants --- metabolites --- HDL --- central area thickness --- biomarker --- microRNA --- anti-VEGF --- retina --- edema --- OCT --- tomography --- microphysiological systems --- blood-neural barriers --- neurovascular unit --- disease modeling --- 3D models --- organ-on-a-chip --- inner blood-retinal barrier

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This book includes some recent works providing the readers with novel relevant findings about the main signaling pathways that govern the molecular pathogenesis of some of the highest prevalent human tumors, which are the basis for developing alternative therapeutic strategies to improve patient outcomes.

Medicine --- Oncology --- actin cytoskeletal reorganization --- breast cancer --- CD99 agonist --- EGFR dimerization --- endocytosis --- FAK dephosphorylation --- PTPN12 --- Rac1 --- RhoA --- tripeptide --- OMD --- PRELP --- tumor suppression gene --- bladder cancer initiation --- tight junction --- partial EMT --- tousled-like kinase (TLK) --- NIMA-related kinase 1 (NEK1) --- yes-associated protein 1 (YAP1) --- thioridazine (THD) --- MS-determined phosphopeptides --- human immunodeficiency virus type 1 --- epithelial cells --- carcinogenicity --- oxidative stress --- reactive oxygen species --- gp120 --- Tat --- Nef --- matrix protein p17 --- reverse transcriptase --- mitochondria --- metastasis --- OXPHOS --- cancer --- Warburg effect --- cancer therapeutics --- myeloproliferative neoplasms --- signaling pathways --- JAK2 --- CALR --- MPL --- TPOR --- DUSP1 --- MAPK --- Snail --- prostate cancer --- migration and invasion --- patient survival --- biomarkers --- pBRD4 --- SET --- PP2A --- prognosis --- triple negative breast cancer --- resistance --- anti-receptor therapy --- trastuzumab --- PI3K --- mTOR --- TAK-228 --- epigenetic --- methylation --- acetylation --- non-coding RNA --- small-cell lung cancer --- triple-negative breast cancer --- pancreatic ductal adenocarcinoma --- glioblastoma --- metastatic melanoma --- advanced ovarian cancer --- hepatocellular carcinoma --- immune evasion --- immunotherapy --- immune checkpoint inhibitors --- oncogenic signaling pathway --- molecular targeted agents --- genome --- epigenome --- tumor immune microenvironment --- ovarian cancer --- adaptive immunity --- innate immunity --- complement system --- cancer immunology --- tumor microenvironment --- splicing pathway --- luminal breast cancer --- BET inhibitors --- n/a

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The book “Community and Family-Focused Public Health and Sustainable Development” was originally published in the renowned International Journal of Environmental Research and Public Health. This Special Issue encompassed novel aspects of applications that are connected with sustainability issues in community and family-focused public health studies. Contributions have a significant impact on solving public health problems at the family and community levels. The Special Issue originally published scientific papers, including review articles, that fell under this Special Issue’s remit and that were relevant to audiences worldwide. Currently, the term “family health” is most commonly to describe mother and child health and reproductive health. It is rare for family health to include the family as an important context for health development and that includes all family members and the family’s social environment. Authors of scientific research covering issues related to the impact of the family and the environment in which the family lives and functions on its members’ health in the present and in the future were encouraged to contribute their work. In addition, we were especially interested in scientific reports on social, economic, and health inequalities in the context of achieving the sustainable development goals.

Public health & preventive medicine --- family --- living with children --- parenthood --- mother --- father --- self-rated health --- health behavior --- mental health --- Germany --- gut microbiome --- antimicrobial activity --- pathogen overgrowth --- smoking --- tobacco smoke --- exposure to tobacco smoke --- ETS --- anti-tobacco law --- hospitality venues --- quality of life --- the elderly --- seniors --- health --- cardiovascular diseases --- physical and psychological well-being --- health behaviors --- pregnancy --- rural area --- urban area --- CHEK2 --- MEN --- Cushing syndrome --- hypertension --- multiple endocrine glands tumors --- cervix uteri --- epidemiology --- screening --- mortality --- time trends --- east-central Europe --- depression --- bone markers --- osteocalcin --- β-CTX --- vitamin D --- metabolomics --- metabolites --- amino acids --- biomarkers --- asthma --- diagnosis --- children --- community health services --- postmodern education theories --- factor analysis --- genetic testing --- umbilical cord blood banking --- women health --- air pollution --- PM2.5 --- pregnancy outcomes --- sustainable development --- spatio-temporal data --- NUTS-1 --- kernel discriminant coordinates method --- super macroregions --- proteomics --- mass spectrometry --- MALDI-MSI --- tissue imaging --- ovarian tumors --- gestational diabetes mellitus --- diabetes --- obesity --- cesarean section --- health policy --- health inequalities --- healthcare access --- spatial distribution of the health situation --- cluster analysis --- functional discriminant coordinates --- multivariate functional coefficient of variation --- adenomyosis --- infertility --- GnRH --- in vitro fertilisation --- type 1 diabetes --- proteomic profile --- C4 complement --- PURE study --- noncommunicable diseases --- urban --- rural --- FRAP --- TBARS --- anaerobic threshold --- peakVO2 --- lifestyle --- training --- exercises --- intergenerational relations --- academic youth --- standardized questionnaire WHOQOL-BREF --- alcohol --- cohort study --- PURE --- pro-health behaviours --- anti-health behaviour --- prevention --- patient --- 50+ population --- chronic diseases --- special motor fitness --- speed --- flexibility --- endurance --- physical activity --- health training --- women --- WHOQOL-BREF questionnaire --- Bangladesh --- gender violence --- multidimensional poverty --- poverty reduction --- women’s empowerment --- color vision --- anomaloscope --- Moreland --- Rayleigh --- Hashimoto’s disease --- oxidative stress --- zinc --- copper --- child health --- child nutrition --- dairy --- food security --- food systems --- nutrition --- sustainability --- sustainable food systems --- working population --- Poland --- Ukraine --- spinal cord injury --- hematological parameters --- peak oxygen uptake --- sleep duration --- bedtime --- access to health care --- health care services --- hospital emergency departments --- spatial analysis --- public health management --- testosterone --- cortisol --- creatinine --- overtraining --- family --- living with children --- parenthood --- mother --- father --- self-rated health --- health behavior --- mental health --- Germany --- gut microbiome --- antimicrobial activity --- pathogen overgrowth --- smoking --- tobacco smoke --- exposure to tobacco smoke --- ETS --- anti-tobacco law --- hospitality venues --- quality of life --- the elderly --- seniors --- health --- cardiovascular diseases --- physical and psychological well-being --- health behaviors --- pregnancy --- rural area --- urban area --- CHEK2 --- MEN --- Cushing syndrome --- hypertension --- multiple endocrine glands tumors --- cervix uteri --- epidemiology --- screening --- mortality --- time trends --- east-central Europe --- depression --- bone markers --- osteocalcin --- β-CTX --- vitamin D --- metabolomics --- metabolites --- amino acids --- biomarkers --- asthma --- diagnosis --- children --- community health services --- postmodern education theories --- factor analysis --- genetic testing --- umbilical cord blood banking --- women health --- air pollution --- PM2.5 --- pregnancy outcomes --- sustainable development --- spatio-temporal data --- NUTS-1 --- kernel discriminant coordinates method --- super macroregions --- proteomics --- mass spectrometry --- MALDI-MSI --- tissue imaging --- ovarian tumors --- gestational diabetes mellitus --- diabetes --- obesity --- cesarean section --- health policy --- health inequalities --- healthcare access --- spatial distribution of the health situation --- cluster analysis --- functional discriminant coordinates --- multivariate functional coefficient of variation --- adenomyosis --- infertility --- GnRH --- in vitro fertilisation --- type 1 diabetes --- proteomic profile --- C4 complement --- PURE study --- noncommunicable diseases --- urban --- rural --- FRAP --- TBARS --- anaerobic threshold --- peakVO2 --- lifestyle --- training --- exercises --- intergenerational relations --- academic youth --- standardized questionnaire WHOQOL-BREF --- alcohol --- cohort study --- PURE --- pro-health behaviours --- anti-health behaviour --- prevention --- patient --- 50+ population --- chronic diseases --- special motor fitness --- speed --- flexibility --- endurance --- physical activity --- health training --- women --- WHOQOL-BREF questionnaire --- Bangladesh --- gender violence --- multidimensional poverty --- poverty reduction --- women’s empowerment --- color vision --- anomaloscope --- Moreland --- Rayleigh --- Hashimoto’s disease --- oxidative stress --- zinc --- copper --- child health --- child nutrition --- dairy --- food security --- food systems --- nutrition --- sustainability --- sustainable food systems --- working population --- Poland --- Ukraine --- spinal cord injury --- hematological parameters --- peak oxygen uptake --- sleep duration --- bedtime --- access to health care --- health care services --- hospital emergency departments --- spatial analysis --- public health management --- testosterone --- cortisol --- creatinine --- overtraining