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Volgens de Cardiologische Liga heeft bijna 50% van de Belgen last van een te hoge cholesterol. In Nederland is dat volgens het Rijksinstituut voor Volksgezondheid en Milieu bij ruim 23% het geval. Omdat cholesterol hart- en vaatziekten kan veroorzaken, is het belangrijk om je cholesterolgehalte onder controle te houden. Maar wat is cholesterol eigenlijk? Wat zijn de symptomen? En mag je dan geen eitje meer bij het ontbijt of boter op je brood? Diëtiste Sanne Mouha geeft antwoord op alle vragen en legt uit hoe je met een aangepast, gezond voedingspatroon je cholesterolgehalte kunt laten dalen. En met de cholesterolarme recepten uit dit boek kun je meteen aan de slag! Wetenschappelijk onderbouwd. Heldere informatie en concrete tips. Met 30 cholesterolarme recepten

voedingsleer --- cholesterol --- recepten

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This book is written by international experts with both academic and industrial credentials. It presents for the first time, a collection of up-­to-­date scientific advances in the area of edible fats and oils technology, over a span of 10 years from 2009 to the year 2019. The book covers the existing and recent advanced techniques adopted in the edible fats and oils research and touches on the processing and modification, to the traceability and sustainability issues of fats and oils. Some recent technologies like supercritical carbon dioxide, microwave, ultrasound, and enzymatic‐ assisted processes, ionic liquid, enzymatic processes, biosensor and membrane technology are presented in the book. The book aims to provide the technologists and researchers in research, development and operations in the edible fats and oils industries with critical and readily accessible information on the recent advances in the field. The book is divided into three broad sections- Fats and Oils Chemistry and Processing, Fats and Oils Modification and Health Implications, and Fats and Oils Safety, Social, Environmental and Economic Impacts. It is an extremely comprehensive and valuable resource, which serves as an essential reference for students and lipid scientists from academia or industry.

General biochemistry --- Semiology. Diagnosis. Symptomatology --- Biotechnology --- Food science and technology --- lipiden --- voedingsleer --- cholesterol --- biotechnologie

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Cardiovascular disease (CVD), including coronary artery disease, heart disease, arrhythmias, and other types of vascular diseases, is one of the leading causes of death around the world. It is estimated that approximately half of the variabilities of CVD appear to be attributed to genetics. Therefore, the other half of them have been attributed to acquired factors, including diet. It is of note that even a genetic predisposition to CVD can be canceled out by a healthy lifestyle. In this regard, it is important to acknowledge that acquired factors, including diet, are causally associated with CVD. Based on these facts, important papers are presented in this Special Issue entitled “The Effect of Diet on Cardiovascular Disease, Heart Disease, and Blood Vessels”.

Humanities --- Social interaction --- n-3 polyunsaturated fatty acids --- cardiovascular risk estimates --- cardiovascular diseases --- biomarkers --- cardiovascular risk factors --- fish --- n-3 polyunsaturated fatty acid --- cardiovascular disease mortality --- meta-analysis --- prospective cohort studies --- body mass index --- obesity --- underweight --- ischemic stroke --- hemorrhagic stroke --- high-density lipoprotein (HDL) --- cholesterol uptake capacity (CUC) --- phospholipids (PL) --- trans-fatty acids (TFA) --- elaidic acid --- lecithin-cholesterol acyltransferase (LCAT) --- aortic stiffness --- fructose --- glucose --- hypertension --- left ventricular diastolic dysfunction --- pulse wave velocity --- renal resistive index --- cardiovascular health --- atrial fibrillation --- Japanese --- sarcopenia --- heart failure --- trimethylamine-N-oxide --- inflammatory mediators --- choline --- L-carnitine --- n/a

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Cardiovascular disease (CVD), including coronary artery disease, heart disease, arrhythmias, and other types of vascular diseases, is one of the leading causes of death around the world. It is estimated that approximately half of the variabilities of CVD appear to be attributed to genetics. Therefore, the other half of them have been attributed to acquired factors, including diet. It is of note that even a genetic predisposition to CVD can be canceled out by a healthy lifestyle. In this regard, it is important to acknowledge that acquired factors, including diet, are causally associated with CVD. Based on these facts, important papers are presented in this Special Issue entitled “The Effect of Diet on Cardiovascular Disease, Heart Disease, and Blood Vessels”.

Humanities --- Social interaction --- n-3 polyunsaturated fatty acids --- cardiovascular risk estimates --- cardiovascular diseases --- biomarkers --- cardiovascular risk factors --- fish --- n-3 polyunsaturated fatty acid --- cardiovascular disease mortality --- meta-analysis --- prospective cohort studies --- body mass index --- obesity --- underweight --- ischemic stroke --- hemorrhagic stroke --- high-density lipoprotein (HDL) --- cholesterol uptake capacity (CUC) --- phospholipids (PL) --- trans-fatty acids (TFA) --- elaidic acid --- lecithin-cholesterol acyltransferase (LCAT) --- aortic stiffness --- fructose --- glucose --- hypertension --- left ventricular diastolic dysfunction --- pulse wave velocity --- renal resistive index --- cardiovascular health --- atrial fibrillation --- Japanese --- sarcopenia --- heart failure --- trimethylamine-N-oxide --- inflammatory mediators --- choline --- L-carnitine

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Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, “ABC Transporters in Human Diseases”, is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.

ABC transporters --- drug action --- regulatory extension --- regulatory insertion --- mechanism of action --- MRP1 --- MRP4 --- breast cancer --- proliferation --- migration --- invasion --- cAMP --- ABCG2 --- ABCB1 --- blood-brain barrier --- PET --- Alzheimer’s disease --- beta-amyloid --- tariquidar --- erlotinib --- ABCG5 --- ABCG8 --- ATP-binding cassette transporter --- cholesterol --- polar relay --- sitosterolemia --- 5′ untranslated region --- cis-acting elements --- ABCA subfamily --- bioinformatics --- ABC transporter --- therapy response --- disease-free survival --- next-generation sequencing --- competitive allele-specific PCR --- P-glycoprotein --- amyloid-beta --- neuron --- SK-N-SH --- gene therapy --- AAV --- PFIC --- BSEP --- ABCB11 --- bile salts --- intrahepatic cholestasis --- chaperones --- PFIC2 --- BRIC --- ATP-binding cassette transporter A1 (ABCA1) --- cholesterol homeostasis --- reverse cholesterol transport --- HDL-C --- dyslipidemia --- type 2 diabetes --- microparticles --- ABCG2 genotype --- clinico-genetic analysis --- ethnic specificity --- genetic variations --- precision medicine --- rare variant --- Roma --- serum uric acid --- SUA-lowering therapy --- urate transporter --- bile secretion --- ABCB4 --- ABCC2 --- ABCG5/G8 --- molecular partners --- phytosterol --- xenosterol --- atherosclerosis --- gall stone --- ABC --- transporter --- ABC (ATP-binding cassette) transporters --- multidrug resistance --- transport --- trafficking --- urate --- mutations --- polymorphisms --- ABCC6 --- TNAP --- NT5E --- Pseudoxanthoma elasticum (PXE) --- cancer --- membrane protein --- functional divergence --- calcification --- pseudoxanthoma elasticum --- generalized arterial calcification of infancy --- pyrophosphate --- therapies --- ABCA7 --- phagocytosis --- Aβ peptides --- yeast --- multidrug transporter --- anticancer --- antifungal resistance --- mechanism --- peroxisome --- adrenoleukodystrophy --- fatty acids --- gout --- early-onset gout --- hyperuricemia --- uric acid --- BCRP --- single nucleotide polymorphism --- SNP --- homology modeling --- substrate-binding site --- cellular ATP efflux --- mutagenesis --- intracellular traffic --- MDR3 --- phosphatidylcholine --- RAB GTPase --- taxol --- drug transport --- n/a --- Alzheimer's disease --- 5' untranslated region