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Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy.

sonodynamic therapy --- carbon doped titanium dioxide --- sonosensitizers --- ultrasound --- cancer treatment --- breast cancer treatment --- radiotherapy --- hematological malignancies --- oxidative stress --- lymphoma --- leukemia --- multiple myeloma --- apoptosis --- mitochondria --- ultraviolet-C (UVC) --- withanolide --- combined treatment --- oral cancer --- DNA damage --- cancer therapy --- immune system --- Hypericum perforatum --- hyperforin --- reactive oxygen species --- pH regulation --- tumor prevention --- tumor therapy --- cancerogenesis --- inflammatory signaling --- natural compounds --- pancreatic cancer --- antitumor agents --- coordination polymers --- bioinorganic chemistry --- cold atmospheric plasma --- reactive oxygen and nitrogen species --- nitrite --- cancer stem cells --- chemoresistance --- glutathione --- lipid peroxidation --- ZEB-1 --- GPX4 --- ferroptosis --- HO-1 --- Nrf2 --- cancer progression --- patients --- therapy --- prognosis --- biomarker --- Eprenetapopt --- Erastin --- glutathione (GSH) --- SLC7A11 --- iron --- NRF2 --- n/a

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A collection of essential research articles and scientific reviews covering some of the most pertinent and topical areas of study that currently constitute Inorganic Chemistry in the early 21st century.

Research & information: general --- Chemistry --- Inorganic chemistry --- cyanoguanidine --- silver --- crystal structure --- chemical bonding --- CuII --- pyridine amides --- pyrazine amide --- amino benzamides --- EPR spectroscopy --- lanthanides --- Schiff base --- synthetic strategies --- single-molecule magnets --- Atomic Layer Deposition --- Ni catalyst --- reforming catalyst --- thermodynamics --- metallopharmaceuticals --- cancer stem cells --- copper --- bioinorganic chemistry --- medicinal inorganic chemistry --- reactive oxygen species --- metal-carbonyl complexes --- [FeFe]-hydrogenases --- density functional theory --- time-dependent DFT --- organometallic photochemistry --- crystalline borosilicate --- actinides --- supercritical hydrothermal synthesis --- waste forms --- thorium --- rhenium --- ruthenium --- metal–metal bonds --- uranium --- ceria --- hydrothermal --- catalysis --- nanomaterials --- crystallisation --- 4,2′:6′,4″-terpyridine --- 3,2′:6′,3″-terpyridine --- coordination polymer --- isomers --- lithium --- potassium --- Nacnac --- β-diketiminate --- tricyclohexylphenyl --- steric bulk --- silver complexes --- permanganates --- perchlorates --- perrhenate --- pyridine --- structure --- spectroscopy --- thermal behavior --- heterogenous catalyst --- metal–organic framework (MOF) --- olefin epoxidation --- carbon dioxide cycloaddition --- f-element --- lanthanide --- actinide --- multidentate ligand --- macrocycle --- ammonothermal synthesis --- fluoride --- aluminum --- speciation --- equilibria --- thermodynamic stability --- peptides --- multivariate linear regression --- poisoning effect of polar monomers --- Brookhart-type catalysts --- Zintl clusters --- X-ray crystallography --- Density Functional Theory --- n/a --- metal-metal bonds --- 4,2':6',4"-terpyridine --- 3,2':6',3"-terpyridine --- metal-organic framework (MOF)