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Current Topics in iPSCs provides a deep analysis of the underlying fundamentals that support short and mid-term developments and milestones in the business of mesenchymal stem cell therapies. This volume explores the next frontier of MSC therapies and how the transformational potential of therapeutic adult cells will be realised in all therapy areas. The impacts of clinical and economic benefits are dissected throughout each of the chapters. Written by thought leaders in the field for those curious about the interface of science and business.

Mesenchymal stem cells. --- Stem cells --- Mesenchymal Stem Cells. --- Stem Cells. --- Stem Cell Research. --- Adult Stem Cell Research --- Embryonic Stem Cell Research --- Research, Stem Cell --- Researchs, Stem Cell --- Stem Cell Researchs --- Stem Cells --- Embryo Research --- Colony-Forming Unit --- Colony-Forming Units --- Mother Cells --- Progenitor Cells --- Cell, Mother --- Cell, Progenitor --- Cell, Stem --- Cells, Mother --- Cells, Progenitor --- Cells, Stem --- Colony Forming Unit --- Colony Forming Units --- Mother Cell --- Progenitor Cell --- Stem Cell --- Cell Self Renewal --- Stem Cell Research --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Multipotent stem cells --- Therapeutic use. --- Adipose Tissue-Derived Mesenchymal Stem Cells --- Adipose Tissue-Derived Mesenchymal Stromal Cells --- Adipose-Derived Mesenchymal Stem Cells --- Adipose-Derived Mesenchymal Stromal Cells --- Bone Marrow Mesenchymal Stem Cells --- Bone Marrow Stromal Cell --- Bone Marrow Stromal Cells --- Bone Marrow Stromal Cells, Multipotent --- Bone Marrow Stromal Stem Cells --- Mesenchymal Progenitor Cell --- Mesenchymal Progenitor Cells --- Mesenchymal Stem Cell --- Mesenchymal Stem Cells, Adipose-Derived --- Mesenchymal Stromal Cells, Multipotent --- Multipotent Bone Marrow Stromal Cells --- Multipotent Mesenchymal Stromal Cells --- Stem Cells, Mesenchymal --- Wharton Jelly Cells --- Wharton's Jelly Cells --- Adipose Tissue-Derived Mesenchymal Stem Cell --- Adipose-Derived Mesenchymal Stem Cell --- Bone Marrow Mesenchymal Stem Cell --- Mesenchymal Stromal Cell --- Mesenchymal Stromal Cells --- Multipotent Bone Marrow Stromal Cell --- Multipotent Mesenchymal Stromal Cell --- Adipose Derived Mesenchymal Stem Cell --- Adipose Derived Mesenchymal Stem Cells --- Adipose Derived Mesenchymal Stromal Cells --- Adipose Tissue Derived Mesenchymal Stem Cell --- Adipose Tissue Derived Mesenchymal Stem Cells --- Adipose Tissue Derived Mesenchymal Stromal Cells --- Mesenchymal Stem Cells, Adipose Derived --- Progenitor Cell, Mesenchymal --- Progenitor Cells, Mesenchymal --- Stem Cell, Mesenchymal --- Stromal Cell, Mesenchymal --- Stromal Cells, Mesenchymal --- Wharton's Jelly Cell --- Whartons Jelly Cells --- Induced pluripotent stem cells. --- Induced pluripotent stem cells --- Induced Pluripotent Stem Cells --- Mesenchymal Stem Cells --- Mesenchymal Stem Cell Transplantation --- Induced Pluripotent Stem Cells. --- Mesenchymal Stem Cell Transplantation.

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The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-established. In this regard, there have been increased efforts towards generating potentiated/activated MSCs with enhanced therapeutic efficacy. Research on the mechanisms for enhancing MSC potency and efficacy is an area of active study with great potential for translation into clinical settings. The purpose of this book is to bring together recent research from a broad range of topics relating to potentiation strategies for enhancing MSC therapeutic efficacy, including growth factor pre-conditioning, hypoxia, and 3D culture. The research compiled in this book increases the basic understanding of MSC culture techniques and describes some MSC preparations for potential novel therapeutic applications.

cell therapy --- immunomodulation --- polyunsaturated fatty acid --- CD206 --- phagocytosis --- mesenchymal stem cells --- Vadadustat --- AKB-6548 --- preconditioning --- priming --- secretome --- chemotaxis --- Wharton’s jelly mesenchymal stem cells --- umbilical cord --- oxygen conditions --- secretory profile --- neuroprotection --- mesenchymal stromal cells --- 3D culture --- neurospheres --- spheroids --- pluripotency --- neural --- quiescence --- mesothelioma --- malignant pleural mesothelioma (MPM) --- liver cirrhosis --- placenta-derived mesenchymal stem cells --- WKYMVm --- combination therapy --- iPSC-derived MSCs --- iMSC secretome --- pre-conditioning --- angiogenesis --- IFN-γ --- hypoxia --- potentiation of iMSC efficacy --- nanofiber-hydrogel composite --- spinal cord injury --- inflammation --- macrophages --- secondary injury --- astrocytes --- axon growth --- adipose tissue-derived stem cells (ASCs) --- autophagy --- rapamycin --- 3-methyladenine --- immunosuppression --- exosome --- engineered cardiac patches --- adipose-derived stem cell --- paracrine potential --- osteogenic differentiation --- hepatocyte growth factor --- fibroblast growth factor 2