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Cardiovascular system --- Cellular signal transduction. --- Diseases. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cardiovascular diseases

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Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies covers the neuronal cell communication system in excitable cells, recognizing the most relevant mechanisms of cell communication. Along with new findings in biotechnology, medicine and pathological cases for clinicians, the book highlights electrochemical potential in living nerve and muscle cells.

Neurochemistry --- Biochemistry --- Neurosciences --- Methodology. --- Neurons --- Neural transmission --- Nervous system --- Models, Theoretical --- Signal Transduction --- Nervous System Diseases --- Muscular Diseases --- Physiology --- Mathematical models. --- Diseases --- physiology

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This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.

Histology. Cytology --- Immunology. Immunopathology --- immunologie --- cytologie --- histologie --- Immunology. --- Immune system. --- Cellular signal transduction. --- Cytology. --- Autoimmunity. --- Immunospecificity. --- Immune Cell Signalling. --- Cell Biology. --- Adaptive Immunity. --- Fosfatidilinositols --- Immunitat cel·lular

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Protein-protein interactions. --- Human molecular genetics. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Human genetics --- Molecular genetics --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association

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The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research.

Research & information: general --- elastin --- ribosomal protein SA --- tongue carcinoma --- MMP-2 --- EGCG --- pancreatic ductal adenocarcinoma --- syndecans --- proteoglycans --- tumor progression --- angiogenesis --- syndecan-4 --- heparan sulfate --- cancer --- prognosis --- biomarker --- signal transduction --- proteoglycan --- metastasis --- extracellular matrix --- fibrosis --- immune cell modulation --- neutrophils --- neutrophil extracellular trap --- macrophages --- BCC --- MMP --- TIMP --- invasion --- lumican --- cancer cell growth --- motility --- hyaluronan --- RHAMM --- CD44 --- wound repair --- breast cancer --- malignant pleural mesothelioma --- pleural effusion --- extracellular vesicles --- biomarkers --- sulfated hyaluronan --- estrogen receptors --- epithelial-to-mesenchymal transition --- matrix metalloproteinases --- elastin --- ribosomal protein SA --- tongue carcinoma --- MMP-2 --- EGCG --- pancreatic ductal adenocarcinoma --- syndecans --- proteoglycans --- tumor progression --- angiogenesis --- syndecan-4 --- heparan sulfate --- cancer --- prognosis --- biomarker --- signal transduction --- proteoglycan --- metastasis --- extracellular matrix --- fibrosis --- immune cell modulation --- neutrophils --- neutrophil extracellular trap --- macrophages --- BCC --- MMP --- TIMP --- invasion --- lumican --- cancer cell growth --- motility --- hyaluronan --- RHAMM --- CD44 --- wound repair --- breast cancer --- malignant pleural mesothelioma --- pleural effusion --- extracellular vesicles --- biomarkers --- sulfated hyaluronan --- estrogen receptors --- epithelial-to-mesenchymal transition --- matrix metalloproteinases