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COVID-19 diagnostic strategies based on advanced techniques are currently essential topics of interest, with crucial roles in scientific research. This book integrates fundamental concepts and critical analyses that explore the progress of modern methods for the detection of SARS-CoV-2.

Research & information: general --- Biology, life sciences --- biosensor --- COVID-19 diagnosis --- SARS-CoV-2 --- surface plasmon resonance --- field-effect transistor --- electrochemical --- a point-of-care device --- immunochromatography --- test strips --- surface antigen --- Raman spectra --- nucleocapsid protein --- signal amplification --- copper deposition --- neutralizing antibody --- latex microspheres --- lateral flow immunoassay --- receptor binding domain --- COVID-19 --- microfluidic --- chip --- biosensors --- diagnostics --- spike glycoprotein --- epitope --- electrochemical biosensor --- point of care --- immunological diagnostic --- SARSC-CoV-2 --- surface plasmonic resonance (SPR) --- spike protein --- point-of-care testing --- photonics --- antibodies --- serology --- SH-SAW biosensor --- vaccine --- antibody --- seroprevalence --- humoral immunity --- microfluidics --- clinical decision support tool --- optical biosensors --- machine learning --- nonlinear optics --- diagnosis --- n/a

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Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role.

Research & information: general --- Chemistry --- thiazole --- piperazine --- tail-clip --- hot-plate --- acetic acid-induced writhing test --- opioid --- prodynorphin --- epigenetics --- transcription --- human brain --- morphine dosing --- behavior --- locomotor activity --- tolerance --- µ-opioid receptor --- DAMGO --- SR-17018 --- buprenorphine --- nalbuphine --- kappa opioid receptor agonist --- pruritis --- scratching --- mice --- TAT-HIV --- cholestasis --- chloroquine --- deoxycholic acid --- analgesic --- δ opioid receptor --- G-protein-biased agonist --- opioid peptide --- rubiscolins --- µ-opioid analgesics --- angiotensin receptors --- chronic pain --- neuropathic pain --- delta opioid receptor --- inverse agonist --- irreversible antagonist --- non-competitive antagonist --- molecular pharmacology --- free fatty acid receptors --- lipids --- opioid receptor --- colitis --- chemotype --- high-throughput screen --- allosteric modulation --- beta-arrestin --- molecular dynamics --- opioid receptors --- β-amino acids --- peptide synthesis --- receptor binding studies --- functional assay --- nociceptin/orphanin FQ receptor --- NOP receptor --- ligands --- nociceptin --- N/OFQ --- analgesia --- GPCR --- HS-731 --- peripheral opioid agonist --- binding --- selectivity --- molecular docking --- molecular dynamics simulations --- n/a --- fluorescence cross-correlation spectroscopy (FCCS) --- G protein-coupled receptor (GPCR) --- serotonin

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Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role.

thiazole --- piperazine --- tail-clip --- hot-plate --- acetic acid-induced writhing test --- opioid --- prodynorphin --- epigenetics --- transcription --- human brain --- morphine dosing --- behavior --- locomotor activity --- tolerance --- µ-opioid receptor --- DAMGO --- SR-17018 --- buprenorphine --- nalbuphine --- kappa opioid receptor agonist --- pruritis --- scratching --- mice --- TAT-HIV --- cholestasis --- chloroquine --- deoxycholic acid --- analgesic --- δ opioid receptor --- G-protein-biased agonist --- opioid peptide --- rubiscolins --- µ-opioid analgesics --- angiotensin receptors --- chronic pain --- neuropathic pain --- delta opioid receptor --- inverse agonist --- irreversible antagonist --- non-competitive antagonist --- molecular pharmacology --- free fatty acid receptors --- lipids --- opioid receptor --- colitis --- chemotype --- high-throughput screen --- allosteric modulation --- beta-arrestin --- molecular dynamics --- opioid receptors --- β-amino acids --- peptide synthesis --- receptor binding studies --- functional assay --- nociceptin/orphanin FQ receptor --- NOP receptor --- ligands --- nociceptin --- N/OFQ --- analgesia --- GPCR --- HS-731 --- peripheral opioid agonist --- binding --- selectivity --- molecular docking --- molecular dynamics simulations --- n/a --- fluorescence cross-correlation spectroscopy (FCCS) --- G protein-coupled receptor (GPCR) --- serotonin

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Since first receiving approval in 1986, antibody-based therapeutics have been the most successful modality for the treatment of various diseases. This Special Issue of IJMS, “Recent Advances in Antibody Therapeutics”, presents leading-edge articles and reviews for discovery, development, and clinical applications of therapeutic antibodies, covering antibody drug conjugates (ADCs), GPCR-targeting antibodies, a functional antibody screening, bioassay of bispecific antibodies, antibody applications for cardiovascular diseases, antibody delivery to CNS, etc. The excellent studies in this Special Issue would valuable insight for scientists and clinicians in the field of therapeutic antibodies

Research & information: general --- Chemistry --- interleukin 33 --- ST2 receptor --- scFv --- C2_2E12 --- bladder cancer --- antibodies --- immune checkpoint inhibitors --- antibody-drug conjugates --- sacituzumab govitecan --- enfortumab vedotin --- erdafitinib --- cost-effectiveness --- G protein-coupled receptor --- membrane protein --- antigen --- therapeutic antibody --- anti-angiogenesis --- delta-like ligand --- irinotecan --- paclitaxel --- VEGF --- SARS-CoV-2 --- spike protein --- receptor-binding domain --- phage display --- monoclonal antibody --- cytomegalovirus --- peptide/major histocompatibility complex class I complex --- T-cell-receptor-like antibody --- affinity maturation --- yeast surface display --- combinatorial antibody library --- agonist antibody --- cell fate --- bispecific antibodies --- bioassays --- mechanisms of action --- binding assays --- potency assays --- atherosclerosis --- inflammation --- antibody therapy --- blood-brain barrier --- antibody --- pharmacokinetics --- disposition --- biochemical and physicochemical properties --- Fc binding --- receptor-mediated transcytosis --- brain shuttle --- molecular Trojan horse --- transferrin --- anti-cancer antibody --- antibody engineering --- biophysical properties --- computational methods --- research cell bank --- antibody therapeutics --- recombinant antibodies --- intracellular antibodies --- single-chain antibody fragment --- nanobody --- Human papillomaviruses --- HPV oncoproteins --- HPV-associated cancer --- HPV cancer therapy --- asthma --- refractory asthma --- biomarker --- interleukin 33 --- ST2 receptor --- scFv --- C2_2E12 --- bladder cancer --- antibodies --- immune checkpoint inhibitors --- antibody-drug conjugates --- sacituzumab govitecan --- enfortumab vedotin --- erdafitinib --- cost-effectiveness --- G protein-coupled receptor --- membrane protein --- antigen --- therapeutic antibody --- anti-angiogenesis --- delta-like ligand --- irinotecan --- paclitaxel --- VEGF --- SARS-CoV-2 --- spike protein --- receptor-binding domain --- phage display --- monoclonal antibody --- cytomegalovirus --- peptide/major histocompatibility complex class I complex --- T-cell-receptor-like antibody --- affinity maturation --- yeast surface display --- combinatorial antibody library --- agonist antibody --- cell fate --- bispecific antibodies --- bioassays --- mechanisms of action --- binding assays --- potency assays --- atherosclerosis --- inflammation --- antibody therapy --- blood-brain barrier --- antibody --- pharmacokinetics --- disposition --- biochemical and physicochemical properties --- Fc binding --- receptor-mediated transcytosis --- brain shuttle --- molecular Trojan horse --- transferrin --- anti-cancer antibody --- antibody engineering --- biophysical properties --- computational methods --- research cell bank --- antibody therapeutics --- recombinant antibodies --- intracellular antibodies --- single-chain antibody fragment --- nanobody --- Human papillomaviruses --- HPV oncoproteins --- HPV-associated cancer --- HPV cancer therapy --- asthma --- refractory asthma --- biomarker