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This volume explores detailed methods to investigate various aspects of biology related to cell polarity, or asymmetry within a cell. Molecular, cellular, and tissue-level regulation and function as well as diseases caused by impairment of cell polarity are explored by these methods. Beginning with advanced imaging and biochemical methods, the book continues with planar cell polarity (PCP) signaling in morphogenesis in diverse developmental contexts, apicobasal (AB) cell polarity in development and diseases, as well as directional cell migration and biomechanics in cell polarity. The collection includes the usage of a wide variety of model systems and an extensive array of techniques, including genetic, imaging, biochemical, and biomechanical. Written for the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Cell Polarity Signaling: Methods and Protocols aims to enable researchers to delve into the stimulating field of cell polarity and contribute to our understanding of how coordinated control of protein stability, trafficking, membrane retention, post-translational modification, and dynamic organization leads to active regulation of cell polarity. Chapter 29 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Cytology. --- Polarity (Biology). --- Cell Polarity. --- Cell Biology. --- Biology --- Tissues --- Cell biology --- Cellular biology --- Cells

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Good and evil. --- Good and evil --- Biblical teaching. --- Evil --- Wickedness --- Ethics --- Philosophy --- Polarity --- Religious thought

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The human world is alive with different sorts of goods - the multifarious things we all see as worth achieving or celebrating by our action and in our living. Timothy Chappell argues that we can't live well, still less think well about ethics, if we don't properly understand these issues. Venturing into new ground, he surveys the central topics in philosophy, providing an historical and philosophical map of the major themes. From utilitarianism, Kantianism, virtue ethics, personal identity, Parfitian reductionism, animals, abortion and euthanasia, to free will and the meaning of life itself, he takes us on an original and thought-provoking journey through ethics.

Ethics. --- Good and evil. --- PHILOSOPHY / General. --- Evil --- Wickedness --- Ethics --- Philosophy --- Polarity --- Religious thought --- Deontology --- Ethics, Primitive --- Ethology --- Moral philosophy --- Morality --- Morals --- Philosophy, Moral --- Science, Moral --- Values

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How can works of the imagination help us to understand good and evil in the modern world? In this new collection of essays, Alex Danchev treats the artist as a crucial moral witness of our troubled times, and puts art to work in the service of political and ethical inquiry.

Good and evil --- Arts and morals. --- Arts and ethics --- Ethics and the arts --- Morals and the arts --- Evil --- Wickedness --- Ethics --- Philosophy --- Polarity --- Religious thought --- Psychological aspects. --- Philosophy. --- Arts --- Good and evil in art. --- Moral and ethical aspects. --- Poitras, Laura. --- Kiefer, Anselm, --- Mucha, Reinhard, --- Evil in art --- Arts, Fine --- Arts, Occidental --- Arts, Western --- Fine arts --- Humanities --- Arts, Primitive

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"Die vorliegende Arbeit untersucht, inwiefern das Böse die Systemidentität der christlichen Wirklichkeitsperspektive konstitutiv mitbestimmt. Ausgangspunkt ist dabei die Beobachtung, dass Theologie explizit heuristisch die Reflexion über das Böse vorantreiben muss, da sie weder der Vielstimmigkeit der Postmoderne das Wort reden noch dogmatistisch resignieren kann. Dies will die Arbeit mithilfe eines modelltheoretischen Zugangs leisten. Nach einer methodischen Orientierung zum Modellbegriff wird die strukturelle Rolle des Bösen bei sechs Autoren (früher und später Augustinus, Leibniz, Schelling, Hegel, Boyd) analysiert. Die dabei identifizierten Positionsunterschiede werfen zwölf Leitfragen auf, welche im modellsynthetischen Teil die Rekonstruktion von Freiheit, Gott und dem Bösen als Relate des christlichen Wirklichkeitsverständnisses orientieren. Auf Basis dieser Rekonstruktion kann schließlich gezeigt werden, dass dem Bösen keine konstitutive Rolle im christlichen Wirklichkeitsverständnis zukommen kann. Da aber endliche Freiheit unweigerlich das Böse in ihrer Individuation hervorbringt, stellt das Böse aufgrund der Identität des Individuums auch im futurischen Eschaton ein Relat dar – obgleich in transformierter Weise."

Good and evil --- Free will and determinism --- Evil --- Wickedness --- Ethics --- Philosophy --- Polarity --- Religious thought --- Theology --- Religious aspects --- Christianity --- Theodicy. --- economy of salvation. --- model theory. --- reconciliation. --- 216 --- 216 Bien et mal. Origine du mal --- 216 Goed en kwaad --- Bien et mal. Origine du mal --- Goed en kwaad --- Theology. --- Christianity.