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This reprint includes 15 articles in the field of non-communicable Diseases, big data, and artificial intelligence, overviewing the most recent advances in the field of AI and their application potential in 3P medicine.

Medicine --- artificial intelligence --- computer-aided diagnosis --- facial phenotypes --- machine learning --- complexity theory --- dementia --- cognitive dysfunction --- neuropsychological tests --- mental status and dementia tests --- spontaneous intracerebral hemorrhage (SICH) --- 90-day function outcome --- mortality --- osteoarthritis --- venous thrombosis --- VTE risk prediction --- machine learning algorithm --- population-based cohort study --- pituitary adenoma --- craniopharyngioma --- optic chiasm --- multicenter --- treatment outcome --- liver neoplasms --- deep learning --- diabetic complication --- gene-gene interaction --- AGER --- IL6R --- multiple sclerosis --- DNA methylation --- entropy --- atherosclerosis --- plaque characterization --- physical activity --- osteoporosis --- osteoporotic fracture --- vertebral fracture --- hip fracture --- distal radius fracture --- small for gestational age --- exposure to radiation --- prediction --- coronary plaque --- major adverse cardiovascular events --- coronary artery disease --- coronary computed tomographic angiography --- acute pancreatitis --- predictor --- interventions --- type 2 diabetes mellitus (T2DM) --- prediction model --- Chinese elderly --- prediabetes --- incident diabetes --- predictive models --- artificial intelligence --- computer-aided diagnosis --- facial phenotypes --- machine learning --- complexity theory --- dementia --- cognitive dysfunction --- neuropsychological tests --- mental status and dementia tests --- spontaneous intracerebral hemorrhage (SICH) --- 90-day function outcome --- mortality --- osteoarthritis --- venous thrombosis --- VTE risk prediction --- machine learning algorithm --- population-based cohort study --- pituitary adenoma --- craniopharyngioma --- optic chiasm --- multicenter --- treatment outcome --- liver neoplasms --- deep learning --- diabetic complication --- gene-gene interaction --- AGER --- IL6R --- multiple sclerosis --- DNA methylation --- entropy --- atherosclerosis --- plaque characterization --- physical activity --- osteoporosis --- osteoporotic fracture --- vertebral fracture --- hip fracture --- distal radius fracture --- small for gestational age --- exposure to radiation --- prediction --- coronary plaque --- major adverse cardiovascular events --- coronary artery disease --- coronary computed tomographic angiography --- acute pancreatitis --- predictor --- interventions --- type 2 diabetes mellitus (T2DM) --- prediction model --- Chinese elderly --- prediabetes --- incident diabetes --- predictive models

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This reprint includes 15 articles in the field of non-communicable Diseases, big data, and artificial intelligence, overviewing the most recent advances in the field of AI and their application potential in 3P medicine.

Medicine --- artificial intelligence --- computer-aided diagnosis --- facial phenotypes --- machine learning --- complexity theory --- dementia --- cognitive dysfunction --- neuropsychological tests --- mental status and dementia tests --- spontaneous intracerebral hemorrhage (SICH) --- 90-day function outcome --- mortality --- osteoarthritis --- venous thrombosis --- VTE risk prediction --- machine learning algorithm --- population-based cohort study --- pituitary adenoma --- craniopharyngioma --- optic chiasm --- multicenter --- treatment outcome --- liver neoplasms --- deep learning --- diabetic complication --- gene-gene interaction --- AGER --- IL6R --- multiple sclerosis --- DNA methylation --- entropy --- atherosclerosis --- plaque characterization --- physical activity --- osteoporosis --- osteoporotic fracture --- vertebral fracture --- hip fracture --- distal radius fracture --- small for gestational age --- exposure to radiation --- prediction --- coronary plaque --- major adverse cardiovascular events --- coronary artery disease --- coronary computed tomographic angiography --- acute pancreatitis --- predictor --- interventions --- type 2 diabetes mellitus (T2DM) --- prediction model --- Chinese elderly --- prediabetes --- incident diabetes --- predictive models

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This reprint includes 15 articles in the field of non-communicable Diseases, big data, and artificial intelligence, overviewing the most recent advances in the field of AI and their application potential in 3P medicine.

artificial intelligence --- computer-aided diagnosis --- facial phenotypes --- machine learning --- complexity theory --- dementia --- cognitive dysfunction --- neuropsychological tests --- mental status and dementia tests --- spontaneous intracerebral hemorrhage (SICH) --- 90-day function outcome --- mortality --- osteoarthritis --- venous thrombosis --- VTE risk prediction --- machine learning algorithm --- population-based cohort study --- pituitary adenoma --- craniopharyngioma --- optic chiasm --- multicenter --- treatment outcome --- liver neoplasms --- deep learning --- diabetic complication --- gene-gene interaction --- AGER --- IL6R --- multiple sclerosis --- DNA methylation --- entropy --- atherosclerosis --- plaque characterization --- physical activity --- osteoporosis --- osteoporotic fracture --- vertebral fracture --- hip fracture --- distal radius fracture --- small for gestational age --- exposure to radiation --- prediction --- coronary plaque --- major adverse cardiovascular events --- coronary artery disease --- coronary computed tomographic angiography --- acute pancreatitis --- predictor --- interventions --- type 2 diabetes mellitus (T2DM) --- prediction model --- Chinese elderly --- prediabetes --- incident diabetes --- predictive models

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The book gives an overview on the progress that has been made in the treatment of acute lymphoblastic leukemia (ALL), of acute and chronic myeloid leukemia (AML, CML) and of juvenile myelomonocytic leukemia (JMML). Leukemia is the most common malignant disease in children, and 80% of patients are diagnosed with ALL and 15–20% with AML, whereas CML and JMML are rather rare. Although ALL was considered an incurable disease until the early 1960s, with the availability of cytotoxic drugs and the start of clinical multicenter studies, ALL has become an almost curable disease with a survival rate exceeding 90 % in high-income countries. These impressive results have mainly been achieved by a deeper understanding of the genomic landscape of the disease and the introduction of risk stratifications based on genetic features and response to chemotherapy as determined by the presence or absence of minimal residual disease (MRD). Immunotherapies including bispecific T-cell Engagers (BiTEs), Chimeric Antigen Receptor (CAR) T cells, monoclonal antibodies and improvements in the outcome of allogeneic stem cell transplantation (HSCT) have shown impressive results in chemorefractory or relapsed patients, and it is anticipated that the cure rate can be further increased. For countries with less resources, therapies have to be adapted to increase survival as well. This book also updates on the progress made in the treatment of AML. As in ALL, risk classification based on genetic factors and response to chemotherapy is most important for therapy guidance. The book also provides updates and guidance for the treatment of CML and JMML.

acute lymphoblastic leukemia --- pediatric --- advances --- diagnosis --- treatment --- immunotherapy --- bispecific T-cell engager (BiTE) --- BCP-ALL --- leukemia --- TRAIL --- antibody --- Fc-engineering --- xenograft --- CD19 --- juvenile myelomonocytic leukemia --- RAS signaling --- hematopoietic stem cell transplantation --- 5-azacitidine --- myelodysplastic/myeloproliferative disorders --- targeted therapy --- ADC --- antibody–drug conjugate --- pediatric leukemia --- ALL --- AML --- allogeneic stem cell transplantation --- acute myeloid leukemia --- minimal residual disease --- conditioning regimen --- alternative donors --- B-ALL --- DUX4 --- IKZF1 --- PAX5 --- Ph-like --- ZNF384 --- NUTM1 --- T-ALL --- NOTCH1 --- BCL11B --- transcriptome --- genome --- chronic myeloid leukemia --- CML --- tyrosine kinase inhibitor --- immunizations --- COVID-19 --- childhood acute lymphoblastic leukemia --- low-risk ALL --- risk-stratified treatment --- treatment related toxicity --- L-asparaginase --- acute pancreatitis --- polymorphism --- SNV --- ABCC4 --- CFTR --- other extramedullary relapse --- lymphoblastic leukemia --- children --- prognosis --- evolution of CAR T cells --- FDA-approved CAR products --- TcR versus CAR --- limitations and complications of CAR T cell therapy --- future directions of CAR T cell therapy --- n/a --- antibody-drug conjugate

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Gastrointestinal tract disorders are a wide group of diseases involving both the gastrointestinal tube (esophagus, stomach, small and large intestine) and related organs (liver, pancreas, and gallbladder). These dysfunctions may differ by site, etiology, and severity, going from simple malfunctions to mere diseases. Because of their variety and heterogeneity, gastrointestinal disorders can affect many people and are widespread throughout the population. Therefore, scientific research in this area is facing a great challenge. Better knowledge of gastrointestinal disorders in terms of their pathophysiology, clinical features, and possible complications is necessary for the development of new diagnostic methods and therapeutic strategies. During the last several decades, some scientific developments have already been made, giving more opportunities to these patients. However, much remains to be discovered and to be done to help physicians in their everyday work and to give patients a better prognosis. The present Special Issue aims to highlight recent advances in gastrointestinal tract disorders, focusing on their diagnostic and therapeutic path, evolution, and complications.

Research & information: general --- Chemistry --- Crohn's disease --- ulcerative colitis --- biologics --- anemia --- gastroesophageal reflux --- cough --- asthma --- laryngo-pharyngeal reflux --- chest pain --- tooth erosions --- inflammatory bowel diseases --- sleep disorders --- sleep medicine --- PPI --- diverticulosis --- diverticulitis --- risk factors --- Marfan's syndrome --- diverticula --- abdominal symptoms --- ultrasound --- infant --- food allergy --- fecal biomarkers --- tumor necrosis factor α --- eosinophil derived neurotoxin --- calprotectin --- Emorsan®Gel --- hemorrhoidal disease --- hemorrhoidectomy --- pain --- wound healing --- chronic idiopathic constipation --- constipation --- irritable bowel syndrome --- pathophysiology --- primary care --- medical students --- public health --- social media --- dietary habit --- pandemic --- dyspepsia --- diabetes --- gastroparesis --- inflammatory bowel disease --- SCORE --- carotid plaques --- cardiovascular risk --- dyssynergic defecation --- slow transit constipation --- motility --- colonic transit --- anorectal manometry --- gastrointestinal disorders --- endoscopic vacuum therapy --- etiology --- transmural defect --- upper gastrointestinal tract --- Helicobacter pylori --- eradication --- antibiotic resistance --- tailored --- empirical --- gastrointestinal bleeding --- new oral anticoagulants --- vitamin K antagonist --- rebleeding --- chronic gastritis --- peptic ulcer disease --- gastric cancer --- MALT-lymphoma --- therapy --- vaccines --- DA-9701 --- diabetic mouse model --- functional dyspepsia --- diabetic gastroparesis --- STZ --- gastrointestinal motility --- human leukocyte antigen --- celiac disease --- autoimmune hepatitis --- primary sclerosing cholangitis --- primary biliary cholangitis --- autoimmune pancreatitis --- IgG4-related sclerosing cholangitis --- IgG4-related hepatopathy --- Crohn's disease --- ulcerative colitis --- biologics --- anemia --- gastroesophageal reflux --- cough --- asthma --- laryngo-pharyngeal reflux --- chest pain --- tooth erosions --- inflammatory bowel diseases --- sleep disorders --- sleep medicine --- PPI --- diverticulosis --- diverticulitis --- risk factors --- Marfan's syndrome --- diverticula --- abdominal symptoms --- ultrasound --- infant --- food allergy --- fecal biomarkers --- tumor necrosis factor α --- eosinophil derived neurotoxin --- calprotectin --- Emorsan®Gel --- hemorrhoidal disease --- hemorrhoidectomy --- pain --- wound healing --- chronic idiopathic constipation --- constipation --- irritable bowel syndrome --- pathophysiology --- primary care --- medical students --- public health --- social media --- dietary habit --- pandemic --- dyspepsia --- diabetes --- gastroparesis --- inflammatory bowel disease --- SCORE --- carotid plaques --- cardiovascular risk --- dyssynergic defecation --- slow transit constipation --- motility --- colonic transit --- anorectal manometry --- gastrointestinal disorders --- endoscopic vacuum therapy --- etiology --- transmural defect --- upper gastrointestinal tract --- Helicobacter pylori --- eradication --- antibiotic resistance --- tailored --- empirical --- gastrointestinal bleeding --- new oral anticoagulants --- vitamin K antagonist --- rebleeding --- chronic gastritis --- peptic ulcer disease --- gastric cancer --- MALT-lymphoma --- therapy --- vaccines --- DA-9701 --- diabetic mouse model --- functional dyspepsia --- diabetic gastroparesis --- STZ --- gastrointestinal motility --- human leukocyte antigen --- celiac disease --- autoimmune hepatitis --- primary sclerosing cholangitis --- primary biliary cholangitis --- autoimmune pancreatitis --- IgG4-related sclerosing cholangitis --- IgG4-related hepatopathy