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Brazilian literature --- Brazilian literature. --- Civilization. --- History and criticism --- Brazil --- Brazil. --- Civilization --- communication --- mass media --- journalism --- film --- new technologies

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This Special Issue is aimed to offer an overview of studies presenting new rehabilitation approaches addressed to children with neurodevelopmental disorders, designed to enhance the effects of learning processes through the use of new technologies. The contributions of this Special Issue, authored by researchers and clinicians from some of the most valued Italian scientific institutions in the field of neurodevelopmental disorders, can offer some useful data and advice on the use of technology in rehabilitation and telerehabilitation to researchers, rehabilitators, clinicians and pratictioners (psychologists, neuropsychologists, speech therapists, etc.).

Medicine --- neurorehabilitation --- cognitive enhancement in children --- tech mediated rehabilitation --- developmental coordination disorders --- virtual reality --- telerehabilitation --- specific learning disorders --- cerebral palsy --- well-being --- dyslexia --- rhythm --- music therapy --- intervention --- developmental dyslexia --- new technologies --- augmented reality --- good practices --- Delphi method --- rehabilitation --- remote intervention --- children --- age --- severity --- improvement --- follow-up --- n/a

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Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10–15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed “nonobstructive azoospermia” (NOA) to differentiate it from the less severe form of azoospermia caused by the obstruction of the seminal tract (obstructive azoospermia—OA), the latter affecting the remaining one-third of cases. Managing patients with NOA is challenging due to the severity of spermatogenic dysfunction and the lack of medical treatments, with surgical retrieval of testicular sperm being the only way of enabling some of these patients to father their own biological children. In-depth clinical knowledge is key for supporting clinical reasoning and decision making when counselling patients with NOA, and surgical skill is required to maximize the outcome of surgical procedures that aim to retrieve testicular sperm. The present book is a collection of scientific papers published in a Special Issue of the Journal of Clinical Medicine, authored by some of the most influential researchers in the field. The Special Issue, and thus also this book, were conceived to provide early career reproductive urologists and endocrinologists with an update of the scientific evidence in the field, together with surgical tips.

Medicine --- Pharmacology --- nonobstructive azoospermia --- micro-TESE --- FSH treatment --- hormonal treatment --- testosterone level --- microdissection testicular sperm extraction --- non-obstructive azoospermia --- management --- infertility --- intracytoplasmic sperm injection --- testicular azoospermia --- sperm selection --- sperm --- cryopreservation --- in vitro maturation --- azoospermia --- diagnosis --- male infertility --- spermatogenic failure --- testis biopsy --- sperm retrieval --- genetic testing --- endocrine evaluation --- review --- hypogonadism --- Sertoli cell-only syndrome --- testicular spermatozoa --- processing --- microfluidics --- new technologies --- genetics --- exome --- WES --- Y chromosome --- cancer --- NOA --- genes --- general health --- ICSI --- offspring health --- microTESE --- prediction model --- nonobstructive azoospermia --- micro-TESE --- FSH treatment --- hormonal treatment --- testosterone level --- microdissection testicular sperm extraction --- non-obstructive azoospermia --- management --- infertility --- intracytoplasmic sperm injection --- testicular azoospermia --- sperm selection --- sperm --- cryopreservation --- in vitro maturation --- azoospermia --- diagnosis --- male infertility --- spermatogenic failure --- testis biopsy --- sperm retrieval --- genetic testing --- endocrine evaluation --- review --- hypogonadism --- Sertoli cell-only syndrome --- testicular spermatozoa --- processing --- microfluidics --- new technologies --- genetics --- exome --- WES --- Y chromosome --- cancer --- NOA --- genes --- general health --- ICSI --- offspring health --- microTESE --- prediction model

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This research topic aims at enterprise-wide modeling and optimization (EWMO) through the development and application of integrated modeling, simulation and optimization methodologies, and computer-aided tools for reliable and sustainable improvement opportunities within the entire manufacturing network (raw materials, production plants, distribution, retailers, and customers) and its components. This integrated approach incorporates information from the local primary control and supervisory modules into the scheduling/planning formulation. That makes it possible to dynamically react to incidents that occur in the network components at the appropriate decision-making level, requiring fewer resources, emitting less waste, and allowing for better responsiveness in changing market requirements and operational variations, reducing cost, waste, energy consumption and environmental impact, and increasing the benefits. More recently, the exploitation of new technology integration, such as through semantic models in formal knowledge models, allows for the capture and utilization of domain knowledge, human knowledge, and expert knowledge toward comprehensive intelligent management. Otherwise, the development of advanced technologies and tools, such as cyber-physical systems, the Internet of Things, the Industrial Internet of Things, Artificial Intelligence, Big Data, Cloud Computing, Blockchain, etc., have captured the attention of manufacturing enterprises toward intelligent manufacturing systems.

Technology: general issues --- History of engineering & technology --- manufacturing process --- additive manufacturing --- IoT --- computer systems and networks --- 3D printing --- digital twin --- Industry 4.0 --- pharmaceutical manufacturing --- biopharmaceutical manufacturing --- process modeling --- mixed-integer linear programming --- bin-packing problem --- material requirements planning --- agri-supply chain management --- variable production rate --- optimal resources --- imperfect production --- eco-efficient production --- closed-loop scheduling --- scheduling stability --- optimal control and scheduling --- fouling --- heat exchanger networks --- continuous manufacturing --- bioprocessing --- process systems engineering --- single-use technology --- AGV—Automated Guided Vehicles --- DES—Discrete Event Simulation --- FMS—Flexible Manufacturing Systems --- OEE—Overall Equipment Efficiency --- WCLcWorld Class Logistic --- abrasive water jet --- cutting --- surface quality --- quality prediction --- 3D simulation modeling and analysis --- model implementation --- bottleneck analysis --- production costs --- resource conservation --- smart manufacturing --- edge computing --- machine learning --- blockchain --- Industrial Internet of Things --- inventory management --- supply chain --- multi-echelon --- stochastic programming --- reinforcement learning --- digitalisation --- model-based --- computational engineering --- process simulation --- LNG terminal --- operational optimization --- BOG compressor --- MINLP --- enterprise process architecture --- new technologies integration --- process intelligence --- real-time monitoring --- fault detection --- predictive process adjustment --- vacuum gripper --- sensor data --- Tri-X Intelligence --- cyber-physical systems --- human-cyber systems --- intelligent systems --- intelligent manufacturing --- multi-parametric programming --- explicit MPC --- enterprise-wide optimisation --- set-point tracking --- algebraic geometry --- continuous pharmaceutical manufacturing --- model predictive control --- state estimation --- quality-by-control (QbC) --- glidant effects --- plant-model mismatch --- regional logistics --- low-carbon economy --- cloud model --- comprehensive evaluation --- Beijing-Tianjin-Hebei region --- pharmaceutical manufacture --- uncertainty --- operational flexibility --- operational envelopes --- modeling --- n/a --- AGV-Automated Guided Vehicles --- DES-Discrete Event Simulation --- FMS-Flexible Manufacturing Systems --- OEE-Overall Equipment Efficiency

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This research topic aims at enterprise-wide modeling and optimization (EWMO) through the development and application of integrated modeling, simulation and optimization methodologies, and computer-aided tools for reliable and sustainable improvement opportunities within the entire manufacturing network (raw materials, production plants, distribution, retailers, and customers) and its components. This integrated approach incorporates information from the local primary control and supervisory modules into the scheduling/planning formulation. That makes it possible to dynamically react to incidents that occur in the network components at the appropriate decision-making level, requiring fewer resources, emitting less waste, and allowing for better responsiveness in changing market requirements and operational variations, reducing cost, waste, energy consumption and environmental impact, and increasing the benefits. More recently, the exploitation of new technology integration, such as through semantic models in formal knowledge models, allows for the capture and utilization of domain knowledge, human knowledge, and expert knowledge toward comprehensive intelligent management. Otherwise, the development of advanced technologies and tools, such as cyber-physical systems, the Internet of Things, the Industrial Internet of Things, Artificial Intelligence, Big Data, Cloud Computing, Blockchain, etc., have captured the attention of manufacturing enterprises toward intelligent manufacturing systems.

Technology: general issues --- History of engineering & technology --- manufacturing process --- additive manufacturing --- IoT --- computer systems and networks --- 3D printing --- digital twin --- Industry 4.0 --- pharmaceutical manufacturing --- biopharmaceutical manufacturing --- process modeling --- mixed-integer linear programming --- bin-packing problem --- material requirements planning --- agri-supply chain management --- variable production rate --- optimal resources --- imperfect production --- eco-efficient production --- closed-loop scheduling --- scheduling stability --- optimal control and scheduling --- fouling --- heat exchanger networks --- continuous manufacturing --- bioprocessing --- process systems engineering --- single-use technology --- AGV-Automated Guided Vehicles --- DES-Discrete Event Simulation --- FMS-Flexible Manufacturing Systems --- OEE-Overall Equipment Efficiency --- WCLcWorld Class Logistic --- abrasive water jet --- cutting --- surface quality --- quality prediction --- 3D simulation modeling and analysis --- model implementation --- bottleneck analysis --- production costs --- resource conservation --- smart manufacturing --- edge computing --- machine learning --- blockchain --- Industrial Internet of Things --- inventory management --- supply chain --- multi-echelon --- stochastic programming --- reinforcement learning --- digitalisation --- model-based --- computational engineering --- process simulation --- LNG terminal --- operational optimization --- BOG compressor --- MINLP --- enterprise process architecture --- new technologies integration --- process intelligence --- real-time monitoring --- fault detection --- predictive process adjustment --- vacuum gripper --- sensor data --- Tri-X Intelligence --- cyber-physical systems --- human-cyber systems --- intelligent systems --- intelligent manufacturing --- multi-parametric programming --- explicit MPC --- enterprise-wide optimisation --- set-point tracking --- algebraic geometry --- continuous pharmaceutical manufacturing --- model predictive control --- state estimation --- quality-by-control (QbC) --- glidant effects --- plant-model mismatch --- regional logistics --- low-carbon economy --- cloud model --- comprehensive evaluation --- Beijing-Tianjin-Hebei region --- pharmaceutical manufacture --- uncertainty --- operational flexibility --- operational envelopes --- modeling --- manufacturing process --- additive manufacturing --- IoT --- computer systems and networks --- 3D printing --- digital twin --- Industry 4.0 --- pharmaceutical manufacturing --- biopharmaceutical manufacturing --- process modeling --- mixed-integer linear programming --- bin-packing problem --- material requirements planning --- agri-supply chain management --- variable production rate --- optimal resources --- imperfect production --- eco-efficient production --- closed-loop scheduling --- scheduling stability --- optimal control and scheduling --- fouling --- heat exchanger networks --- continuous manufacturing --- bioprocessing --- process systems engineering --- single-use technology --- AGV-Automated Guided Vehicles --- DES-Discrete Event Simulation --- FMS-Flexible Manufacturing Systems --- OEE-Overall Equipment Efficiency --- WCLcWorld Class Logistic --- abrasive water jet --- cutting --- surface quality --- quality prediction --- 3D simulation modeling and analysis --- model implementation --- bottleneck analysis --- production costs --- resource conservation --- smart manufacturing --- edge computing --- machine learning --- blockchain --- Industrial Internet of Things --- inventory management --- supply chain --- multi-echelon --- stochastic programming --- reinforcement learning --- digitalisation --- model-based --- computational engineering --- process simulation --- LNG terminal --- operational optimization --- BOG compressor --- MINLP --- enterprise process architecture --- new technologies integration --- process intelligence --- real-time monitoring --- fault detection --- predictive process adjustment --- vacuum gripper --- sensor data --- Tri-X Intelligence --- cyber-physical systems --- human-cyber systems --- intelligent systems --- intelligent manufacturing --- multi-parametric programming --- explicit MPC --- enterprise-wide optimisation --- set-point tracking --- algebraic geometry --- continuous pharmaceutical manufacturing --- model predictive control --- state estimation --- quality-by-control (QbC) --- glidant effects --- plant-model mismatch --- regional logistics --- low-carbon economy --- cloud model --- comprehensive evaluation --- Beijing-Tianjin-Hebei region --- pharmaceutical manufacture --- uncertainty --- operational flexibility --- operational envelopes --- modeling