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The worldwide emergence of antimicrobial-resistant bacteria, specially those resistant to last-resource antibiotics, is now a common problem being defined as one of three priorities for the safeguarding of One Health by the Tripartite Alliance, which includes the World Health Organization (WHO), the Food and Agriculture Organization (FAO) and the Office International des Epizooties (OIE). Bacteria resistance profiles, together with the expression of specific virulence markers, have a major influence on the outcomes of infectious diseases. These bacterial traits are interconnected, since not only the presence of antibiotics may influence bacterial virulence gene expression and consequently infection pathogenesis, but some virulence factors may also contribute to an increased bacterial resistance ability, as observed in biofilm-producing strains. The surveillance of important resistant and virulent clones and associated mobile genetic elements is essential for decision making in terms of mitigation measures to be applied for the prevention of such infections in both human and veterinary medicine. However, the role of natural environments as important components of the dissemination cycle of these strains has not been consider until recently. This Special Issue aims to publish manuscripts that contribute to the understanding of the impact of bacterial antimicrobial resistance and virulence in the three areas of the One Health triad–i.e., animal, human and environmental health.

Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- MRSA --- EMRSA-15 --- MLSB --- bacteremia --- bloodstream infections --- antibiotic resistance --- aquatic contamination --- probabilistic sampling --- San Francisco Estuary --- coast --- Pseudomonas --- Shewanella algae --- Vibrio parahaemolyticus --- biocide --- Listeria monocytogenes --- biofilm --- planktonic culture --- pulsed-field gel electrophoresis --- Escherichia coli --- fosfomycin --- nitrofurantoin --- antimicrobial resistance --- antibiotic susceptibility --- WGS --- phylogenetic analysis --- DNA mismatch repair system --- Salmonella Choleraesuis --- Iberian pig --- wild boar --- phylogenetic relationship --- plasmid replicon typing --- colistin --- carcass --- cfr gene --- fexA gene --- linezolid --- mutation --- pig --- public health --- S. aureus --- avian colibacillosis --- salmonellosis --- MDR --- tetA --- nisin --- mutant prevention concentration --- mutant selection window --- antimicrobial susceptibility testing --- horizontal gene transfer --- Salmonella --- reptiles --- isolation --- biofilms --- chlorhexidine gluconate --- wounds --- Gram-negative bacteria --- colonization --- infection --- clonal lineages --- resistance genes --- virulence factors --- Staphylococcus aureus --- skin and soft-tissue infections --- plasmids --- Panton–Valentine leucocidin --- MRSA --- EMRSA-15 --- MLSB --- bacteremia --- bloodstream infections --- antibiotic resistance --- aquatic contamination --- probabilistic sampling --- San Francisco Estuary --- coast --- Pseudomonas --- Shewanella algae --- Vibrio parahaemolyticus --- biocide --- Listeria monocytogenes --- biofilm --- planktonic culture --- pulsed-field gel electrophoresis --- Escherichia coli --- fosfomycin --- nitrofurantoin --- antimicrobial resistance --- antibiotic susceptibility --- WGS --- phylogenetic analysis --- DNA mismatch repair system --- Salmonella Choleraesuis --- Iberian pig --- wild boar --- phylogenetic relationship --- plasmid replicon typing --- colistin --- carcass --- cfr gene --- fexA gene --- linezolid --- mutation --- pig --- public health --- S. aureus --- avian colibacillosis --- salmonellosis --- MDR --- tetA --- nisin --- mutant prevention concentration --- mutant selection window --- antimicrobial susceptibility testing --- horizontal gene transfer --- Salmonella --- reptiles --- isolation --- biofilms --- chlorhexidine gluconate --- wounds --- Gram-negative bacteria --- colonization --- infection --- clonal lineages --- resistance genes --- virulence factors --- Staphylococcus aureus --- skin and soft-tissue infections --- plasmids --- Panton–Valentine leucocidin

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Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice.In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs.

Medicine --- quantum dots (QDs) --- DNAzyme --- ROS --- Amplex Red --- light-induced activity --- DNA methylation --- histone code --- microRNA --- nanoparticles --- noncoding RNA --- pulmonary arterial hypertension --- aptamer --- aptasensor --- influenza --- SERS --- virus detection --- α-synuclein --- antisense oligonucleotide --- dopamine neurotransmission --- double mutant A30P*A53T* --- motor deficits --- Parkinson’s disease --- transgenic mouse model --- G-quadruplexes --- covalent dimer construct --- anti-proliferative activity --- primary cell culture of human glioma --- antisensense oligonucleotide --- Foxp3 --- regulatory T cells --- vaccine immunogenicity --- Sporothrix schenckii --- Marfan syndrome --- fibrillin-1 --- antisense oligonucleotides --- exon skipping --- splice-switching --- quantum dots (QDs) --- DNAzyme --- ROS --- Amplex Red --- light-induced activity --- DNA methylation --- histone code --- microRNA --- nanoparticles --- noncoding RNA --- pulmonary arterial hypertension --- aptamer --- aptasensor --- influenza --- SERS --- virus detection --- α-synuclein --- antisense oligonucleotide --- dopamine neurotransmission --- double mutant A30P*A53T* --- motor deficits --- Parkinson’s disease --- transgenic mouse model --- G-quadruplexes --- covalent dimer construct --- anti-proliferative activity --- primary cell culture of human glioma --- antisensense oligonucleotide --- Foxp3 --- regulatory T cells --- vaccine immunogenicity --- Sporothrix schenckii --- Marfan syndrome --- fibrillin-1 --- antisense oligonucleotides --- exon skipping --- splice-switching

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Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice.In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs.

quantum dots (QDs) --- DNAzyme --- ROS --- Amplex Red --- light-induced activity --- DNA methylation --- histone code --- microRNA --- nanoparticles --- noncoding RNA --- pulmonary arterial hypertension --- aptamer --- aptasensor --- influenza --- SERS --- virus detection --- α-synuclein --- antisense oligonucleotide --- dopamine neurotransmission --- double mutant A30P*A53T* --- motor deficits --- Parkinson’s disease --- transgenic mouse model --- G-quadruplexes --- covalent dimer construct --- anti-proliferative activity --- primary cell culture of human glioma --- antisensense oligonucleotide --- Foxp3 --- regulatory T cells --- vaccine immunogenicity --- Sporothrix schenckii --- Marfan syndrome --- fibrillin-1 --- antisense oligonucleotides --- exon skipping --- splice-switching

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Herbal and plant extracts show diverse activities and have been used for centuries as natural medicines for many health problems and diseases. Through the isolation and analysis of the compounds in the extracts, it is possible to understand why the extracts exhibit those activities, as well as the chemical metabolism of compounds that occur in plants and herbs. Recently, there have been increasing attempts to develop herbal and plant extracts into functional foods and drugs, but the legal requirements are becoming stricter. We need sophisticatedly defined extracts through the isolation and analysis of compounds comprising them in order to meet the legal requirements and to pursue quality control strategies in the production of functional foods and drugs. This Special Issue Book compiled the 15 recent research and review articles that highlight the isolation, profiling, and analysis of compounds in herbal and plant extracts, as well as quality control and standardized processing strategies for extracts with characteristic compounds.

Polygala tenuifolia --- phenolic glycosides --- saponins --- anti-inflammatory effect --- bioactive compound --- isatidis folium --- HPLC-PDA-ESI-MS/MS --- antiwrinkle activity --- quality control --- response surface methodology --- Boesenbergia rotunda --- Zingiberaceae --- flavonoid --- 4-hydroxypanduratin --- vasorelaxation --- tribe Clauseneae --- DNA barcode --- volatile compounds --- antioxidant activity --- ACE inhibitory activity --- anticancer activity --- α-glucosidase inhibitory activity --- avocado oil --- fatty acids --- hearing loss --- zebrafish --- hair cell --- Schisandra chinensis --- Omija --- dibenzocyclooctadiene lignans --- seed --- flower --- fermented beverage --- dried tepals --- total phenolic content --- total anthocyanin content --- vitamin C --- ultrasound assisted extraction --- biorefining --- fibrosarcoma --- metastasis --- natural products --- plants --- protease inhibitors --- tumor cells --- bombacoideae --- pharmacology --- phytochemical ingredients --- bioactive compounds --- medicine --- Hippophae rhamnoides --- Elaeagnaceae --- citrate derivatives --- nuclear magnetic resonance (NMR) --- electronic circular dichroism (ECD) --- Dendrobium --- Orchidaceae --- D. nobile --- D. candidum --- D. nobile × candidum --- gamma-irradiated mutant --- metabolomics --- cytotoxicity --- Morus sp. pl. --- cultivar --- mulberry --- 1-DNJ --- HPLC-ESI-MS --- HILIC --- Inonotus obliquus --- inotodiol --- noncompartment analysis --- pharmacokinetic study --- Coreopsis rosea --- Coreopsis verticillata --- mutant cultivar --- dipeptidyl peptidase-IV --- analytical tools --- data analysis --- genetically modified crops --- mass spectrometry --- metabolomics databases --- metabolomics software tools --- omics --- plant biology --- n/a

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This book—entitled “Mechanisms and Novel Therapeutic Approaches for Gynecologic Cancer”—was edited as a Special Issue of Biomedicines, focusing on basic research such as genomics, epigenomics, and proteomics, as well as clinical research in the field of gynecologic oncology. The number of patients with gynecological cancer has been increasing worldwide due to its high lethality and lack of early detection tools and effective therapeutic interventions. In this regard, basic research on its pathophysiology and novel molecular targeting intervention is required to improve the prognosis of gynecologic cancer. This book contains 13 papers, including 8 original research papers and 5 reviews focusing on the basic research of gynecologic oncology. The reader can learn about state-of-the-art research and obtain extensive knowledge of the current advances in the field of gynecologic oncology. It is my hope that this book contributes towards the progress of gynecologic oncology.

Public health & preventive medicine --- nucleus accumbens-associated protein 1 (NAC1) --- BEN (BANP, E5R and NAC1) domain --- sequence-specific DNA-binding protein --- solution NMR structure --- isothermal titration calorimetry (ITC) --- human cytomegalovirus --- ovarian cancer --- cancer progression --- inflammation --- immunosuppression --- endometrial carcinoma --- immune micro-environment --- immune checkpoints inhibitors --- microsatellite instability --- mismatch repair deficiency --- platelet-activating factor acetylhydrolase (PAF-AH --- PLA2G7) --- BRCA1 mutant ovarian cancer --- Wnt signaling --- pGSK3β --- β-catenin --- prognosis --- vulvar melanoma --- vaginal melanoma --- targeted therapy --- gynecological cancer --- melanoma treatment --- gene ontology --- epithelial ovarian cancers --- borderline ovarian tumors --- differentially expressed genes --- aryl hydrocarbon receptor --- epithelial-mesenchymal transition --- integrative analysis --- testin --- p16 protein --- cervical cancer --- cervical neoplasia --- immunohistochemistry --- chimeric antigen receptor --- CD44 --- adoptive immunotherapy --- NK cells --- epithelial ovarian cancer --- DNA damage response --- somatic mutation --- clear cell carcinoma --- endometrioid endometrial cancer --- DNA mismatch repair (MMR) --- MMR deficient (dMMR) --- long-term survival --- exosome --- miRNA --- biomarkers --- liquid biopsy --- interventional radiotherapy --- vaginal-cuff brachytherapy --- HDR brachytherapy --- in vivo dosimetry --- endometrial cancer --- biological planning --- drug repurposing --- non-coding RNAs --- nanocarriers --- anti-angiogenic therapy --- nucleus accumbens-associated protein 1 (NAC1) --- BEN (BANP, E5R and NAC1) domain --- sequence-specific DNA-binding protein --- solution NMR structure --- isothermal titration calorimetry (ITC) --- human cytomegalovirus --- ovarian cancer --- cancer progression --- inflammation --- immunosuppression --- endometrial carcinoma --- immune micro-environment --- immune checkpoints inhibitors --- microsatellite instability --- mismatch repair deficiency --- platelet-activating factor acetylhydrolase (PAF-AH --- PLA2G7) --- BRCA1 mutant ovarian cancer --- Wnt signaling --- pGSK3β --- β-catenin --- prognosis --- vulvar melanoma --- vaginal melanoma --- targeted therapy --- gynecological cancer --- melanoma treatment --- gene ontology --- epithelial ovarian cancers --- borderline ovarian tumors --- differentially expressed genes --- aryl hydrocarbon receptor --- epithelial-mesenchymal transition --- integrative analysis --- testin --- p16 protein --- cervical cancer --- cervical neoplasia --- immunohistochemistry --- chimeric antigen receptor --- CD44 --- adoptive immunotherapy --- NK cells --- epithelial ovarian cancer --- DNA damage response --- somatic mutation --- clear cell carcinoma --- endometrioid endometrial cancer --- DNA mismatch repair (MMR) --- MMR deficient (dMMR) --- long-term survival --- exosome --- miRNA --- biomarkers --- liquid biopsy --- interventional radiotherapy --- vaginal-cuff brachytherapy --- HDR brachytherapy --- in vivo dosimetry --- endometrial cancer --- biological planning --- drug repurposing --- non-coding RNAs --- nanocarriers --- anti-angiogenic therapy