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Dear colleagues, This Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches”, focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions. Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. Chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment. The pathophysiology of endothelial dysfunction (ED) is complex and multi-factorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions, as well as the early detection of or molecular imaging techniques for endothelial dysfunction, helps to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had promising beneficial effects in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host–immune reactions near tumor environments.

Technology: general issues --- Biotechnology --- endothelial cells --- oxidative stress --- inflammageing --- endothelial dysfunction --- aldehyde dehydrogenase-2 --- cardiovascular disease --- neurovascular disease --- vascular inflammation --- APE1/Ref-1 --- cardiovascular diseases --- subcellular localization --- serological biomarkers --- atherosclerosis --- aerobic exercise --- PCSK9 --- LOX-1 --- insulin resistance --- macrophage polarity --- serum γ-glutamyltransferase --- essential hypertension --- cardiovascular risk factors --- angiogenesis --- nargenicin A1 --- compound 9 --- VEGF --- VEGFR2 --- HIF-1α --- electronegative low-density lipoprotein --- LDL(–) --- L5 LDL --- oxidized LDL --- oxLDL --- ADMA --- arginine --- arginine paradox --- BH4 --- blood pressure --- COVID-19 --- dietary supplements --- endothelium --- eNOS uncoupling --- heart failure --- hypertension --- L-arginine --- myocardial infarction --- NADPH --- nitric oxide --- peripheral artery disease --- ApoE knockout mouse --- atorvastatin --- VCAM-1 --- galectin-3 --- neutrophil/lymphocyte ratio --- electronegative LDL --- LDL(−) --- lectin-like oxLDL receptor-1 --- dyslipidemia --- chronic venous insufficiency --- prolyl oligopeptidase (POP) --- inflammation --- endothelial disfunction --- lung disease --- endothelial to mesenchymal transition --- pulmonary hypertension --- pulmonary fibrosis --- metformin --- diabetes --- CV risk --- hyperglycemia --- glycated lipoproteins --- glycated LDL --- glycated HDL --- endothelial cell dysfunction --- molecular mechanisms --- epigenetic factors --- therapeutic approaches --- vasoactive factors --- EndoMT --- TGF-β --- epigenetics --- endothelial cell --- glycolysis --- metabolism --- pathological angiogenesis --- tumor microenvironment --- MRI (magnetic resonance imaging) --- high-fat diets --- plaque burden --- low-level laser therapy --- phototherapy --- vascular disease --- healing --- ischemia --- vascular calcification --- chronic kidney disease --- CKD --- uremic toxins --- hyperphosphatemia --- vascular smooth muscle cells --- VSMCs --- macrophages --- n/a --- LDL(-)

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Dear colleagues, This Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches”, focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions. Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. Chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment. The pathophysiology of endothelial dysfunction (ED) is complex and multi-factorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions, as well as the early detection of or molecular imaging techniques for endothelial dysfunction, helps to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had promising beneficial effects in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host–immune reactions near tumor environments.

Technology: general issues --- Biotechnology --- endothelial cells --- oxidative stress --- inflammageing --- endothelial dysfunction --- aldehyde dehydrogenase-2 --- cardiovascular disease --- neurovascular disease --- vascular inflammation --- APE1/Ref-1 --- cardiovascular diseases --- subcellular localization --- serological biomarkers --- atherosclerosis --- aerobic exercise --- PCSK9 --- LOX-1 --- insulin resistance --- macrophage polarity --- serum γ-glutamyltransferase --- essential hypertension --- cardiovascular risk factors --- angiogenesis --- nargenicin A1 --- compound 9 --- VEGF --- VEGFR2 --- HIF-1α --- electronegative low-density lipoprotein --- LDL(-) --- L5 LDL --- oxidized LDL --- oxLDL --- ADMA --- arginine --- arginine paradox --- BH4 --- blood pressure --- COVID-19 --- dietary supplements --- endothelium --- eNOS uncoupling --- heart failure --- hypertension --- L-arginine --- myocardial infarction --- NADPH --- nitric oxide --- peripheral artery disease --- ApoE knockout mouse --- atorvastatin --- VCAM-1 --- galectin-3 --- neutrophil/lymphocyte ratio --- electronegative LDL --- LDL(−) --- lectin-like oxLDL receptor-1 --- dyslipidemia --- chronic venous insufficiency --- prolyl oligopeptidase (POP) --- inflammation --- endothelial disfunction --- lung disease --- endothelial to mesenchymal transition --- pulmonary hypertension --- pulmonary fibrosis --- metformin --- diabetes --- CV risk --- hyperglycemia --- glycated lipoproteins --- glycated LDL --- glycated HDL --- endothelial cell dysfunction --- molecular mechanisms --- epigenetic factors --- therapeutic approaches --- vasoactive factors --- EndoMT --- TGF-β --- epigenetics --- endothelial cell --- glycolysis --- metabolism --- pathological angiogenesis --- tumor microenvironment --- MRI (magnetic resonance imaging) --- high-fat diets --- plaque burden --- low-level laser therapy --- phototherapy --- vascular disease --- healing --- ischemia --- vascular calcification --- chronic kidney disease --- CKD --- uremic toxins --- hyperphosphatemia --- vascular smooth muscle cells --- VSMCs --- macrophages --- endothelial cells --- oxidative stress --- inflammageing --- endothelial dysfunction --- aldehyde dehydrogenase-2 --- cardiovascular disease --- neurovascular disease --- vascular inflammation --- APE1/Ref-1 --- cardiovascular diseases --- subcellular localization --- serological biomarkers --- atherosclerosis --- aerobic exercise --- PCSK9 --- LOX-1 --- insulin resistance --- macrophage polarity --- serum γ-glutamyltransferase --- essential hypertension --- cardiovascular risk factors --- angiogenesis --- nargenicin A1 --- compound 9 --- VEGF --- VEGFR2 --- HIF-1α --- electronegative low-density lipoprotein --- LDL(-) --- L5 LDL --- oxidized LDL --- oxLDL --- ADMA --- arginine --- arginine paradox --- BH4 --- blood pressure --- COVID-19 --- dietary supplements --- endothelium --- eNOS uncoupling --- heart failure --- hypertension --- L-arginine --- myocardial infarction --- NADPH --- nitric oxide --- peripheral artery disease --- ApoE knockout mouse --- atorvastatin --- VCAM-1 --- galectin-3 --- neutrophil/lymphocyte ratio --- electronegative LDL --- LDL(−) --- lectin-like oxLDL receptor-1 --- dyslipidemia --- chronic venous insufficiency --- prolyl oligopeptidase (POP) --- inflammation --- endothelial disfunction --- lung disease --- endothelial to mesenchymal transition --- pulmonary hypertension --- pulmonary fibrosis --- metformin --- diabetes --- CV risk --- hyperglycemia --- glycated lipoproteins --- glycated LDL --- glycated HDL --- endothelial cell dysfunction --- molecular mechanisms --- epigenetic factors --- therapeutic approaches --- vasoactive factors --- EndoMT --- TGF-β --- epigenetics --- endothelial cell --- glycolysis --- metabolism --- pathological angiogenesis --- tumor microenvironment --- MRI (magnetic resonance imaging) --- high-fat diets --- plaque burden --- low-level laser therapy --- phototherapy --- vascular disease --- healing --- ischemia --- vascular calcification --- chronic kidney disease --- CKD --- uremic toxins --- hyperphosphatemia --- vascular smooth muscle cells --- VSMCs --- macrophages

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The first national conference with international participation, “Fundamental aspects of atherosclerosis: scientific research for improving the technologies of personalized medicine”, was held in Novosibirsk on 15 October, 2021. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of atherosclerosis among various relevant specialists. The conference was intended for practicing cardiologists, primary care physicians, medical geneticists, and physician–scientists. The conference included plenary sessions, specialty sessions, satellite symposia, an open competition for young scientists.

Medicine --- Cardiovascular medicine --- metalloproteinases --- calcification --- atherosclerosis --- multiplex assay --- coronary heart disease --- aspirin --- resistance --- non-sensitivity --- antiplatelet --- light transmission aggregometry --- Plateletworks® --- familial hypercholesterolemia --- targeted sequencing technologies --- multiplex ligation-dependent probe amplification --- LDLR --- APOB --- ABCG5 --- APOC3 --- LPL --- SREBF1 --- rare variants --- coronary atherosclerosis --- ischemic heart disease --- saturated fatty acids --- monounsaturated fatty acids --- polyunsaturated fatty acids --- oxidative stress --- superoxide dismutase --- catalase --- glutathione peroxidase --- cumulative LDL-C level --- prognosis --- DNA methylation --- epigenetic age --- myocardial infarction --- acute coronary syndrome --- population --- nested case-control --- HAPIEE project --- HAPIEE study --- atrial fibrillation --- arterial hypertension --- obesity --- diabetes mellitus --- aging --- determinants --- prevalence --- Russian population cohort --- Cox regression analysis --- adiponectin --- leptin --- interleukin-6 --- epicardial adipose tissue --- perivascular adipose tissue --- circulating biochemical markers --- coronary atherosclerosis presence and severity --- integrated biomarker (i-BIO) --- validation --- visual markers --- lipoprotein(a) --- immune cells blood count --- metalloproteinases --- calcification --- atherosclerosis --- multiplex assay --- coronary heart disease --- aspirin --- resistance --- non-sensitivity --- antiplatelet --- light transmission aggregometry --- Plateletworks® --- familial hypercholesterolemia --- targeted sequencing technologies --- multiplex ligation-dependent probe amplification --- LDLR --- APOB --- ABCG5 --- APOC3 --- LPL --- SREBF1 --- rare variants --- coronary atherosclerosis --- ischemic heart disease --- saturated fatty acids --- monounsaturated fatty acids --- polyunsaturated fatty acids --- oxidative stress --- superoxide dismutase --- catalase --- glutathione peroxidase --- cumulative LDL-C level --- prognosis --- DNA methylation --- epigenetic age --- myocardial infarction --- acute coronary syndrome --- population --- nested case-control --- HAPIEE project --- HAPIEE study --- atrial fibrillation --- arterial hypertension --- obesity --- diabetes mellitus --- aging --- determinants --- prevalence --- Russian population cohort --- Cox regression analysis --- adiponectin --- leptin --- interleukin-6 --- epicardial adipose tissue --- perivascular adipose tissue --- circulating biochemical markers --- coronary atherosclerosis presence and severity --- integrated biomarker (i-BIO) --- validation --- visual markers --- lipoprotein(a) --- immune cells blood count

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The first national conference with international participation, “Fundamental aspects of atherosclerosis: scientific research for improving the technologies of personalized medicine”, was held in Novosibirsk on 15 October, 2021. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of atherosclerosis among various relevant specialists. The conference was intended for practicing cardiologists, primary care physicians, medical geneticists, and physician–scientists. The conference included plenary sessions, specialty sessions, satellite symposia, an open competition for young scientists.

Medicine --- Cardiovascular medicine --- metalloproteinases --- calcification --- atherosclerosis --- multiplex assay --- coronary heart disease --- aspirin --- resistance --- non-sensitivity --- antiplatelet --- light transmission aggregometry --- Plateletworks® --- familial hypercholesterolemia --- targeted sequencing technologies --- multiplex ligation-dependent probe amplification --- LDLR --- APOB --- ABCG5 --- APOC3 --- LPL --- SREBF1 --- rare variants --- coronary atherosclerosis --- ischemic heart disease --- saturated fatty acids --- monounsaturated fatty acids --- polyunsaturated fatty acids --- oxidative stress --- superoxide dismutase --- catalase --- glutathione peroxidase --- cumulative LDL-C level --- prognosis --- DNA methylation --- epigenetic age --- myocardial infarction --- acute coronary syndrome --- population --- nested case-control --- HAPIEE project --- HAPIEE study --- atrial fibrillation --- arterial hypertension --- obesity --- diabetes mellitus --- aging --- determinants --- prevalence --- Russian population cohort --- Cox regression analysis --- adiponectin --- leptin --- interleukin-6 --- epicardial adipose tissue --- perivascular adipose tissue --- circulating biochemical markers --- coronary atherosclerosis presence and severity --- integrated biomarker (i-BIO) --- validation --- visual markers --- lipoprotein(a) --- immune cells blood count --- n/a

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There have been recent significant improvements in the short-term survival of solid organ transplantation patients due to advances in immunosuppression and transplant techniques. However, long-term graft survival has still lagged behind other outcomes and has now become one of the main problems in solid organ transplantation.For this Special Issue, we invited researchers and clinicians to submit studies on solid organ transplantation. These have provided us with additional knowledge and skills that will ultimately help us to improve outcomes after solid organ transplantation.

living donation --- nephrectomy --- hand-assisted laparoscopic nephrectomy --- body composition --- complications --- simultaneous pancreas-kidney transplantation --- immunosuppression --- graft order --- sequence --- outcome --- survival --- kidney transplantation --- hydrogen --- diarrhea --- small intestinal bacterial overgrowth --- sickle cell disease --- sickle cell --- transplantation --- outcomes --- big data --- tacrolimus --- metabolism --- C/D ratio --- cholesterol --- dyslipidemia --- LDL-C --- liver transplantation --- hematuria --- chronic kidney disease --- tocilizumab --- clazakizumab --- desensitization --- anti-HLA alloantibody --- post traumatic growth --- psychiatric morbidity --- network analysis --- ESAS --- MINI --- CPC --- DCPR --- distress --- demoralization --- alexithymia --- anxiety --- antibody-mediated rejection --- recurrent primary disease --- renal transplantation --- pancreas transplantation --- cold ischemia time --- delayed graft function --- Eurotransplant Senior Program --- end-stage renal disease --- intensive care unit --- bioimpedance analysis --- drug dosing --- lean body mass index --- pharmacokinetics --- tacrolimus C/D ratio --- mineral bone disorder --- parathyroidectomy --- parathyroid hormone --- osteoporosis --- bone fractures --- Contrast-enhanced ultrasound --- kidney perfusion --- kidney function --- kidney donation --- n/a