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Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to “personalized cancer medicine”. Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies.The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care.

Medicine --- Pharmacology --- neutrophil-to-lymphocyte ratio --- lymphocyte-to-monocyte ratio --- prognosis --- rectal cancer --- mesorectum --- sphincter preserving --- molecular oncology --- precision medicine --- colorectal cancer --- targeted therapy --- molecular profiling --- pancreatic cysts --- thermal liquid biopsy --- differential scanning calorimetry --- diagnosis --- generalized linear models --- gene signature --- mRNA expression --- VANGL1 --- FFPE --- neurotoxicity --- oxaliplatin --- chemotherapy-induced peripheral neuropathy --- biomarker --- genomics --- neuropathy --- FOLFOX --- FOLFIRINOX --- XELOX --- gastrointestinal cancer --- LAG-3 --- immune checkpoint --- colon cancer --- survival --- microsatellite instability --- immunotherapy --- neutrophil-to-lymphocyte ratio --- lymphocyte-to-monocyte ratio --- prognosis --- rectal cancer --- mesorectum --- sphincter preserving --- molecular oncology --- precision medicine --- colorectal cancer --- targeted therapy --- molecular profiling --- pancreatic cysts --- thermal liquid biopsy --- differential scanning calorimetry --- diagnosis --- generalized linear models --- gene signature --- mRNA expression --- VANGL1 --- FFPE --- neurotoxicity --- oxaliplatin --- chemotherapy-induced peripheral neuropathy --- biomarker --- genomics --- neuropathy --- FOLFOX --- FOLFIRINOX --- XELOX --- gastrointestinal cancer --- LAG-3 --- immune checkpoint --- colon cancer --- survival --- microsatellite instability --- immunotherapy

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Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to “personalized cancer medicine”. Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies.The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care.

neutrophil-to-lymphocyte ratio --- lymphocyte-to-monocyte ratio --- prognosis --- rectal cancer --- mesorectum --- sphincter preserving --- molecular oncology --- precision medicine --- colorectal cancer --- targeted therapy --- molecular profiling --- pancreatic cysts --- thermal liquid biopsy --- differential scanning calorimetry --- diagnosis --- generalized linear models --- gene signature --- mRNA expression --- VANGL1 --- FFPE --- neurotoxicity --- oxaliplatin --- chemotherapy-induced peripheral neuropathy --- biomarker --- genomics --- neuropathy --- FOLFOX --- FOLFIRINOX --- XELOX --- gastrointestinal cancer --- LAG-3 --- immune checkpoint --- colon cancer --- survival --- microsatellite instability --- immunotherapy --- n/a

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This Special Issue collects papers devoted to organic coatings based on polymers, graphene, and their combinations. These systems have great potentialities in the development of advanced materials for functional applications. In particular, graphene-based coatings on polymer substrates have interesting electrical characteristics, which are very sensible to the temperature and, therefore, they are very adequate for developing sensing materials and other types of functional materials.

Research & information: general --- Physics --- Si-containing diamond-like carbon film --- near-edge X-ray absorption fine structure --- dependence on the elemental composition --- graphene oxide --- green chemical reduction --- ascorbic acid --- reduced graphene oxide --- graphite nanoplatelet coatings --- low-density polyethylene --- differential scanning calorimetry --- dynamical-mechanical-thermal analyses --- thermoresistive properties --- optical-grade epoxy --- inorganic scintillator --- alkali metal halides --- adhesion --- interface --- Coulomb forces --- optical properties --- clinoptilolite --- impedimetric sensor --- surface conductivity --- apnea syndrome monitoring --- voltage drop --- microwave --- plasma-enhanced --- CVD --- nitrogen-doped --- graphene --- catalyst-less --- transfer-less --- synthesis --- n/a --- graphite platelet coatings --- thermal expansion coefficient --- phase transitions

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Cell membranes are complex structures able to contain the main elements of the cell and to protect them from the external surroundings, becoming the most fundamental interface in Biology. The main subject of this book is the study of the structure and characteristics of lipid membranes in a wide variety of environments, ranging from simple phospholipid membranes to complex systems including proteins, peptides, or oncogenes as well as the analysis of the interactions of the membrane components with small molecules and drugs. The scope of this book is to provide recent developments on membrane structure, composition and function by means of theoretical and experimental techniques, some of them combining computer simulations with available data obtained at the laboratory.This Special Issue aims to report brand new key contributions to the field and also to give an overview about the connection between experiments and computer simulations, addressing fundamental aspects and applied research in biological membranes, with particular attention paid to the applications of computer modeling and simulation to medicine.

peptide --- MD --- GUV --- LUV --- azo-amino acid --- KRas-4B --- mutation --- post-translational modification --- HVR --- anionic plasma membrane --- signaling --- cholesterol --- model membranes --- molecular dynamics --- calorimetry --- Schiff base --- imine --- benzimidazole --- 2,4-dihydroxybenzaldehyde --- neutron reflectometry --- X-ray reflectometry --- small-angle neutron scattering --- small-angle X-ray scattering --- molecular dynamics simulations --- scattering length density profile --- phospholipid membrane --- phosphatidylserine --- cancer cells --- MD simulation --- membrane permeability --- withaferin A --- withanone --- CAPE --- artepillin C --- membrane elasticity --- red blood cells --- hemodynamics --- hemorheology --- microfluidics --- benzothiadiazine derivatives --- drug design --- KCNE3 --- structural dynamics --- lipid bilayers --- molecular dynamics simulation --- membrane mimetic --- n/a

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Everybody has made use of grease in their daily lives. The word “grease” originates from the early Latin word “crassus,” meaning fat. For our purposes, in this Special Issue, we will be focusing on lubricating grease, for publication in the eponymous journal Lubricants. According to ASTM, lubricating grease may be defined as “a solid-to-semi-fluid product of dispersed thickening agents in a liquid lubricant”. Other functional ingredients, such anti-wear and extreme pressure additives, may be included, with the overall goal of inducing special properties/functionalities. Grease is a very complex lubricant. We have never had a Special Issue focusing on this key product, and lubricating greases are often underrepresented in the technical literature. In recent years, there has been significant progress in research on greases, ranging from the specific chemical formulation of greases for special applications to how grease interacts with various surfaces, tribological advances in grease properties, new techniques for grease property measurements, etc. Recently, greases have also been evolving, as they and play a key role in the lubrication of electric vehicles. We aim to select the top research avenues and papers worldwide related to lubricating greases to form this compilation. This Special Issue wishes to be the first of its kind, and we plan to make this an annual exercise, where our compendium aims to discuss the latest developments worldwide encompassing all areas related to greases.

Technology: general issues --- History of engineering & technology --- grease degradation --- contact angle --- yield stress --- shearing --- tribology properties --- grease consistency --- grease testing --- cone penetration --- rheometer testing --- grease --- tackiness --- adhesion --- four-ball tester --- heat dissipation --- speed ramp up --- ASTM D2596 --- grease weld load --- grease friction --- greases --- EVs --- hybrid vehicle --- driveline lubricant --- electrification --- thermal properties --- electromagnetic field --- noise, vibration and harshness (NVH) --- energy efficiency --- elastohydrodynamic lubrication --- isothermal --- non-Newtonian --- point contact --- grease lubrication --- Bauer's model --- pressure gradient --- equivalent viscosity --- hybrid bearings --- electric vehicles --- electric motors --- friction and wear --- bio-based grease --- film thickness --- friction measurements --- polyurea thickener --- PAO --- CNTs --- wear --- coefficient of friction --- tribological behavior --- fretting --- sliding --- lubricating grease --- heterogeneous crystallization --- glass transition --- rheology --- differential scanning calorimetry (DSC) --- grease degradation --- contact angle --- yield stress --- shearing --- tribology properties --- grease consistency --- grease testing --- cone penetration --- rheometer testing --- grease --- tackiness --- adhesion --- four-ball tester --- heat dissipation --- speed ramp up --- ASTM D2596 --- grease weld load --- grease friction --- greases --- EVs --- hybrid vehicle --- driveline lubricant --- electrification --- thermal properties --- electromagnetic field --- noise, vibration and harshness (NVH) --- energy efficiency --- elastohydrodynamic lubrication --- isothermal --- non-Newtonian --- point contact --- grease lubrication --- Bauer's model --- pressure gradient --- equivalent viscosity --- hybrid bearings --- electric vehicles --- electric motors --- friction and wear --- bio-based grease --- film thickness --- friction measurements --- polyurea thickener --- PAO --- CNTs --- wear --- coefficient of friction --- tribological behavior --- fretting --- sliding --- lubricating grease --- heterogeneous crystallization --- glass transition --- rheology --- differential scanning calorimetry (DSC)