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Tight junctions (Cell biology) --- Life sciences. --- Biosciences --- Sciences, Life --- Science --- Junctions, Tight (Cell biology) --- Pentilaminar junctions (Cell biology) --- Zonula occludens --- Cell junctions --- Junctional complexes (Epithelium)

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Dear Colleagues, A rare disease, also known as an orphan disease, is any disease that affects a small percentage of the population. Although definitions vary from continent to continent, according to the European Union, rare diseases are those with a prevalence of less than 1 in 2000 people. Rare diseases are, in general, chronic, debilitating diseases, which in many cases threaten patients’ lives. It is estimated that 1–2 million people in the European Union are affected by a rare respiratory disease, which is a public health problem. Due to the low prevalence and severity of many of these diseases, whose symptoms often initially manifest in childhood, combined efforts are needed to improve our knowledge of the pathophysiology of these diseases that will lead to the development of new, more effective treatments. Therefore, since rare respiratory diseases represent an important field in medicine, we propose this Special Issue to promote the dissemination of the latest advances in basic and clinical research in these diseases. Prof. Dr. Francisco Dasí Guest Editor

standard diagnosis --- reference centres --- clinical presentation --- cilia --- primary ciliary dyskinesia --- alpha-1 antitrypsin deficiency --- rare respiratory diseases --- Mycobacterium avium --- Mycobacterium intracellulare --- nodular bronchiectasis --- non-tuberculous mycobacteria --- pulmonary aspergillosis --- rare pulmonary disease --- miRNA expression --- exhaled breath condensate --- sputum --- severity --- pulmonary exacerbation --- alpha1 antitrypsin deficiency --- augmentation therapy --- replacement therapy --- rare diseases --- gene therapy --- alpha-1-antitrypsin deficit --- cystic fibrosis --- neonatal respiratory distress --- laterality defect --- orphan diseases --- PCD --- immunofluorescence --- antibody --- ALI culture --- bio-resource --- primary nasal epithelium --- diagnostics --- Alpha-1 antitrypsin deficiency --- liver disease --- glutamate-oxaloacetate transaminase --- glutamate-pyruvate transaminase --- gamma-glutamyl transpeptidase --- resilience --- active lifestyle --- stress levels --- infection control measure --- self-quarantine --- flow cytometry --- nasal epithelium --- oxidative stress --- reactive oxygen species --- endoplasmic reticulum stress --- antioxidant therapies --- idiopathic pulmonary fibrosis --- chronic obstructive pulmonary disease --- bronchiectasis --- asthma --- emphysema --- alpha1-antitrypsin deficiency --- transient elastography --- n/a

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This reprint collates papers from a Special Issue of the journal Antibiotics, which was entitled "Ocular surface Infection and Antimicrobials". The papers cover aspects such as common microbes which cause ocular infections and their susceptibility to antibiotics; how guidelines for antibiotic use can translate to improved patient compliance; how bacteria respond to antibiotics; and lastly, new treatments and ways of preventing ocular surface infections.

Bacteriology (non-medical) --- coagulase-negative staphylococci --- eye infections --- endophthalmitis --- keratitis --- conjunctivitis --- blepharitis --- API Staph --- Biolog --- DNA sequencing --- sodA gene --- antibiotic susceptibility --- bacterial infection --- Serratia marcescens --- transcription factor --- ocular surface --- epithelium --- cornea --- metabolomics --- ocular infection --- predatory bacteria --- Bdellovibrio --- Micavibrio --- Pseudomonas aeruginosa --- Enterobacterales --- infection --- bacteria --- stress response system --- antibiotic --- Staphylococcus aureus --- antibiotic resistance --- biofilms --- antimicrobial peptides --- ciprofloxacin --- combined effect --- microbial keratitis --- corneal infiltrative events --- MPDS susceptibility --- Staphyloccus aureus --- MSSA --- pulsed-field gel electrophoresis --- multilocus sequence typing --- Panton-Valentine leukocidin --- Mel4 peptide --- antimicrobial contact lens --- extended wear --- biocompatibility --- comfort --- clinical trail --- misuse of antibiotics --- orthokeratology --- contact lens --- questionnaire --- contact lenses --- ultraviolet C --- Pseudomonas --- Staphylococcus --- Fusarium --- Candida --- ocular infectious isolates --- whole genome sequencing --- virulence factors --- n/a

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Squamous cell cancer (SCC) development and recent preclinical and clinical advances for the effective prevention and treatment of the disease are covered in this book. Experts in the field describe here the cellular and molecular events in SCC development, recurrence, and metastasis, and provide an updated snapshot on our understanding of the heterogeneity of SCC pathogenesis with novel opportunities in precision therapeutics to achieve better clinical outcomes.

n/a --- oral cancer --- tobacco --- alcohol --- human papilloma virus --- targeted sequencing --- DNA copy number --- TP53 --- CDKN2A --- EGFR --- PIK3CA --- anal cancer --- radiation therapy --- chemoradiation --- de-escalation of therapy --- pain --- cathepsin S --- protease-activated receptor-2 --- PAR2 --- cancer pain --- oral squamous cell carcinoma --- differentiation --- terminal differentiation --- oral epithelium --- epithelial integrity --- epithelial transformation --- genetic alterations --- therapy response biomarkers --- cutaneous squamous cell carcinoma --- immunotherapy --- anti-PD1 --- biomarkers --- predictive medicine --- personalized medicine --- cancer --- immune system --- HNSCC --- farnesyl transferase --- tipifarnib --- combination regimen --- oropharynx --- neoplasm --- squamous cell carcinoma --- human papillomavirus --- therapeutic management --- treatment selection --- CSCC --- treatment --- advances --- biology --- immunocompromised --- immune checkpoint inhibition

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"We are, all of us, everywhere, always, enmeshed in a web of rules and constraints. Rules fix the beginning and end of the working day and the school year, direct the ebb and flow of traffic on the roads, dictate who can be married to whom and how, place the fork to the right or the left of the plate, lay down the meter and rhyme scheme of a Petrarchan sonnet, and order the rites of birth and death. Cultures notoriously differ as to the content of their rules, but there is no culture without rules. In this book, historian of science Lorraine Daston adopts a long term perspective for studying rules from diverse sources, including monastic orders, cookbooks, and mathematical algorithms. She argues that in the Western tradition most rules can be characterized as one of the following: tools of measurement and calculation, models or paradigms, or laws. Moreover, they exist on spectra from specific to general, flexible to rigid and the specific-to-general, and universal-to-particular. In investigating how rules work, how they don't work, how they've changed across time, and why exceptions are necessary, Daston paints a vivid picture of Western civilization from the antiquity to the present"--

Authority. --- Order (Philosophy) --- Algorithms. --- Law. --- Natural law. --- Order (Philosophy). --- General ethics --- World history --- Authority --- Algorithms --- Law --- Natural law --- Computer algorithms. --- Ethics. --- Actin. --- Algorithm. --- Analogy. --- Aphorism. --- Augustine of Hippo. --- Biotope. --- Braid. --- Brain. --- Brightness. --- Calculation. --- Casuistry. --- Cataclysm (Dragonlance). --- Catechism. --- Chapter 33 (G.I. Bill of Rights). --- Charles Babbage. --- Codification (law). --- Computer program. --- Consonant. --- Culprit. --- Cydnidae. --- Cytoplasmic incompatibility. --- Depiction. --- Designer. --- Dictionary. --- Discretion. --- Drosophila. --- Early Modern literature. --- Electricity. --- Electronics. --- Epithelium. --- Fertilisation. --- Fishing. --- Francis Bacon. --- Gamma ray. --- Genre. --- Good and evil. --- Gottfried Wilhelm Leibniz. --- Government debt. --- Gut flora. --- Hannah Glasse. --- Herder. --- His Family. --- Horntail. --- Household. --- Human intelligence (intelligence gathering). --- Human intelligence. --- Imitation. --- Indication (medicine). --- Insect. --- John Herschel. --- Kinase. --- Lactobacillus. --- Lipid. --- Lookup table. --- Mathematician. --- Mathematics. --- Measurement. --- Metabolism. --- Metabolite. --- Metaphysics. --- Microbiota. --- Microorganism. --- Miguel de Cervantes. --- Monochord. --- Nationalism. --- Natural philosophy. --- Obedience (human behavior). --- Organism. --- Parallel Lives. --- Parchment. --- Pathogen. --- Philosophy. --- Phonetics. --- Polykleitos. --- Precept. --- Prerogative. --- Public utility. --- Publishing. --- Reason. --- Result. --- Rule of Saint Benedict. --- Sect. --- Shavian alphabet. --- Shawl. --- Simon Stevin. --- Spelling rule. --- State of nature. --- Statute. --- Straightedge. --- Subtitle (captioning). --- Subtraction. --- Supplication. --- The Nautical Almanac. --- The Opposite Direction. --- Titer. --- Treatise. --- Tropical rainforest. --- Usage. --- Warfare.