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Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.

Medicine --- nonalcoholic fatty liver disease --- nonalcoholic steatohepatitis --- Fibrosis --- Liver biopsy --- Genomics --- Metabolomics --- Proteomics --- Transcriptomics --- nicotinamide --- NAFLD --- steatosis --- heat stress --- primary mouse hepatocytes --- metabolic profile --- GC-MS --- multivariate statistical analysis --- arachidonic acid --- docosahexaenoic acid --- inflammation --- fibrosis --- lipidomics --- mass spectrometry --- in vitro --- HepaRG --- sodium saccharin --- reference toxicants --- de novo lipogenesis --- carbohydrate response element-binding protein --- ChREBP --- diabetes --- glucose production --- glycogen --- glycolysis --- glycogen storage disease type I --- hexosamine --- pentose phosphate pathway --- acupuncture --- imflammation --- lipid metabolism --- oxidative stress --- metabolomics quantitative profiling --- 1H-NMR spectroscopy --- liver --- bile acids --- metabolomics --- rat plasma --- tandem mass spectrometry --- liquid chromatography --- acetaminophen --- hepatotoxicity --- biomarker --- premalignant --- alcoholic liver disease --- cholestasis --- cirrhosis --- NAFL --- NASH --- standard operating procedures --- urine --- blood --- feces --- tissue --- cells --- liver function --- nonalcoholic fatty liver --- liquid chromatography-mass spectrometry --- nuclear magnetic resonance spectroscopy --- metabolic pathway --- non-alcoholic fatty liver disease --- non-alcoholic steatohepatitis --- transcription factors --- metabolic stress --- lipid homeostasis --- glucose homeostasis

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Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.

Medicine --- nonalcoholic fatty liver disease --- nonalcoholic steatohepatitis --- Fibrosis --- Liver biopsy --- Genomics --- Metabolomics --- Proteomics --- Transcriptomics --- nicotinamide --- NAFLD --- steatosis --- heat stress --- primary mouse hepatocytes --- metabolic profile --- GC-MS --- multivariate statistical analysis --- arachidonic acid --- docosahexaenoic acid --- inflammation --- fibrosis --- lipidomics --- mass spectrometry --- in vitro --- HepaRG --- sodium saccharin --- reference toxicants --- de novo lipogenesis --- carbohydrate response element-binding protein --- ChREBP --- diabetes --- glucose production --- glycogen --- glycolysis --- glycogen storage disease type I --- hexosamine --- pentose phosphate pathway --- acupuncture --- imflammation --- lipid metabolism --- oxidative stress --- metabolomics quantitative profiling --- 1H-NMR spectroscopy --- liver --- bile acids --- metabolomics --- rat plasma --- tandem mass spectrometry --- liquid chromatography --- acetaminophen --- hepatotoxicity --- biomarker --- premalignant --- alcoholic liver disease --- cholestasis --- cirrhosis --- NAFL --- NASH --- standard operating procedures --- urine --- blood --- feces --- tissue --- cells --- liver function --- nonalcoholic fatty liver --- liquid chromatography-mass spectrometry --- nuclear magnetic resonance spectroscopy --- metabolic pathway --- non-alcoholic fatty liver disease --- non-alcoholic steatohepatitis --- transcription factors --- metabolic stress --- lipid homeostasis --- glucose homeostasis

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Increased consumer awareness of the effects of food in preventing nutrient-related diseases and maintaining physical and mental well-being has made nutritional improvement an important goal for the food and beverage industry, including the cereal sector. The Book “Qualitative and Nutritional Improvement of Cereal-Based Foods and Beverages” collects research articles aimed at exploring innovative ways to improve cereal-based foods and beverages; an old—if not ancient—group of products which are still on our table every day. The main directions of research aimed at nutritional improvement have to face either excess or deficiency in the diet. To this end, different strategies may be adopted, such as the reformulation of products, the introduction of functional ingredients, and the application of biotechnologies to increase the bioavailability of bioactive compounds. These interventions, however, can alter the physico-chemical and sensory properties of final products, making it necessary to achieve a balance between nutritional and quality modification. This book offers readers information on innovative ways to improve cereal-based foods and beverages, useful for researchers and for industry operators.

Research & information: general --- extruded products --- flaxseed --- amaranth --- dietary fiber --- extrusion-cooking --- fortified blended foods (FBFs) --- sensory --- food aid --- extrusion --- cereal --- legume --- infant --- child --- porridge --- sourdough --- fiber --- amino acids --- phenolic compounds --- phytic acid --- pulses --- re-milled semolina --- bread --- pizza --- focaccia --- rheological properties --- reofermentograph --- bioactive compounds --- texture --- sensory profile --- hemp --- chickpea --- milling by-products --- fortified pasta --- lactic acid bacteria --- nutritional value --- antioxidant capacity --- sensory properties --- functional foods --- pigmented wheat --- anthocyanins --- polyphenols --- alpha-amylase inhibition --- anti-inflammatory activity --- Moringa oleifera --- phenolic bioaccessibility --- starch digestion --- slowly digestible starch --- resistant starch --- Triticum turgidum L. subsp. durum Desf. --- NaCl --- low-sodium sea salt --- Na+ reduction --- physico-chemical and textural attributes --- sensory evaluation --- inulin --- bakery products --- xanthan gum --- leavening agent --- coffee silverskin --- chemical characterization --- toxicological analysis --- extreme vertices mixture design --- product development --- cereal beverage --- fermentation --- functional --- non-alcoholic --- health benefits --- wholewheat flour --- stone milling --- roller milling --- dough rheology --- djulis --- food quality --- optimization --- Taguchi grey relational analysis --- texture profile analysis --- sensory attributes --- protein energy malnutrition --- insect --- sorghum --- wheat --- cereal-based ready-to-drink beverage --- convenient meal replacement (CMR) --- germinated wheat --- response surface methodology (RSM) --- gamma-amino butyric acid (GABA) --- antioxidant properties --- almond skins --- by-product --- upcycling --- biscuits --- health claims --- nutritional composition --- Moringa oleifera leaf powder (MOLP) --- fortification --- consumer acceptability --- byproducts --- new quality --- insects --- pasta

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Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines --- n/a

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Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

Humanities --- Social interaction --- trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines