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Nutritional epidemiology examines dietary or nutritional factors in relation to the occurrence of disease in various populations. It is a fact that substantial progress has been made in recent years in nutritional epidemiology. Compared to the practice during the 1990s, and with the improvements in data analytics, several new approaches are gaining ground. Results from a variety of large-scale studies in the field of nutrition epidemiology have substantially contributed toward the evidence used in guiding dietary recommendations for the prevention of cardiovascular diseases, metabolic disorders, some types of cancer, and other morbidities. In this Special Issue, we would like to bring readers closer to the state-of-the-art in the field by gathering papers covering different aspects of nutrition epidemiology from population-based observational studies. Topics of the submitted articles may, but not necessarily, include eating habits of various populations, especially of those not well-studied, such as in Africa, Oceania, South Americas, immigrants, minorities, as well as a variety of associations between nutrients/foods/food patterns and chronic diseases, like cardiovascular, diabetes, obesity, cancer, etc., and gene–nutrient and epigenome–nutrient interactions related to human health at all ages.

Research & information: general --- Biology, life sciences --- Food & society --- healthy diet indexes --- food intake --- apulia --- mind index --- dash index --- med-diet score --- dietary patterns --- eating restrictions --- food involvement --- adults --- obesity --- nutrition assessment --- diet survey --- dietary pattern analysis --- nutrient inadequacy --- overweight and obesity --- nutritional epidemiology --- nutrition transition --- pastoral nomadism --- Mongolia --- central Asia --- breakfast consumption --- breakfast composition --- children --- dietary intake --- dietary quality --- diet patterns --- cardiometabolic outcomes --- adiposity --- short-chain fatty acids --- BMI --- waist-to-height ratio --- fiber --- gut metagenome --- diet --- plant sterols --- stanols --- omega-3 fatty acids --- familial hypercholesterolemia --- nutritional status --- population survey --- oral frailty --- health behavior --- eating competence --- health outcomes --- validation --- questionnaire --- food consumption --- salty snack products --- students --- consumption --- salt intake --- health policies --- nutrition policies --- Europe --- primary care --- breakfast intake --- lifestyle behaviors --- sociodemographic factors --- healthy diet indexes --- food intake --- apulia --- mind index --- dash index --- med-diet score --- dietary patterns --- eating restrictions --- food involvement --- adults --- obesity --- nutrition assessment --- diet survey --- dietary pattern analysis --- nutrient inadequacy --- overweight and obesity --- nutritional epidemiology --- nutrition transition --- pastoral nomadism --- Mongolia --- central Asia --- breakfast consumption --- breakfast composition --- children --- dietary intake --- dietary quality --- diet patterns --- cardiometabolic outcomes --- adiposity --- short-chain fatty acids --- BMI --- waist-to-height ratio --- fiber --- gut metagenome --- diet --- plant sterols --- stanols --- omega-3 fatty acids --- familial hypercholesterolemia --- nutritional status --- population survey --- oral frailty --- health behavior --- eating competence --- health outcomes --- validation --- questionnaire --- food consumption --- salty snack products --- students --- consumption --- salt intake --- health policies --- nutrition policies --- Europe --- primary care --- breakfast intake --- lifestyle behaviors --- sociodemographic factors

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Dyslipidemia, and particularly hypercholesterolemia, remains a main cardiovascular disease risk factor, partly reversible with the improvement of life-style, including dietary, habits. Even when a pharmacological treatment is begun, dietary support to lipid-lowering is always desired. This book will provide a selection of new evidence on the possible lipid-lowering effects of some dietary and medicinal plant components, reporting some interesting reviews, experimental data and results from clinical trials. The book is adapted for experts in nutrition but also for all scientists involved in cardiovascular disease prevention.

beta-glucan --- fiber --- lipid profile --- cholesterol --- intestinal function --- green tea --- epigallocatechin gallate --- chitosan --- microspheres --- Eudragit --- metabolic diseases --- LCD score --- CHNS --- dyslipidemia --- dietary factor --- plant based --- animal based --- Chinese adults --- nutraceuticals --- PCSK9 --- SREBP --- HNF1α --- berberine --- metabolic syndrome --- plant extracts --- natural antioxidant --- polyphenols --- bergamot --- blackcurrant --- liver steatosis --- ovariectomized --- phytoestrogen --- vitamin B12 --- healthy --- Saudi Arabia --- serum cholesterol --- serum triglycerides --- serum low density lipoprotein --- serum high density lipoprotein --- dietary intake --- lifestyle --- black raspberry --- excessive choline --- TMAO --- hypercholesterolemia --- hepatic inflammation --- review --- CVD --- cardiovascular health --- dietary fats --- dietary fiber --- phytosterols --- plant-based diet --- dietary pattern --- sustainability --- propolis --- formononetin --- gastric ulcer --- rats --- Chrysanthemum morifolium Ramat leaves --- obesity --- lipidomics --- liquid chromatography tandem mass spectrometry --- phospholipid --- sphingolipid --- monacolins --- LDL-cholesterol --- red yeast rice --- clinical trial --- endothelial function --- alpha-linolenic acid --- flaxseed --- lipids --- omega-3 --- walnuts --- type 2 diabetes mellitus --- glibenclamide --- omega-3 fatty acids --- high fat diet --- transcription factors --- streptozotocin --- Armolipid Plus® --- nutraceutical --- supplementation --- blood pressure --- fasting plasma glucose --- n/a

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Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function—in both the short- and long-term—is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.

inflammation --- chronic kidney disease --- anemia --- anemia of inflammation --- ESA hyporesponsiveness --- renal tubular epithelial cells --- macrophages --- lipocalin-2 --- iron --- cilastatin --- hypoxia inducible factor-1-α --- ischemia-reperfusion injury --- acute kidney injury --- cyclophilin A --- fibrosis --- renal fibrosis --- tubular necrosis --- preeclampsia --- podocytes --- VEGF --- FSGS --- proteinuria --- endocan --- ESM-1 --- renal replacement therapy --- kidney transplantation --- biomarker --- diabetic nephropathy --- focal segmental glomerulosclerosis --- innate immunity --- membranous nephropathy --- minimal change diseases --- TLR --- NOX1 --- ML171 --- reactive oxygen species --- ERK --- T cells --- glomerulonephritis --- chemokines --- renal disease --- DJ-1 --- ND-13 --- renal inflammation --- oxidative stress --- UUO --- autophagy --- apoptosis --- trehalose --- simvastatin --- endotoxin --- tubular apoptosis --- cytochrome C --- Bcl-XL --- survivin --- hypercholesterolemia --- xanthine oxidase --- NF-κB pathway --- tertiary lymphoid organs --- B cells --- BAFF --- kidney fibrosis --- myofibroblast activation --- extracellular matrix --- Hippo pathway --- verteporfin --- IgAN --- CKD --- progression --- ACEI --- corticosteroids --- costimulation --- coinhibition --- kidney transplant --- SPR --- protein binding affinity --- adaptive immunity --- epithelial-to-mesenchymal transition --- E. cava extracts --- dieckol --- spontaneously hypertensive rats --- angiotensin II --- n/a

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In this Special Issue, we have published papers on the health-promoting effects of nutraceuticals from different sources, and their effects in different pathologies. Extracts from plants have been analyzed, for example, extracts from olive leaves, Mikania micrantha, the devil’s claw, raspberries and others, alongside marine phytoplankton, egg-yolk and marketed dietary supplements. The effects of these extracts and dietary supplements have been studied in diseases associated with obesity, and in diseases where inflammation pathways are involved. The effectiveness of resveratrol and curcumin to support the anticancer activity of cisplatin has also been reported, as well as the ability of devil’s claw root extract to stimulate the CB2 receptors in synoviocytes in osteoarthritis patients. The anti-oxidant effect of marine phytoplankton has been studied on muscle damage, both in humans and in an animal model, and the effects of the metabolite of antocianin were analyzed in a mouse model of amyotrophic lateral sclerosis. Finally, reviews on the use of lactoferrin, ω3 and ω6 and abscisic acid have been reported, in addition to the crosstalk between prostate cancer and microbiota inflammation. Although it is not yet possible to draw definitive conclusions on the use of nutraceuticals, several mechanisms of action for many of them have been further clarified.

Humanities --- Social interaction --- fertility --- ingredients --- male reproduction --- semen parameters --- supplements --- allithiamine --- garlic --- hyperglycaemia --- advanced glycation end-products --- cytokines --- abscisic acid --- prediabetes --- type 2 diabetes mellitus --- metabolic syndrome --- insulin resistance --- adipocyte browning --- AMP-activated protein kinase --- food supplement --- frambinone --- meal frequency --- open-field test --- elevated plus maze --- sensory motor gating --- pre-pulse inhibition --- c-Fos --- amyotrophic lateral sclerosis --- anti-inflammatory --- antioxidant --- phenolic acid --- neuroprotective --- neurodegeneration --- obesity --- overweight --- beta-glucans --- chitosan --- follow up study --- weight loss programs --- weight gain --- weight loss --- body weight changes --- phytoplankton --- antioxidants --- muscle damage --- muscle recovery --- muscle soreness --- Viburnum opulus --- phenolic compounds --- adipogenesis --- PPARγ --- lipase inhibition --- green tea --- epigallocatechin --- lipid profile --- high-fat diet --- fast food --- osteoarthritis --- nutraceuticals --- polyphenols --- volatile compounds --- β-caryophyllene --- eugenol --- FAAH --- cannabinoid receptors --- phospholipases --- lactoferrin --- bovine milk --- nutraceutical --- human health --- resveratrol --- curcumin --- cisplatin --- head and neck cancer --- cell cycle --- apoptosis --- prostate cancer --- microbiota --- nutraceutical compounds --- fecundation --- inflammation --- cytokine --- growth factors --- metabolomics --- lipidomics --- ω-3PUFAs --- ω-6PUFAs --- endocannabinoids --- CRC --- fatty acids --- Gymnema inodorum --- gymnemic acid --- Mikania micrantha --- anti-hypercholesterolemia --- steatosis --- olive leaf --- macrophages --- fertility --- ingredients --- male reproduction --- semen parameters --- supplements --- allithiamine --- garlic --- hyperglycaemia --- advanced glycation end-products --- cytokines --- abscisic acid --- prediabetes --- type 2 diabetes mellitus --- metabolic syndrome --- insulin resistance --- adipocyte browning --- AMP-activated protein kinase --- food supplement --- frambinone --- meal frequency --- open-field test --- elevated plus maze --- sensory motor gating --- pre-pulse inhibition --- c-Fos --- amyotrophic lateral sclerosis --- anti-inflammatory --- antioxidant --- phenolic acid --- neuroprotective --- neurodegeneration --- obesity --- overweight --- beta-glucans --- chitosan --- follow up study --- weight loss programs --- weight gain --- weight loss --- body weight changes --- phytoplankton --- antioxidants --- muscle damage --- muscle recovery --- muscle soreness --- Viburnum opulus --- phenolic compounds --- adipogenesis --- PPARγ --- lipase inhibition --- green tea --- epigallocatechin --- lipid profile --- high-fat diet --- fast food --- osteoarthritis --- nutraceuticals --- polyphenols --- volatile compounds --- β-caryophyllene --- eugenol --- FAAH --- cannabinoid receptors --- phospholipases --- lactoferrin --- bovine milk --- nutraceutical --- human health --- resveratrol --- curcumin --- cisplatin --- head and neck cancer --- cell cycle --- apoptosis --- prostate cancer --- microbiota --- nutraceutical compounds --- fecundation --- inflammation --- cytokine --- growth factors --- metabolomics --- lipidomics --- ω-3PUFAs --- ω-6PUFAs --- endocannabinoids --- CRC --- fatty acids --- Gymnema inodorum --- gymnemic acid --- Mikania micrantha --- anti-hypercholesterolemia --- steatosis --- olive leaf --- macrophages

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• Reference Manager
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In this Special Issue, we have published papers on the health-promoting effects of nutraceuticals from different sources, and their effects in different pathologies. Extracts from plants have been analyzed, for example, extracts from olive leaves, Mikania micrantha, the devil’s claw, raspberries and others, alongside marine phytoplankton, egg-yolk and marketed dietary supplements. The effects of these extracts and dietary supplements have been studied in diseases associated with obesity, and in diseases where inflammation pathways are involved. The effectiveness of resveratrol and curcumin to support the anticancer activity of cisplatin has also been reported, as well as the ability of devil’s claw root extract to stimulate the CB2 receptors in synoviocytes in osteoarthritis patients. The anti-oxidant effect of marine phytoplankton has been studied on muscle damage, both in humans and in an animal model, and the effects of the metabolite of antocianin were analyzed in a mouse model of amyotrophic lateral sclerosis. Finally, reviews on the use of lactoferrin, ω3 and ω6 and abscisic acid have been reported, in addition to the crosstalk between prostate cancer and microbiota inflammation. Although it is not yet possible to draw definitive conclusions on the use of nutraceuticals, several mechanisms of action for many of them have been further clarified.

Humanities --- Social interaction --- fertility --- ingredients --- male reproduction --- semen parameters --- supplements --- allithiamine --- garlic --- hyperglycaemia --- advanced glycation end-products --- cytokines --- abscisic acid --- prediabetes --- type 2 diabetes mellitus --- metabolic syndrome --- insulin resistance --- adipocyte browning --- AMP-activated protein kinase --- food supplement --- frambinone --- meal frequency --- open-field test --- elevated plus maze --- sensory motor gating --- pre-pulse inhibition --- c-Fos --- amyotrophic lateral sclerosis --- anti-inflammatory --- antioxidant --- phenolic acid --- neuroprotective --- neurodegeneration --- obesity --- overweight --- beta-glucans --- chitosan --- follow up study --- weight loss programs --- weight gain --- weight loss --- body weight changes --- phytoplankton --- antioxidants --- muscle damage --- muscle recovery --- muscle soreness --- Viburnum opulus --- phenolic compounds --- adipogenesis --- PPARγ --- lipase inhibition --- green tea --- epigallocatechin --- lipid profile --- high-fat diet --- fast food --- osteoarthritis --- nutraceuticals --- polyphenols --- volatile compounds --- β-caryophyllene --- eugenol --- FAAH --- cannabinoid receptors --- phospholipases --- lactoferrin --- bovine milk --- nutraceutical --- human health --- resveratrol --- curcumin --- cisplatin --- head and neck cancer --- cell cycle --- apoptosis --- prostate cancer --- microbiota --- nutraceutical compounds --- fecundation --- inflammation --- cytokine --- growth factors --- metabolomics --- lipidomics --- ω-3PUFAs --- ω-6PUFAs --- endocannabinoids --- CRC --- fatty acids --- Gymnema inodorum --- gymnemic acid --- Mikania micrantha --- anti-hypercholesterolemia --- steatosis --- olive leaf --- macrophages