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Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials.

Research & information: general --- Chemistry --- serum half-life extension --- fatty acid conjugation --- FcRn-mediated recycling --- serum albumin --- translocator protein (TSPO) --- CoCl2 --- mitochondrial membrane potential --- reactive oxygen species (ROS) --- cell viability --- cell death --- lung cancer cell line --- acetylcholinesterase --- amyloid beta aggregation --- neuroprotection --- molecular docking --- multi-target drug --- structure–activity relationship --- brassicasterol --- phytosterols --- HSV --- Mycobacterium tuberculosis --- HSV-1 DNA polymerase --- HSV-1 TK --- human CDK2 --- ACE --- UDP-galactopyranose mutase --- heat shock protein 70 --- Hsp70 --- piperine --- fluorescence spectroscopy --- molecular dynamics --- molecular biophysics --- GADD45β --- MKK7 --- multiple myeloma --- protein-ligand interaction --- STD-NMR --- sigma receptors --- sigma ligands --- cancer --- SIGMAR1 --- PGRMC1 --- TMEM97 --- NCI60 COMPARE analysis --- membrane --- lipid-protein interaction --- lipid signalling --- kinase regulation --- phosphatidylinositols --- molecular docking simulation --- target identification --- small-molecule derivatives of salicylanilide --- drug discovery --- drug development --- thyroid diseases --- endocrine disruptor compound --- human umbilical artery --- vascular homeostasis

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Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.

Bacillus anthracis --- immunoassay --- single-domain antibody --- genetic fusion --- Beta galactosidase --- P-type ATPase --- nanobody --- llama --- Zinc-transport --- Zinc-transporting P-ATPase --- ZntA --- TNF --- fluorescent --- nanobodies --- sensor --- anti-cytokine therapy --- autoimmune disease --- Western equine encephalitis virus --- MagPlex --- toxin --- antibody --- camelid --- vaccine --- biodefense --- hydrogen exchange-mass spectrometry --- virus --- formatting --- Fc-domain --- half-life --- ischemia --- stroke --- MCAO --- single domain antibodies --- phage display --- intrabody --- intracellular antibody --- GTPase RHO --- BRET --- RAS --- chromobodies --- live-cell imaging --- compound screening --- cellular models --- single-domain antibody fragments --- molecular imaging --- molecular therapy --- nuclear imaging --- targeted fluorescence imaging --- intraoperative imaging --- Nanobody --- Single Domain Antibody --- Cancer --- Immunotherapy --- Imaging --- influenza --- influenza B virus --- hemagglutinin --- single domain antibody --- NanobodyTM --- yeast display --- epitope mapping --- GFP --- C. elegans --- development --- drosophila --- zebrafish --- targeted photodynamic therapy --- hepatocyte growth factor receptor --- HGFR --- c-Met --- Met --- VHH --- photosensitizer --- single-domain antibodies --- neurodegenerative diseases --- brain imaging --- blood–brain barrier --- delivery --- Aids --- HIV --- Llama Antibodies --- bi-specific VHH --- pepscan --- competition studies --- co-crystallisation --- n/a --- blood-brain barrier

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• Reference Manager
• EndNote
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Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.

Medicine --- Bacillus anthracis --- immunoassay --- single-domain antibody --- genetic fusion --- Beta galactosidase --- P-type ATPase --- nanobody --- llama --- Zinc-transport --- Zinc-transporting P-ATPase --- ZntA --- TNF --- fluorescent --- nanobodies --- sensor --- anti-cytokine therapy --- autoimmune disease --- Western equine encephalitis virus --- MagPlex --- toxin --- antibody --- camelid --- vaccine --- biodefense --- hydrogen exchange-mass spectrometry --- virus --- formatting --- Fc-domain --- half-life --- ischemia --- stroke --- MCAO --- single domain antibodies --- phage display --- intrabody --- intracellular antibody --- GTPase RHO --- BRET --- RAS --- chromobodies --- live-cell imaging --- compound screening --- cellular models --- single-domain antibody fragments --- molecular imaging --- molecular therapy --- nuclear imaging --- targeted fluorescence imaging --- intraoperative imaging --- Nanobody --- Single Domain Antibody --- Cancer --- Immunotherapy --- Imaging --- influenza --- influenza B virus --- hemagglutinin --- single domain antibody --- NanobodyTM --- yeast display --- epitope mapping --- GFP --- C. elegans --- development --- drosophila --- zebrafish --- targeted photodynamic therapy --- hepatocyte growth factor receptor --- HGFR --- c-Met --- Met --- VHH --- photosensitizer --- single-domain antibodies --- neurodegenerative diseases --- brain imaging --- blood-brain barrier --- delivery --- Aids --- HIV --- Llama Antibodies --- bi-specific VHH --- pepscan --- competition studies --- co-crystallisation