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This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation; Know how genetic and epigenetic information layers are interconnected; Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms; Understand how misregulated epigenetic mechanisms can lead to disease.
Epigenetics. --- Genetic regulation. --- Molecular genetics. --- Genetics --- Molecular biology --- Gene expression --- Gene expression regulation --- Gene regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- Regulation --- Genetics and Genomics --- Biomedicine, general --- Cell Biology --- Human Genetics --- Epigenetics --- Biomedical Research --- Medical Genetics --- Cancer --- Chromatin --- Chromatin Dynamics --- Cellular Memory --- DNA Methylation --- Epigenetic Textbook --- Gene Regulation --- Gene Silencing --- Histone Modification --- Imprinting --- Inheritance --- Metabolism --- Nucleus --- Open Access --- Pluripotency --- Reprogramming --- RNA Mechanisms --- Transcription --- X Chromosome inactivation --- Genetics (non-medical) --- Medical research --- Cellular biology (cytology) --- Epigenètica
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Understanding of the origin of species and their adaptability to new environments is one of the main questions in biology. This is fueled by the ongoing debate on species concepts and facilitated by the availability of an unprecedented large number of genomic resources. Genomes are organized into chromosomes, where significant variations in number and morphology are observed among species due to large-scale structural variants such as inversions, translocations, fusions, and fissions. This genomic reshuffling provides, in the long term, new chromosomal forms on which natural selection can act upon, contributing to the origin of biodiversity. This book contains mainly articles, reviews, and an opinion piece that explore numerous aspects of genome plasticity among taxa that will help in understanding the dynamics of genome composition, the evolutionary relationships between species and, in the long run, speciation.
Technology: general issues --- cytogenetics --- sex chromosomes --- chromosome rearrangements --- genome plasticity --- centromere --- genome biology --- evolution --- BAC-clones --- chromosome painting --- Kirk’s Dikdik --- musk ox --- saola --- nilgai bull --- gaur --- satellite DNA --- genome architecture --- chromosome restructuring --- Robertsonian translocations --- satellite DNA transcription --- comparative genomic hybridization --- karyotype variability --- repetitive DNAs --- Robertsonian translocation --- Crocidura suaveolens --- shrews --- habitat specialist --- chromosomes --- chromosomal evolution --- B-chromosomes --- chromosomal polymorphism --- mtDNA --- Rallidae --- Psophiidae --- cytogenetic --- chromosome evolution --- phylogenetic --- Anopheles --- heterochromatin --- mosquito --- mitotic chromosome --- sex chromosome --- X chromosome --- aberrant sex determination --- comparative cytogenetics --- mandarin vole --- microdissection --- high-throughput sequencing --- rearrangements --- rodents --- Ellobius alaicus --- translocation --- non-homologous chromosome connections --- meiosis --- synaptonemal complex --- sex chromosome evolution --- karyotypic and molecular evolution --- genomic architecture of sexual development --- adaptation and natural selection --- genome organization and function --- nucleolar organizing region --- dosage compensation --- faster-X and faster-Z --- climate change and global warming --- reptilian vertebrates --- comparative fish cytogenetics --- cytotaxonomy --- chromosome banding --- East Asian cypriniform fishes --- FISH --- rDNA --- snDNA --- birds --- doves and pigeons --- genome organization --- macrochromosomes --- microchromosomes --- Robertsonian fusions --- distribution --- clinal analysis --- recombination --- sexual antagonism --- chromatin state --- n/a --- Kirk's Dikdik
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Understanding of the origin of species and their adaptability to new environments is one of the main questions in biology. This is fueled by the ongoing debate on species concepts and facilitated by the availability of an unprecedented large number of genomic resources. Genomes are organized into chromosomes, where significant variations in number and morphology are observed among species due to large-scale structural variants such as inversions, translocations, fusions, and fissions. This genomic reshuffling provides, in the long term, new chromosomal forms on which natural selection can act upon, contributing to the origin of biodiversity. This book contains mainly articles, reviews, and an opinion piece that explore numerous aspects of genome plasticity among taxa that will help in understanding the dynamics of genome composition, the evolutionary relationships between species and, in the long run, speciation.
cytogenetics --- sex chromosomes --- chromosome rearrangements --- genome plasticity --- centromere --- genome biology --- evolution --- BAC-clones --- chromosome painting --- Kirk’s Dikdik --- musk ox --- saola --- nilgai bull --- gaur --- satellite DNA --- genome architecture --- chromosome restructuring --- Robertsonian translocations --- satellite DNA transcription --- comparative genomic hybridization --- karyotype variability --- repetitive DNAs --- Robertsonian translocation --- Crocidura suaveolens --- shrews --- habitat specialist --- chromosomes --- chromosomal evolution --- B-chromosomes --- chromosomal polymorphism --- mtDNA --- Rallidae --- Psophiidae --- cytogenetic --- chromosome evolution --- phylogenetic --- Anopheles --- heterochromatin --- mosquito --- mitotic chromosome --- sex chromosome --- X chromosome --- aberrant sex determination --- comparative cytogenetics --- mandarin vole --- microdissection --- high-throughput sequencing --- rearrangements --- rodents --- Ellobius alaicus --- translocation --- non-homologous chromosome connections --- meiosis --- synaptonemal complex --- sex chromosome evolution --- karyotypic and molecular evolution --- genomic architecture of sexual development --- adaptation and natural selection --- genome organization and function --- nucleolar organizing region --- dosage compensation --- faster-X and faster-Z --- climate change and global warming --- reptilian vertebrates --- comparative fish cytogenetics --- cytotaxonomy --- chromosome banding --- East Asian cypriniform fishes --- FISH --- rDNA --- snDNA --- birds --- doves and pigeons --- genome organization --- macrochromosomes --- microchromosomes --- Robertsonian fusions --- distribution --- clinal analysis --- recombination --- sexual antagonism --- chromatin state --- n/a --- Kirk's Dikdik
Choose an application
Understanding of the origin of species and their adaptability to new environments is one of the main questions in biology. This is fueled by the ongoing debate on species concepts and facilitated by the availability of an unprecedented large number of genomic resources. Genomes are organized into chromosomes, where significant variations in number and morphology are observed among species due to large-scale structural variants such as inversions, translocations, fusions, and fissions. This genomic reshuffling provides, in the long term, new chromosomal forms on which natural selection can act upon, contributing to the origin of biodiversity. This book contains mainly articles, reviews, and an opinion piece that explore numerous aspects of genome plasticity among taxa that will help in understanding the dynamics of genome composition, the evolutionary relationships between species and, in the long run, speciation.
Technology: general issues --- cytogenetics --- sex chromosomes --- chromosome rearrangements --- genome plasticity --- centromere --- genome biology --- evolution --- BAC-clones --- chromosome painting --- Kirk's Dikdik --- musk ox --- saola --- nilgai bull --- gaur --- satellite DNA --- genome architecture --- chromosome restructuring --- Robertsonian translocations --- satellite DNA transcription --- comparative genomic hybridization --- karyotype variability --- repetitive DNAs --- Robertsonian translocation --- Crocidura suaveolens --- shrews --- habitat specialist --- chromosomes --- chromosomal evolution --- B-chromosomes --- chromosomal polymorphism --- mtDNA --- Rallidae --- Psophiidae --- cytogenetic --- chromosome evolution --- phylogenetic --- Anopheles --- heterochromatin --- mosquito --- mitotic chromosome --- sex chromosome --- X chromosome --- aberrant sex determination --- comparative cytogenetics --- mandarin vole --- microdissection --- high-throughput sequencing --- rearrangements --- rodents --- Ellobius alaicus --- translocation --- non-homologous chromosome connections --- meiosis --- synaptonemal complex --- sex chromosome evolution --- karyotypic and molecular evolution --- genomic architecture of sexual development --- adaptation and natural selection --- genome organization and function --- nucleolar organizing region --- dosage compensation --- faster-X and faster-Z --- climate change and global warming --- reptilian vertebrates --- comparative fish cytogenetics --- cytotaxonomy --- chromosome banding --- East Asian cypriniform fishes --- FISH --- rDNA --- snDNA --- birds --- doves and pigeons --- genome organization --- macrochromosomes --- microchromosomes --- Robertsonian fusions --- distribution --- clinal analysis --- recombination --- sexual antagonism --- chromatin state
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