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The book covers all aspects of hysteroscopy, adenomyomas, diagnosis, management, fact and fiction, and related technological advances. It includes detailed descriptions of the history and evolution, instrumentation, and energy sources used in hysteroscopy. Further chapters cover the process of setting up hi-tech hysteroscopy units, and the maintenance and sterilization of all instruments used during surgery. The book also examines the role of hysteroscopy in infertility and recurrent pregnancy loss, uterine malformations and endometrial polyps in detail. All chapters were written by respected international experts, and are richly illustrated with colour hysteroscopic images. Given its scope, the book offers a valuable resource for all gynaecologists and graduate students.

Gynecology . --- Gynecology. --- Gynaecology --- Medicine --- Generative organs, Female --- Diseases --- Hysteroscopy. --- Uterine endoscopy --- Uteroscopy --- Endoscopy --- Uterus --- Examination

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This book provides a practical guide to the diagnosis of cervical lesions. Chapters detail recent changes to diagnostic criteria and classification and the impacts these developments have on patient management. The anatomy and histology of the cervix are discussed, along with macroscopic and microscopic changes, prognostic and predictive parameters, epidemiological data, and staging systems. Atlas of Diagnostic Pathology of the Cervix: A Case-Based Approach utilizes diagnostic algorithms and highlights to offer readers appropriate management criteria and aims to give trainees, practicing pathologists, and gynecologists a case-based approach to the treatment of cervical lesions.

Pathology. --- Gynecology . --- Surgical oncology. --- Gynecology. --- Surgical Oncology. --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Gynaecology --- Medicine --- Generative organs, Female --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Excision --- Treatment --- Cervix uteri --- Diagnosis --- Neck of the uterus --- Uterine cervix --- Uterus --- Cancer Therapy. --- Treatment. --- Cancer therapy --- Cancer treatment --- Therapy

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Hysterosalpingography. --- HSG (Gynecology) --- Hysterotubography --- Metrosalpingography --- Metrotubography --- Uterosalpingography --- Uterotubography --- Fallopian tubes --- Uterus --- Radiography --- Diagnòstic radiològic --- Esterilitat femenina --- Històries clíniques --- Casos --- Casos clínics --- Historials clínics --- Informes mèdics --- Protocols clínics --- Registres d'infermeria --- Esterilitat --- Diagnòstic per raigs X --- Diagnòstic roentgenològic --- Radiodiagnosi --- Radiodiagnòstic --- Radiologia clínica --- Radiologia per al diagnòstic --- Diagnòstic per la imatge --- Angiografia --- Gammagrafia --- Radiologia pediàtrica --- Radiologia mèdica --- Radiografia mèdica --- Raigs X

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The science of human genetics has advanced at an exponential pace since the double-helix structure of DNA was identified in 1953. Within only 25 years of that discovery, the first gene was sequenced. Subsequent efforts in the span of a few decades have brought advanced next-generation sequencing and new tools for genome editing, allowing scientists to write and rewrite the code of life. We are now realizing that genetics represents yet another system of information technology that follows Moore’s law, stating that computer processing power roughly doubles every two years. Importantly, with such rapid and sophisticated advancements, any tools or studies applicable to adult genetics can now also be applied to embryos.Genetic disorders affect 1% of live births and are responsible for 20% of pediatric hospitalizations and 20% of infant mortality. Many disorders are caused by recessive or X-linked genetic mutations carried by 85% of humans. Because assisted reproduction has armed us with technologies like in vitro fertilization that provide access to human embryos, we began to screen some genetic diseases simply by selecting sex. The first live births following preimplantation genetic testing (PGT) to identify sex in X-linked disease were reported by Alan Handyside in 1990. This groundbreaking work used the identification of male embryos and selective transfer of unaffected normal or carrier females as proof-of-concept to avoid genetic diseases, paving the way to extend the concept to PGT for monogenic diseases (PGT-M), including Mendelian single-gene defects (autosomal dominant/recessive, X-linked dominant/recessive), severe childhood lethality or early-onset disease, cancer predisposition, and HLA typing for histocompatible cord-blood stem cells’ transplantation. Later, we moved onto the identification and selection of euploid embryos by analysing all 23 pairs of chromosomes in 4–8 cells from the trophectoderm, called PGT for aneuploidy (PGT-A). PGT-A currently leverages next-generation sequencing technologies to uncover meiotic- and mitotic-origin aneuploidies affecting whole chromosomes, as well as duplications/deletions of small chromosome regions. A step forward was the use of structural chromosome rearrangements (PGT-SR) to identify Robertsonian and reciprocal translocations, inversions, and balanced vs. unbalanced rearrangements. Another advancement came with PGT for polygenic risk scoring (PGT-P). This technique takes us from learning how to read simple words to starting to understand poetry (i.e., evolving from PGT-M/A/SR to PGT-P for multifactorial, polygenic risk prediction). Moreover, we are moving from embryo selection to intervention because the genetic code is not only readable, but also re-writeable. Indeed, gene editing is now possible using tools like CRISPR/Cas9, which are applicable to all species, including human embryos.

extracellular vesicles --- exosomes --- microvesicles --- apoptotic bodies --- DNA --- preimplantation embryos --- murine blastocysts --- embryo --- uterus --- window of implantation --- PGT-A --- PGT-SR --- mosaicism --- embryo genetics --- chromosomal abnormality --- preimplantation genetic testing --- PGT-P --- polygenic risk scoring --- genomic index --- relative risk reduction --- combined preimplantation genetic testing --- Preimplantation genetic testing for monogenic disorders (PGT-M) --- Preimplantation genetic testing for aneuploidy assessment (PGT-A) --- Autosomal dominant polycystic kidney disease (ADPKD) --- male infertility --- advanced maternal age --- aneuploidy --- NGS --- segmental --- translocations --- monogenic disease --- multiplex PCR --- SNP array --- genome editing --- genetic diseases --- embryos --- vitrification --- ovarian response --- female age --- genetic testing --- reproductive health --- next-generation sequencing --- whole exome sequencing --- perinatal care --- infertility --- aneuploidies --- polygenic disease --- blastocyst --- endometrium --- implantation