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It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.

alpha-synuclein --- NMR --- secondary structure propensity --- pre-structured motifs (PreSMos) --- intrinsically disordered protein --- ubiquitin-proteasome system --- intrinsically disordered proteins --- protein misfolding --- molecular recognition features --- cancer --- neurodegenerative diseases --- protein degradation --- EPR spectroscopy --- isothermal titration calorimetry --- protein-ligand interaction --- site-directed spin labeling --- protein structural dynamics --- WASp interacting protein --- protein–protein interactions --- actin --- cytoskeleton remodeling --- SH3 domain --- proline-rich motif --- single nucleotide variants --- interface core and rim --- human disease --- intrinsically disordered regions --- linear motifs --- gene duplications --- de novo --- evolutionary origin --- circular dichroism --- flexibility --- fluorescence --- importin --- isothermal titration calorimetry (ITC) --- molecular docking --- nuclear magnetic resonance (NMR) --- nuclear protein 1 (NPR1) --- peptide --- Methyl-CpG-binding protein 2 (MeCP2) --- Rett syndrome --- intrinsically disordered protein (IDP) --- protein stability --- protein-DNA interaction --- proteostasis --- ubiquitin independent degradation --- NADH-26S proteasome --- n/a --- protein-protein interactions

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The G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Sciences (PIBOC FEB RAS) was founded in 1964 in Vladivostok in the Far East of Russia. Over many years, we have been carrying out studies on the natural products of both marine and terrestrial origin. In collaboration with many Russian and foreign scientists, we have investigated many hundreds of diverse biomolecules, including steroids and terpenoids, quinoid compounds and alkaloids, polysaccharides and lipids, enzymes and lectins, proteins, and peptides. The Institute has a collection of marine microorganisms (KMM) PIBOC, which includes more than 4000 strains of marine bacteria and more than 1000 strains of marine fungi. The biological activity of natural compounds is also being studied. This book includes the 14 manuscripts which covered almost all aspects of PIBOC research activity in the fields of bioorganic chemistry, biochemistry, organic synthesis of natural compounds, marine microbiology, and genetic engineering, and we hope it will provide interesting new information for scientists working in these fields.

Research & information: general --- polyhydroxylated steroids --- NMR spectra --- starfish --- Anthenoides laevigatus --- cytotoxicity --- soft agar assay --- kainic acid --- domoic acid --- dysiherbaine --- neodysiherbaine A --- marine bacteria --- whole genome sequence --- porin --- amino acids composition --- bilayer lipid membrane --- pore-forming activity --- spatial structure --- phlorotannins --- phlorethols --- anticancer activity --- colorectal cancer --- radiosensitizer --- radiotherapy --- 1,4-naphthoquinones --- quinoid compounds --- thioglycosides --- quinone-sugar conjugates --- cytotoxic activity --- antibiotic activity --- histochrome --- echinochrome A --- oxidative degradation --- HPLC–DAD–MS --- NMR --- actinoporin --- sea anemone --- Heteractis crispa --- anti-migratory activity --- glycosphingolipids --- cerebrosides --- peroxidation products --- structure elucidation --- allylic thioether --- ESI-MS --- GC-MS --- mass spectra --- glass sponge --- isomalabaricanes --- Stelletta sp. --- marine sponge --- terpenoid --- Cobetia amphilecti --- Cobetia litoralis --- Cobetia pacifica --- Cobetia marina --- Cobetia crustatorum --- identification markers --- alkaline phosphatase PhoA --- lanosterol 14-alpha demethylase --- flavonoids --- enzyme inhibition --- surface plasmon resonance --- spectral titration --- molecular docking --- Zobellia --- genomes --- polysaccharide lyase family 7 --- alginate utilization system --- paralogs --- orthologs --- recombinant phospholipase A1 --- Yersinia pseudotuberculosis --- inclusion bodies --- fusion protein --- green fluorescent protein --- porin gene expression --- antibiotic stress --- phenotypic heterogeneity --- n/a --- HPLC-DAD-MS

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• Reference Manager
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The G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Sciences (PIBOC FEB RAS) was founded in 1964 in Vladivostok in the Far East of Russia. Over many years, we have been carrying out studies on the natural products of both marine and terrestrial origin. In collaboration with many Russian and foreign scientists, we have investigated many hundreds of diverse biomolecules, including steroids and terpenoids, quinoid compounds and alkaloids, polysaccharides and lipids, enzymes and lectins, proteins, and peptides. The Institute has a collection of marine microorganisms (KMM) PIBOC, which includes more than 4000 strains of marine bacteria and more than 1000 strains of marine fungi. The biological activity of natural compounds is also being studied. This book includes the 14 manuscripts which covered almost all aspects of PIBOC research activity in the fields of bioorganic chemistry, biochemistry, organic synthesis of natural compounds, marine microbiology, and genetic engineering, and we hope it will provide interesting new information for scientists working in these fields.

Research & information: general --- polyhydroxylated steroids --- NMR spectra --- starfish --- Anthenoides laevigatus --- cytotoxicity --- soft agar assay --- kainic acid --- domoic acid --- dysiherbaine --- neodysiherbaine A --- marine bacteria --- whole genome sequence --- porin --- amino acids composition --- bilayer lipid membrane --- pore-forming activity --- spatial structure --- phlorotannins --- phlorethols --- anticancer activity --- colorectal cancer --- radiosensitizer --- radiotherapy --- 1,4-naphthoquinones --- quinoid compounds --- thioglycosides --- quinone-sugar conjugates --- cytotoxic activity --- antibiotic activity --- histochrome --- echinochrome A --- oxidative degradation --- HPLC-DAD-MS --- NMR --- actinoporin --- sea anemone --- Heteractis crispa --- anti-migratory activity --- glycosphingolipids --- cerebrosides --- peroxidation products --- structure elucidation --- allylic thioether --- ESI-MS --- GC-MS --- mass spectra --- glass sponge --- isomalabaricanes --- Stelletta sp. --- marine sponge --- terpenoid --- Cobetia amphilecti --- Cobetia litoralis --- Cobetia pacifica --- Cobetia marina --- Cobetia crustatorum --- identification markers --- alkaline phosphatase PhoA --- lanosterol 14-alpha demethylase --- flavonoids --- enzyme inhibition --- surface plasmon resonance --- spectral titration --- molecular docking --- Zobellia --- genomes --- polysaccharide lyase family 7 --- alginate utilization system --- paralogs --- orthologs --- recombinant phospholipase A1 --- Yersinia pseudotuberculosis --- inclusion bodies --- fusion protein --- green fluorescent protein --- porin gene expression --- antibiotic stress --- phenotypic heterogeneity